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Newer Agents • Linezolid (Zyvox) – VERY effective, but VERY expensive – Available orally – Resistance has been reported – Myelosuppression with prolonged use • Tigecycline (Tygacil) – glycylcycline – FDA approved for complicated SSTI and intraabd infxns (not pneumonia) – Active against MRSA and VRE
Newer Agents • Quinupristin-dalfopristin (Synercid) – Not approved for MRSA infections – Poor tolerability profile (arthralgias( arthralgias, myalgias, thrombophlebitis) – Need central line • Daptomycin (Cubicin) – FDA approved in 2003 for MRSA – bactericidal – Dose dependant myopathy – Not for pneumonia, CNS or bone
Page 1 and 2: Understanding and Fighting Methicil
Page 3 and 4: Understanding and Fighting Methicil
Page 5 and 6: What is MRSA Methicillin-resistant
Page 7 and 8: History of S. aureus Resistance •
Page 9 and 10: Prevalence of MRSA Colonization •
Page 11 and 12: Invasive MRSA Infection Incidence
Page 13 and 14: • CDC definitions CA vs. HA MRSA
Page 15 and 16: CA MRSA “Four Pediatric Deaths fr
Page 17 and 18: CA MRSA Outbreaks • Saint Louis R
Page 20 and 21: CA vs. HA MRSA Genetics • Communi
Page 22 and 23: CA MRSA in the hospital USA300 acco
Page 24 and 25: MRSA in the ED • MRSA the most co
Page 26 and 27: How bad can it get • Higher fatal
Page 28 and 29: MRSA Pneumonia • S. aureus is mos
Page 30 and 31: Treatment of MRSA Pneumonia • Van
Page 32 and 33: Treatment of MRSA Pneumonia • No
Page 34 and 35: Management of SSTI Infections • R
Page 36 and 37: • Clindamycin Antibiotic Options
Page 40 and 41: • Ceftobiprole Newer Agents - “
Page 42 and 43: Controlling the Spread of MRSA % Re
Page 44 and 45: HA MRSA Risk Factors • Previous a
Page 46: Questions

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