Technical Services & Facilities - Central Drug Research Institute

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Technical Services & Facilities Mastomys Rat Coucha strain Guinea Pig English albino Rabbit New Zealand White Belgian Sheep Indian breed Monkey Rhesus species Services Details -do- -do- -do- -do- a) Supply of research animals to CDRI in-house projects Total Numbers 18644 b) Supply of animals to Extramural projects in CDRI 19872 c) Supply of animals to CPCSEA registered institution Government sector Private sector Total Farm-bred Wild caught b) Supply of experimental animals for research purposes: A total of 44428 animals were supplied for research studies, out of which 5912 animals costing Rs 19,41,940/- were supplied to CPCSEA registered outside research and academic institutions including pharmaceutical companies. Break-up is given below. c) Other technical services rendered: 4187 1725 44428 • Microbiological, hematological : 937 Nos. and biochemical screening • Parasitological screening : 1016 Nos. • Nonhuman primates in rehabilitation : 26 Nos. • Tuberculin testing of monkeys performed : 222 Nos. • Chest radiography of monkeys undertaken : 60 Nos. • Pathological Monitoring including PM cases : 336 6. Tissue & Cell Culture Unit Major objective of the unit is development & upkeep of central tissue culture facility including maintenance, propagation, cryopreservation & revival of cell lines as listed in the table. During the reporting period, T-25 Cell Culture Flasks numbering 117 of various cell lines were made available to the user scientists including outside user e.g. Eastern Medikit Ltd., Gurgaon, Haryana also on payment basis. • Hep 3B Human Liver carcinoma • 3T3 L1 Mouse Embryo fibroblasts • J774 A.1 Mouse Macrophage • Vero C 1008 African Green Monkey Kidney fibroblasts • C 6 Rat Glioma • L 6 Rat Muscle • SHSY 5Y Human Neuroblastoma • hGF Human Gingival fibroblast- Primary culture • Neuro-2A Mouse Neuroblastoma 7. S&T Knowledge Resource Centre The S&T Knowledge Resource Centre (KRC) has been established with an objective to provide biomedical information services for the scientists in the era of information boom. The centre also caters to the needs of the pharmaceutical industry, entrepeneures, and researchers involved in biomedical research. The center is computerized and conforms to the norms of e- governance. KRC continued to provide information services to its users and a total of 1255 outside users (Students of M. Pharm, Biotechnology, Biomedical Sciences) utilized these services during the year. Its present collection comprises of 22494 books and 73969 bound volumes of journals. Centre also provides access to various e-journals, open source resources and bibliographic databases viz- Scifinder, Web of Science, R&D Insight etc. The centre also manages, maintains and updates the institute website and institutional repository. The centre published a monthly periodical ’Drugs & Pharmaceuticals Industry Highlights’ incorporating periodical ‘Drugs & Pharmaceutical R & D Highlights’. In addition, centre provides services to the scientists of institute and other scientific organizations in photography, power point presentations, exhibitions, display panels, posters, designing of covers and layouts for institutional publications. 8. Biometry & Statistics The division has an objective of assisting the scientists in planning and designing of experiments, analysing data and drawing inferences. During the year, laboratory data obtained from various R&D divisions were analysed within stipulated time using SYSTAT 12.0 and STATISTICA 7.0 software. The pie diagram depicts the proportional time spent for and works from various divisions during the reported period. During reporting period, a criteria has been developed for selection of glucose profiles and the probability of initial glucose levels to estimate the anti-hyperglycemic activity. Significance of percent activity was obtained for 360 compounds of a) List of cell lines under maintenance (Name of cell lines) • MCF-7 Human Breast Cancer ER +ve • MDA MB 231 Human Breast Cancer ER -ve • L 929 Mouse Connective tissue fibroblasts • THP 1 Human Monocyte • HEK 293 Human Embryo Kidney • H9c2 Rat myoblasts • Hep G2 Human Liver carcinoma 46 CSIR-CDRI
Technical Services & Facilities SLM studies, 140 compounds of STZ studies and 124 compounds of STZ-S studies. 9. Information Technology Services Computer Division provided following services during the reporting period: • Creation of Repository Database for CSIR-CDRI candidate drugs. • MoES database application software was developed and implemented for online transaction. • Setting up of a state-of-art LAN/WAN infrastructure for the New CSIR-CDRI Campus, Sitapur Road, Lucknow. • Projects leveraging NKN (National Knowledge Network) infrastructure and services. · Comprehensive ERP implementation. • Designing complete layout on internet cabling system using fiber optic and UTP cables. • Implemented antivirus software and firewall to avoid any virus threat to our Network. • Development of R&D databases and portals. • Implementation and maintenance of GLP Computers. • Complete video-conferencing and audio-visual coverage in different national and international seminars, conferences and workshops. • In-house maintenance of Online Stores & Purchase Software. • Following new software applications developed: a. Online Application for Ph.D. registration (For Academic Affairs Unit). b. SAIF Web Application (For online management of SAIF division work). c. Online Survey application for CSIR-CDRI employees. d. Online slot reservation application for UID generation (For CSIR-CDRI Staff Club). e. Online Student Management System (For Academic Affairs Unit, CSIR-CDRI). f. E-calendar for CSIR-CDRI RC-Meeting . 10. Instrumentation Instrumentation Division continued to provide efficient, economical and effective repair, maintenance, upkeep of sophisticated analytical, biomedical, electronics and laboratory equipments. Division maintained uninterrupted power supplies of all the divisions of the Institute. In case of non-availability of imported components, equivalent indigenous substitutes were installed to ensure the smooth functioning of equipments. Specifications and technical evaluations were prepared for the procurement of state of the art new equipments. Certified standards for weight, temperature, time, volume, pH and rpm were maintained. Laboratory equipments of different divisions of Institute were calibrated as per GLP guidelines. 11. Academic Affairs The unit serves as a centre for the management of research students working in different departments of the institute. The activities carried out during the period include: • Compilation of pre-Ph.D. course work under AcSIR for life and chemical sciences. • Liaised with IICB Kolkata and CLRI Chennai for the approval of AcSIR Pre-Ph.D. course work. • Liaised with Jawaharlal Nehru University for the reorientation of the Pre-Ph.D course by introducing interdisciplinary course structure, highly subjective in depth optional courses and series of specialized optional courses under life/chemical sciences for basic/applied research. • Selection of students for registration at AcSIR for Pre-Ph.D program through interview for the batches commencing fall and spring 2011 and for the spring 2012. • Liaised with AcSIR-HQ for the registration of students working at CSIR-CDRI. • Initiation of Pre-Ph.D course work under AcSIR for life sciences from Aug 2011. • Examination and evaluation of the first batch of AcSIR students. • Initiation of Pre-Ph.D course work for CSIR-CDRI students registered at Jawaharlal Nehru University. • Coordinated and conducted examination of the pre-Ph.D. course work for CSIR-CDRI students registered at Jawaharlal Nehru University. • Liaised with Jawaharlal Nehru University for timely registration, synopsis approval, thesis submission, Ph.D. viva at CSIR- CDRI etc. • Coordinated centralized admission of Junior Research Fellows for the batches commencing July 2011 and Jan 2012. • Coordinated centralized admission of GATE-JRFs for the session commencing July 2012. • Coordinated and regularized selection of LS-qualified project assistants under externally funded projects by holding interviews on 24th of every month. • Screening and endorsement of post-doctoral application forms being submitted by Ph.D. students from outside CSIR-CDRI to Indian funding agencies. • Developed a new “Human Resource Management System” software dealing with the online registration of research students (JRFs/SRFs/PAs/RAs) with the help of our Computer Division. All activities of students pertaining to leave/salary form/Ph.D. registration/ reimbursement/participation in symposium/up gradation/Thesis submission etc. will be done using this software. The software was launched 1 Jan 2012. 12. Laboratory Engineering Services The Lab Engineering Services division continued to provide Engineering Services to the Institute to maintain the Infrastructure for R&D work. The major works carried out during reporting period are as follows: • Progress monitoring & co-ordination of the New CDRI campus being setup at Sitapur Road, Lucknow. • Establishment of Animal Health Monitoring lab. • Installation of new tube well at sector ‘K’ Aliganj. • Renovation of canteen at sector ‘K’ Aliganj. • Renovation of CSIR-IITR vacated area of Animal House. • Renovation of Toilets at CSIR Dispensary, Nirala Nagar. • Roof waterproofing of CSIR Scientist Apartment Aliganj. • Air conditioning of Breeding and Experimental unit of Animal House. • Renovation of CSIR Guest House at second floor, sector ‘K’ Aliganj. • Renovation of 'Infectious block' for make shift arrangement of Accounts and Purchase division after collapse of Porch. • Maintenance of Labs, lifts, DG sets, AC plants etc. Annual Report 2011-12 47
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