Other Activities - Central Drug Research Institute

Other Activities

1MajorEvents OrganizedNational Seminar and W orkshop on MassSpectrometrySophisticated Analyti cal InstrumentFacility, CSIR-CDRI organized a National seminaron Mass Spectrometry followed by Workshopduring 11- 14 January 2011. Seventy threeparticipants from different academic institutionsand industries attended the seminar andworkshop. Invited speakers were all internationalexperts and had delivered the current state ofmass spectrometry with the highlights of hot topicsand potential future course of advances in mass spectrometry. Theworkshop provided a golden opportunity to experience the state ofthe art MS techniques and initiate lively discussion among veteranresearch scientists, academicians and budding researchers to sharetheir knowledge in the frontier areas of chemical and biologicalsciences.Diamond Jubilee International ConferenceName & Address of SpeakerTopicProf. Horst KesslerInstitute for Advanced Study, TU Munchen, Lichbergstrasse 4, 85747Garching, GermanyRational and combinatorial design ofselective integrin inhibitorsProf. David CrichCentre de Recherche de Gif, Institut de Chimie des SubstancesNaturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, FranceNew methodology for the synthesis ofpeptides, glycosides and their conjugatesGeorge FleetDepartment of Chemistry, University of Oxford, Mansifield Road,OX1 3TA, UKMonosaccharides mimics and mirrorsProf. Med. Katja BeckerChair of Nutritional BiochemistryInterdisciplinary Research Center, Justus-Liebig University Giessen,Heinrich-Buff-Riff-Ring 26-32, 35392, Giessen, GermanyRedox-based antimalarial drug discovery anupdateProf. Roger NewExecutive Director & Cofounder, Proxima Concepts Limited, London NW36ZW, UKNew frontiers in protein therapeuticsProf. Malcolm WalkinshawDirector, Institute of Structural and Molecular Biology School of BiologicalSciences, University of Edinburgh, Edinburgh.The glycolytic pathway as a target forstructure based inhibitor designDr. Satyajit RathNational Institute of Immunology, New DelhiThe calibration of cellular responses tostimulation: A case study in T- lymphocytesAnnual Report 2011-12 81

Major Events OrganizedSeminar on Purification Media by GE HealthcareLife SciencesGE Healthcare Life Sciences organized a one day seminaron Purification Media on 4 April 2011 at CSIR-CDRI. Experts from theabove organization gave lecture on following topics: Detergentscreening for optimized purification conditions for Histidine-taggedmembrane proteins & Multimodal chromatography – the “All in One”resin; Purification of GST-tagged proteins using prepacked columns;Protein phosphorylation and sample prep and simple proteinpurification and enrichment with magnetic beads. Scientists andresearch fellows from CSIR-CDRI and other Lucknow basedinstitutes participated in the deliberations.Training Program on Research Applications of FlowCytometryCSIR-CDRI and BD Biosciences (India) organized a five-daytraining program on ‘Research Applications of Flow Cytometry’ from16-20 May 2011. The program covered diverse research applicationsof flow cytometry such as multicolor immunophenotyping, cell cycleand apoptosis, cell signaling, cytokine analysis and cell sorting througha mix of didactic presentations, interactive discussion sessions andwet lab demonstrations.participated. On this occasion Prof. S. P. Dikshit, Ex- HOD, HindiDepartment, Lucknow University addressed the workshop as theChief Guest. Dr. V.N. Tiwari delivered a lecture on, “Unicode font kisahayta se computers par Hindi main Karya karne ki sambhavnayen”.Besides, Dr. Vijay Karn, Professor, Vidyant College, Lucknow andDr. S.K. Tiwari, Scientist also delivered their talks. The workshopwas concluded with the vote of thanks by Dr. V. N. Tiwari, Secretary,Nagriya Rajbhasha Karyanvayan Samiti (NRKS) Lucknow.Three Day Workshop on Scientific & TechnologicalCooperation between CSIR and TISTRFourteen research scholars attended this wet lab course.Program coordinators, Dr. Madhu Dikshit, CSIR-CDRI and Dr. PareshJain, BD biosciences provided Scientific support. Presentations/Lectures were given by Dr. Paresh Jain, Dr. Amitava Mohanty, Mr. T.Nagarjuna, Dr. Madhu Dikshit, Dr. Amit Misra. Wet lab experiment onapoptosis was performed by Mr. Anupam Jyoti and Mr. Ravi ShankarKeshari.Orientation Programme for CSIR-CDRI’s NewlyJoined StaffCSIR-CDRI, Lucknow for the first time organized Orientationprogram to its newly joined scientists, techni cal staff andadministrative personnel to familiarize them with the vision, mission,goals, ethos /culture of CSIR-CDRI and introduce them to national /global S&T and industrial scenario, IPR and contract R&D etc. Thefirst phase of the program was held during 7-29 June 2011 whichincluded visits to all the divisions of CSIR-CDRI. About 19 newlyjoined scientists and 12 technical staff participated in this orientationprogram. During their visit, all the Head of divisions gave a briefintroduction of their laboratory followed by visit to all the laboratoryand facilities in that division and interaction with bench scientists tohave hands-on experience.Hindi KaryashalaA two day workshop on Hindi Bhasha was organized atCSIR-Central Drug Research Institute, Lucknow during 27-28 June2011, in which, the members of Nagriya Rajbhasha KaryanvayanSamiti (NRKS) Lucknow and all the employees of CSIR-CDRIA three day workshop for the five member delegation fromTISTR, Thailand in the areas of Herbal drugs / medicinal plants: Lung& brain diseases, diabetes and hepatitis’ was organized during 28-30 June 2011 at CSIR-CDRI, Lucknow. The delegates were briefedwith the activities of the institute and enquired upon the happeningsat TISTR, Thailand. There were exchanges of assurances on futurecollaborative measures from both institutes. Domain experts in theabove area from CSIR-CDRI, CSIR-IITR and CSIR-CIMAP gave detailedpresentations on different topics of interest followed by visit to thelaboratories. In the concluding session, the delegation expressedtheir satisfaction over the workshop and added that they shall briefabout this workshop to the Governor, TISTR who shall, later thisyear, may invite the Director and other domain experts to visit TISTRand enable them to establish the research groups on Diabetes,Toxicology etc and can initiate the bilateral collaborative researchprograms. The Director, CSIR-CDRI handed over the mementos andcertificate of participation to all the delegates.Seminar on Biomolecular Interaction Studies UsingBiolayer Interferometry Technology & NewApplications of Microarrays in Drug DiscoveryiLife Discoveries, Manesar, Gurgaon Haryana, organized aone day seminar on Biomolecular interaction studies using biolayerAnnual Report 2011-12 85

Other ActivitiesProf. K MuniyappaRecombinational DNA repair in mycobacteria:Protein structures mechanisms and search forinhibitorsinterferometry technology & new applications of microarrays in drugdiscovery on 27 July 2011. Dr. Vipul Bhargav, Associate Director ofiLife Discoveries delivered a talk on use of Biolayer interferometrytechnology and microaarays in drug discovery. Mr. Ashwani Kamal,Application Scientist explained the technical details of abovetechniques. Scientists and Research fellows working in this domainparticipated in the programme and interacted with the experts.Live Demonstration cum Training Programme byThomson InnovationThomson Innovation is a single, integrated solution thatcombines intellectual property, scientific literature, business dataand news with analytic, collaborative and alerting tools in a robustplatform. Thomson Innovation organized a live demonstration cumtraining programme on 12 August 2011 at CSIR-CDRI. In thisprogramme, representatives demonstrated how they give us theability to research IP on our own terms. Gain optimal search powerwith Custom Fields, an exciting new capability that lets us incorporateour own data with global patent data for better, more relevantbusiness decisions.Sadbhawana Diwas“Sadbhawana Diwas” was celebrated in the institute on 19August 2011 with a theme to promote national integration andcommunal harmony among people of all religions, languages andregions. The idea behind observance of Sadbhawna Diwas is toavoid violence and to promote goodwill among the people. All theemployees of CSIR-CDRI participated in this occasion and took the“Pledge of Sadbhawana” that they will work for the emotional onenessand harmony of all the people of India regardless of caste, region,religion or language.Symposium on Proteins Shaped His Life: In Vinod’sMemoryA one day symposium entitled “Proteins Shaped His Life-inVinod’s Memory” was organized by CSIR-CDRI to pay tribute to lateDr. Vinod Bhakuni on August 24, 2011. The occasion was graced byformer Directors of the Institute and family members of Dr. VinodBhakuni. Scientists and students of the institute joined to payrespects to his memory. The symposium started with a presentationof photographs of Dr. Vinod Bhakuni and an account of his scientificcontributions. Dr. CM Gupta, former Director, CSIRCDRI talked abouthis 27-year association with Dr. Bhakuni. The scientific session hadprominent speakers from across the country as detailed below:Dr. Shekhar MandeAllosteric changes in the cAMP receptorprotein and the universality of cAMP mediatedsignalingProf. Rajiv BhatEffects of stress osmolytes on the stability,folding and aggregation of proteinsProf. P GuptasharmaA novel ‘structure-sensitive’ fluorescence frompolypeptide backbones associated withelectron transportDr. K PrakashProofreading and discard mechanisms in premRNAsplicingSix Monthly Meeting of Nagar RajbhashaKaryanvayan Samiti, LucknowThe six monthly meeting of Nagar Rajbhasha KaryanvayanSamiti (NRKS), Lucknow was organized in main auditorium of CSIR-CDRI, Lucknow on 26th August 2011. On this occasion, Dr T.K.Chakraborty, Director, CSIR-CDRI and President, Nagar RajbhashaKaryanvayan Samiti (NRKS), Lucknow chaired the meeting. Duringthe meeting, Dr. V.N. Tiwari, Senior Hindi Officer, CSIR-CDRI andSecretary NRKS presented the report of all 67 offices.Three offices were given distinguished awards and tenoffices were felicitated for working in Hindi. Three offices wereawarded for publication of Rajbhasha Patrika and other 35 officesProf. D BalasubramanianThe Greek Key Motif in crystallins and eye lenstransparency86 CSIR-CDRI

Other ActivitiesAbout 19 participants from CSIR-CDRI underwent training under thisprogram.Vigilance Awareness Week 2011In accordance with the guidelines of Central VigilanceCommission, Vigilance Awareness Week was organised during 31October to 5 November 2011. All members of the CDRI staff tookpledge to ensure transparency, identify root causes of corruptionand eradicate it from the society at all cost to the best of theirabilities. Dr. G.K. Goswami, IPS, SSP, Indian Railway, Lucknowdelivered an interesting talk on the subject. During the week, severalprograms were organized including Lecture, Debate and Essaycompetition. Winners of the events were given prizes during thevaledictory function, chaired by Dr. T.K. Chakraborty, Director, CSIR-CDRI, held on November 5, 2011.November to 1 December 2011. The experts from ILS assisted theprogramme which includes preparation of samples, labeling samples,Hybridization, Image analysis using software and data interpretations.Since the workshop was hands-on in nature, participation waslimited to only ten research fellows, from different divisions.National Conference on Challenges in DrugDiscovery and DevelopmentIndian Society of Chemists and Biologists, India organizedits National Conference on “Challenges in Drug Discovery andDevelopment (CDDD-2011) on 9-10 December 2011. Dr. P.M.S.Chauhan, General Secretary of the ISCB was organizing secretaryof this conference. Prof. Anamik Shah, president of ISCB and Dr.G.C. Saxena, president of Indian Council of Chemists and former VCAgra and Avadh University were present in inaugural function. Thetwo days scientific programs included 17 invited lectures by theeminent scientists and 4 oral presentations. 50 posters werepresented by young scientists and Ph. D. students in three differentposter sessions. Several Scientists presented their work on DrugResearch, Chemical Sciences, Bionanotechology, Chemical Biology,Glycobiology and Biochemistry. About 150 delegates from India haveparticipated this conference. The close interaction of scientists withvaried interests in diverse fields of the research is important. Thisconference has provided common platform and opportunities to theresearchers in the areas of chemical sciences and biologicalsciences and other related areas to interact with each other formutual benefits.One day symposium on Antimalarials: Currentapproaches and future directionsA one day symposium on Antimalarials: Current approachesand future directions under the aegis of OSDDm, OSDDChemOutreach and MMV was organized on 16 November 2011. Theaudience included scientists, faculty and students from CSIR-CLRI,Chennai, CSIR-NIIST, Trivandrum, IIT, Kanpur and Guwahati, IISER,Mohali, Calcutta University, CSIR-IITR, CSIR-CIMAP and CSIR-CDRI.The Director CSRI-CDRI Dr. T.K. Chakraborty initiated the meeting bywelcoming the guests from India and abroad. Dr. Chakrabortyemphasized on the role of the open science for the development ofanti-infectives and apprised the audience about the significance ofdifferent programs CSIR has initiated in the area. Dr. Jeremy Burrow,Head Discovery, MMV, Geneva was the first speaker of the day. Hegave a brief introduction about the functioning of the MMV, a virtualand “not-for-profit” foundation with the mission to discover, developand deliver antimalarial drugs. Speakers from India and abroad gavedeliberations on current approaches and future directions forantimalarials. Dr. Saman Habib, CSIR-CDRI gave a talk on proposedOSDDm program.One Day Conference on From Molecules to MedicineOne Day conference on From Molecules to Medicine washeld at CSIR-CDRI on 14 December 2011. Dr. Nitya Anand, FormerCommunal Harmony Week 2011In accordance with the guidelines of National Foundation forCommunal Harmony, the Institute celebrated Communal Harmony Weekduring 19-25 November, 2011. All staff members of the CDRI took apledge on this occasion to effectively promote the values of communalharmony and national integration amongst the people.Workshop on Gene expression studies on AffymetrixMicroarray platformA Workshop on Gene expression studies on AffymetrixMicroarray platform was organized in Toxicology Division from 2890 CSIR-CDRI

Major Events OrganizedDirector, CSIR-CDRI presided over the inauguration function. Dr. TKChakraborty, Director, CSIR-CDRI delivered welcome address.Scientific session was chaired by Prof. Manoj Kumar, VC, LucknowUniversity. Prof. CL Khetrapal gave a talk on Role of NMR in humanhealth. He discussed how NMR technique can be used to control themetabolic disorders and heart diseases. The interrelationshipbetween science and spirituality was discussed at length. Dr. NareshKumar, from Pharmalabs Pvt. Ltd. Mumbai, discussed how moleculesfind their way to market and how simple techniques are useful increating novelty in the molecules so that it becomes a block buster.Dr. Anshuman Dixit from ILS, Bhuvaneshwar discussed the role ofmolecular modeling in drug discovery and different approaches tofatten the drug development. Prof. Manoj Kumar chaired the session.Dr. Nityanad ex- director CDRI presided over the function andfelicitated Dr. AK Saxena on occasion of his 60th Birthday. Dr. BNDhawan, ex-director CDRI also shared his views on this occasion.A gathering of scientists and students from different disciplinesinteracted during conference. Dr. RP Tripathi proposed a vote ofthanks.37th Mellanby Memorial LectureIn memory of Sir Edward Mellanby, Founder Director, CSIR-CDRI, the 37th Mellanby Memorial Lecture was organized on February10, 2012. The lecture was delivered by Prof. Samir K Brahmchari,Director General of CSIR, New Delhi. The topic of his lecture was“Science 2.0: Open Source Drug Discovery in Cyber Space”. Prof.Brahmachari discussed about the web based open innovationplatform which opens up new opportunities for a systems biologyapproach to identify the Achiilles’ heel in the Mtb bug. He said, usingthis new dataset, we have built a protein interaction map of Mtbincluding more than 1400 proteins and identified the set of proteinswhich are essential in maintaining the integrity of this protein networkfor the growth and survival of Mtb. The talk explored how such anapproach can make drug discovery faster and affordable.Annual Report 2011-12 91

Other Activities2DistinguishedVisitors and LecturesName & Address Topic Date1. Dr. Pavan MuttilUniversity of New Mexico, Albuquerque2. Dr. Simi AliNewcastle University, UK3. Dr. S.C. PandeyUniversity of Illinois, USA4. Dr. Kallolmay BiswasUniversity of Edinburgh, UK5. Dr. Shantanu ChakrabortyCincinnati Children's Hospital, USA6. Prof. Peter YorkUniversity of Bradford, UK7. Dr. M.K. RaizadaUniversity of Florida, USA8. Dr. P.N. YadavUniversity of North Carolina, USA9. Dr. Ateeq AhmadJina Pharmaceuticals Inc., USA10. Dr. Rajeev S. MenonAustralian National University, Canberra11. Dr. Martine DefaisCNRS, France12. Dr. Parul TripathiICGEB, New Delhi13. Dr Amit K PandeyUniversity of MassachusettsMedical School, USA14. Dr. Ravi NatarajanKemxtree, Mumbai15. Dr. Denis MartinDNDi, Geneva16. Dr. Kumaravelu JagaveluMayo Clinic, Rochester17. Dr. Susanta KarCSIR-IICB, Kolkata18. Dr. Shreedhara GuptaHeritage Institute of Technology, Kolkata19. Dr. Kempaiah RayavaraLaboratory of Malaria andVector Research, NIH, USA20. Prof. Tejender S. ThakurIndian Institute of Science, Bangalore21. Dr. Subhabrata ChaudhuryUniversity of Glasgow, UKInhaled dry powder for chemotherapy and vaccination 04.01.2011Regulation of chemokine function during inflammation 04.01.2011Epigenetics-beyond the genome in alcoholism 19.01.2011Success in selective catalysis for organic synthesis and developmentof drugs in medicinal chemistry21.01.2011Twistl and Tbx20 function in heart development and disease 25.01.2011Particle engineering for respiratory drug delivery 31.01.2011Angiotensin converting enzyme2 as novel target for cardio-pulmonarytherapeutics08.02.2011Critical role of serotonin and its receptors in antipsychotic drug action 21.02.2011Targeting HER2, ER and endoxifen as a new cornerstone for breastcancer therapyA journey in synthesis: From perhydroazulenes to a gold mine ofheterocyclesBiological science cooperative programme between CNRS and Indiaand Europe25.03.201130.03.201108.04.2011Atherosclerosis: The immunological orchestra 25.04.2011Mycobacterium tuberculosis on steroids 19.05.2011Discovery of a new class of potent, selective and orally efficacious P38MAP Kinase inhibitors for the treatment of Rheumatoid ArthritisDNDi strategies to identify and develop new chemical entities to treatvisceral leishmaniasis23.05.201107.06.2011Protective role of MK2 in atherosclerosis 09.06.2011From cells to signalling cascades: Manipulation of macrophagedefense by leishmania parasitesA new vista towards parasitic protozoans: Leishmania andTrypanosoma14.06.201116.06.2011Functional mechanosensitive ion channel in Plasmodium falciparum 01.07.2011Computational and experimental studies on weak non.bondedinteractionsTowards the total synthesis of potent antifungal agent Gambieric AcidA: Stereo selective preparation of A.D ring fragment27.07.201109.08.201192 CSIR-CDRI

Distinguished Visitors and LecturesName & Address Topic Date22. Dr. Srinivas PentyalaStony Brook Medical Centre, New York23. Prof. Raj KumarThe Commonwealth MedicalCollege, Scranton, USA24. Dr. Yusuf AkhterEuropean Molecular BiologyLaboratory, Hamburg, Germany25. Dr. Senthil DuraisamyG7 Synergon Private Limited, Bangalore26. Dr. S. ChandrasekharCSIR-IICT, Hyderabad27. Prof. Dr. Jörg RademannLeibniz Research Institute for MolecularPharmacology, Germany28. Dr. Mallikarjun BadadaniUniversity of California Irvine, USA29. Dr. Ajit C. KunwarCSIR-IICT, HyderabadTranslational approach to drug discovery 09.08.2011Structure and functions of the steroid hormone receptors 18.08.2011Molecular and structural studies on targets from MycobacteriumtuberculosisG.Protein coupled receptor (GPCRs) and drug discovery: A historicalperspective25.08.201129.08.2011Total synthesis of marine natural products as pharmaceutical leads 19.09.2011Fragment based protein ligand discovery by dynamic ligation screening 04.11. 2011VCP (p97) functions, diseases and mouse model 2.12.2011Prof. K Rangadhama Rao Memorial Lecture (2011) entitled Peptidic.‘Foldamers’ – Structural Perspectives from NMR5.12.2011Annual Report 2011-12 93

Other Activities3InvitedLectures Delivered by Institute ScientistsDr. T.K. Chakraborty• Challenges in drug discovery – from natural products todesigner molecules, 4th International Conference on DrugDiscovery & Therapy (ICDDT), Dubai, 12-15 February 2012• Organic synthesis & drug discovery, NOST, IISER, Mohali, 15December 2011• Carbohydrates and beyond – from design to synthesis, CSIR-IICB, Kolkata, 24 November 2011• Development of novel cationic antimicrobial cyclic peptides,IIT, Madras, 29 October 2011• Organic synthesis in drug discovery (XVII Zaheer MemorialLecture), Lucknow University, Lucknow, 22 October 2011• Organic synthesis in drug discovery (Foundation Day Lecture),CSIR-NIIST, Trivandrum, 10 October 2011• Carbohydrates and beyond – from design to synthesis, INDO-RUSSIAN Meeting on Glycosciences, Zelinsky Institute,Moscow, 13-16 June 2011• Cyclooligomerization – A simple way to make complexstructures (1) IIT, Kanpur, (on the occasion of IYC), 15 April2011 (2) Guru Nanak Dev University, Amritsar, 28 March 2011(3) RTOS, Bharathidasan University, Tiruchirappalli, 23-24February 2011Dr. A.K. Saxena• Science & Healthcare, INSPIRE internship science campprogramme of DST, Integral University, Lucknow, 18 November2011• Translational research: Converting an idea to product, NewDelhi, 12 November 2011• Challenges in tuberculosis treatment, Sir MVIT Campus,Bangalore, 4 November 2011• Overview on 2D & 3D QSAR: Computational approach tostructure based ligand design, NITTTR, Bhopal, Goa extensioncentre, Goa, 19 October 2011• Docking studies and pharmacophore development, NITTTR,Bhopal, Goa extension centre, Goa, 18 October 2011• Basics and applications of QSAR and molecular modeling,Biotech Park, Lucknow, 12 October 2011• Drug designing and a case study, Biotech Park, Lucknow, 23September 2011• Hierarchical virtual screening: Identification of potentialhigh aff inity and selective 3 –Adr energic receptoragonists, Maribor, Slovenia, 7 September 2011• QSAR & molecular modeling studies in antihistamines (H1),Central University of Punjab, Bathinda, 3 May 2011• Indo- US NIAID TB drug discovery forum – Exploringopportunities for research collaboration, New Delhi, 21 April2011• Drug discovery and development: Current status, RITES,Lucknow, 23 March 2011• Let food be safe and medicated, University of Saskatchewan,Saskatoon, Canada, 14 February 2011• Computer aided drug design in drug discovery research: Acase study of carbamates as potential antialzheimer agents,University of Allahabad, Allahabad, 5 February 2011• Basics in drug design: A case study of Pyrazinopyridoindoleanalogues, University of Delhi, New Delhi, 29 December 2010Dr. S.K. Puri• Challenges and opportunities in drug discovery for malaria,CSIR-CDRI, Lucknow, 10 December 2011• Recent developments in drug di scovery for tissueschizontocidal antimalarial drugs, Anna University, Chennai,20 November 2011Dr. Ram Raghubir• Essence of pharmacovigilance practice and its future in India,Patna, India, 18-20 November 2011• Search for novel antihypertensive, BITS, Ranchi, 1 September2011• Search of bioactives from nature, NIPER, Mohali, 19 July 2011• Role of NADPH-Oxidase in cerebral ischemia reperfusion injury,M.S. University, Vadodara, 1-3 February 2011• Role of laboratory animals in drug research, IVRI, Izatnagar,27 January 2011• Current trends in drug discovery and development, College ofPharmacy, Kanpur University, Kanpur, 22 January 2011Dr. Gautam Palit• Scientific approaches in developing leads from natural productsfor peptic ulcer disease, IPS, Manipal University, Manipal, 19December 2011• BESEB as memory enhancer, CSIR-CDRI, Lucknow, 26November 2011• Pharmaco-therapeutic actions of Panax ginseng on stressand stress related neuropsychiatric disorders in rodents,Seoul, 11 November 2011• Chemistry and biology of antioxidants: Natural products basedantioxidants f rom medi cinal plants as leads towar dsdevelopment of novel drugs, Delhi University, New Delhi, 10October 2011• Scientific approaches for the development of potential drugsfor neuropsychiatric disorders, University of Pune, 14February 2011Dr. C. Nath• Role of indigenous herbal medicines in Alzheimer’s disease,CSM Medical University, Lucknow, 3 December 2011• Neuropharmacological perspectives of Alzheimer’s disease:Present & Future, Jaipur, 19 September 2011• Animal experiments for drug development, Indian NationalScience Academy (INSA), 15 September 2011• Regulatory requirements of preclinical studies prior to clinicaltrials, All India Institute of Medical Sciences (AIIMS), 26 August2011• Concepts of regulatory pr e-clinic al studi es I n dr ugdevelopment, Mahavir Cancer Sansthan, Patna, 10 June 2011• Basic elements in planning of clinical research & publication,Hind Institute of Medical Sciences, Barabanki, 06 May 2011Dr. P.K. Murthy• Research on how to get rid of an uninvited guest, IntegralUniversity, Lucknow, 18 November 201194 CSIR-CDRI

Invited Lectures Delivered by Institute ScientistsDr. Madhu Dikshit• Neutrophils derived free radicals and nitric oxide: Role in hostdegence and inflammation, Lucknow University, Lucknow, 23December 2011• Biochemical, molecular and functional status of NO/NOS inhuman mature and immature neutrophils, (1) FrankfurtUniversity, Germany, 6 December 2011 (2) Villa Vigoni, Italy,24 March 2011• Functional assays and assessment by flow cytometry, PGI,Chandigrah, 11 October 2011• Neutrophil free radical generation – involvement of iNOS, PanjabUniversity Chandigarh, 8-9 October 2011• Flow cytometry to assess cell functions and apoptosis, CSIR-CDRI, Lucknow, 19 September 2011• Biochemical and molecular characterization of iNOS in humanneutrophils and its functional importance, Sapienza UniversityDi Rome, Rome, Italy, 9 September 2011• Functi on, importance, biochemical and molecularcharacteristics nitric oxide synthase in human neutrophils,Madrid, Spain, 6 September 2011• Neutrophils, free radicals and nitric oxide in various pathologies,NII, New Delhi, 3 March 2011Dr. Anuradha Dube• Strategies for developing safe and effective vaccines againstvisceral leishmaniasis, CSIR-CIMAP, Lucknow, 14 November2011Dr. M. Abbas• Mathemati cal modeling of data in post genomic Era,Bioinformatics Centre, Biotech Park, Lucknow, 14 September2011Dr. Uma Roy• Novel streptococcus lipase: Potential Biocatalysts for Industry,Saai College of Medical Sciences & Technology, Kanpur, 7March 2011Dr. Rakesh Shukla• Mechanisms of neuroinflammation in astroglial cells and itsmodulation by melatonin, Jiwaji University, Gwalior, 30November 2011• Concepts of safety pharmacological studies, BHU, Varanasi,24 February 2011• Rodent models used for cognitive enhancer, IVRI, Bareily, 30January 2011Dr. N. Chattopadhyay• Constituents of medicinal plants positively impact bonemetabolism more than those derived from the dietary source:Evidences from in vitro, in vivo and pharmacokinetic studies,CSIR-NEIST, Jorhat, 18 Mar 2011Dr. R.P. Tripathi• Evoluti on of Gr een Chemistr y to acc ess newchemotherapeutic agents, Mizoram University, InternationalConference on Advances in Environmental Chemistry, 17November 2011• 'kdZjk tfur inkFkks± ls nok ds fodkl esa gekjk ,d iz;kl] NCLPune, 18 August 2011• Application of chemistry for human health, SRM EngineeringCollege of Technology, 3 April 2011• Chemistry driven approach towards tuberculosis, UP college,Varanasi, 12 March 2011• New chemotherapeutics agents against microbial and parasiticinfection involving efficient synthetic strategies, SLIET,Longowal, Punjab, 07 February 2011Dr. Arvind K. Srivastava• Search for potential biomolecules from ocean, AnnamalaiUniversity, Tamilnadu, 16 September 2011Dr. Neeraj Sinha• Emerging trends in testing ‘Teratology’ of pharmaceuticals,SHIATS-Deemed University, Allahabad, 25 November 2011• Safety evaluation of the ayurvedic medicine - An overview,(1) CSJM University, Kanpur, 26 March 2011 (2) State AyurvedicCollege, Lucknow, 5 March 2011Dr. P.M.S. Chauhan• Design and synthesis of Nitrogen heterocycles as noveltherapeutic agents, (1) Osmania University, Hyderabad, 28December 2011 (2) Nagpur, Maharashtra 10 February 2011• Perspectives and challenges in drug research: Design andsynthesis of Nitrogen heterocycles as novel therapeuticagents, (1) Dayalbagh Educ ational Institute,(DeemedUniversity), Agra, 6 November 2011 (2) Annamalai University,14 October 2011 (3) Rajkot, 7 February 2011• Design and synthesis of Nitrogen heterocycles as antiparasiticagents, Saurashtra University, Rajkot, 29 September 2011Dr. P.K. Shukla• Monoclonal antibodies in diagnosis and therapy of fungalinfections, Jawaharlal Nehru Centre for Advanced ScientificResearch, Bangalore, 1 August 2011• Emerging scenario for diagnosis and treatment of fungalinfection, CSMM University, Lucknow, 11 February 2011Dr. R. K. Singh• Drug induced haematotoxicity and its amelioration by plantproducts, Seminar on Pharmacist: A Health Care Professional,Rameshwaram Institute of Technology and Management,Lucknow, 26 November 2011• Animal models for leukemia and its prevention by plant products,Mahavir Cancer Sansthan, Patna, 10 June 2011Dr. Brijesh Kumar• Chemical profiling of Berberis aristata, Berberis asiatica andCos sini um f enes trat um using high resolution MassSpectrometry instruments for quality control, Kottayam, 12September 2011• Chemical profiling of Piper betle, Tinospora cordifolia andMahonia borealis using High Resolution Mass Spectrometryinstruments for quality assurance, CSIR-NBRI, Lucknow, 17December 2011Dr. Neena Goyal• Identification of inhibitors of leishmanial Dipeptidylcarboxypeptidase:A novel target for drug discovery, Cancun, Mexico,14 December 2011Dr. Saman Habib• Open Source Drug Discovery for Malaria, OSDD-MMVsymposium on ‘Anti-malarials: current approaches and newdirections, CSIR-CDRI, Lucknow, 16 November 2011• Factors involved in translation initiation and ribosomal recyclingin Plasmodium organelles, ISS, Rome, 6 October 2011• Metabolic functions of the Plasmodium apicoplast, CSIR-CDRIDiamond Jubilee International Symposium, 10 February 2011Dr. S.K. Rath• Cancer: The genetic association, Training school for BiologyTeachers, S.C.B. PG College, Hardoi, UP, 15 November 2011Annual Report 2011-12 95

Other Activities• Cell culture research: The understanding of cancer, AMITYUniversity, Lucknow, 3 April 2011• Genotoxicity evaluation; Past, present and future, BharatidasanUniversity, Tiruchi, 3 February 2011Dr. Amit Mishra• Inhalable particles for value- added dr ug delivery inTuberculosis, Mumbai, 14 November 2011• Nano and “dunno” in drug and antigen delivery, NIPER,Chandigarh, 1 March 2011• Biodegradable nanoparticles in the murine vagina: Transcervicalretrograde transport and induction of proinflammatorycytokines, IITR, Lucknow, 2 February 2011Dr. Sanjay Batra• Cascade strategies for the syntheses of aza-heterocycles,GNDU Amritsar, 23 December 2011• Drug discovery efforts for anti-infectives: Paradigm shifttowards Open Source Model, CSIR-CECRI, Karaikudi,20 December 2011• Transition metals-assisted strategies for the synthesis ofdiverse annulated pyrazoles, NCL, Pune, 9 December 2011• Probing allylamines for heterocyclic synthesis, AllahabadUniversity, Allahabad, 5 December 2011• Antimalarials: CDRI’s perspective and Chemistry Outreach,Antimalarials: Current Approaches and Future Directions, CDRI,Lucknow, 16 November 2011• Engineering new routes to heterocycles via Morita-Baylis-Hillman chemistry, Indian Institute of Science, Bangalore, 4November 2011• A Medicinal Chemist’s perspective, IIT-M, Chennai, 28 October2011• Template-directed synthesis of diverse annulated-â-carbolines,Jammu University, Jammu, 23 September 2011• Allylamines: A versatile source for Aza-heterocycles, Schoolof Chemistry, University of Hyderabad, Hyderabad, 19 August2011• Template-directed synthesis of diverse annulated betacarbolines,DST school on Green Chemistry, IIT, Guwahati, 8March 2011• Allylamines from Morita-Baylis-Hillman chemistry: A versatilesource to aza-heterocycles, DST school on Green Chemistry,IIT, Guwahati, 7 March 2011• Repositioning of drugs, NII, New Delhi, 11 February 2011Dr. Kumkum Srivastava• In-vitro culture of human malaria parasite, Plasmodiumfalciparum - A journey to recent developments, AmityUniversity, Lucknow, 4 March 2011Dr. Ashish Arora• Determining the solution structure of peptides and proteinsusing NMR spectroscopy, IMTECH, Chandigarh, 20 October2011• Structural characterization of drug target proteins using NMRspectroscopy, Biotech Park, Lucknow, 13 October, 2011• NMR studies of drug target proteins at CSIR-CDRI, IIT, Kanpur,15 April 2011Dr. Atul Goel• Molecular diversity-oriented synthesis of aromatic scaffoldsand their light emitting properties, Lucknow University,Lucknow, 15 October 2011Dr. Gautam Panda• Synthesis of natural products and natural product-likemolecules in drug discovery research, Institute for MolecularScience, Okazaki, Japan, 29 September 2011Dr. Jimut Kanti Ghosh• Sy nthetic peptides to understand structur e-functi onrelationships in naturally occurring antimicrobial peptides anda voltage gated ion channel, S. Banerjee College, Hooghly,West Bengal, 18 November 2011.Dr. K.R. Arya• Chemical profiling of Indian medicinal plants using highresolution Mass Spectrometry instruments f or qualityassurance, CSIR-NBRI, Lucknow, 17 December 2011• Validation and rapid characterization of an ethnobotanical leadfor osteogenic activity isolated from traditional plant used forhealing fractured bone in Uttarakhand Himalaya, Institute ofHolistic Medical Sciences (IHMS), Kottayam, 12 September2011Dr. T. Narender• Development of dual acting agents (antihyperglycemic andantidyslipidemic) from the Indian medicinal plants, (1)Gurunanak College of Pharmacy, Nagpur, 24 November 2011(2) Institute for Holistic Medical Sciences (IHMS), Kottayam,11 September 2011Dr. S. Sanyal• Bile acid receptor agonist GW4064 regulates PPARãcoactivator-1á expression through estrogen receptor-relatedreceptor, Indira Gandhi Pratisthan, Lucknow, 14 November2011Dr. R.S. Ampapathi• Structural studies of NTD of STAT4 protein, IICT, Hyderabad,23 March 2011Dr. Ritu Trivedi• Cell Culture Techniques for bioactivity evaluation, NDRI, Karnal,10 March 2011.Dr. Akhilesh K. Tamrakar• Natural molecules with GLUT4 translocation stimulatory effectfor the treatment of insulin resistance, Institute for HolisticMedical Sciences, Kottayam, 13 September 2011.Dr. Arun Trivedi• Functional inactivation of C/EBPalpha in myeloid leukemia, Pune,16 October 2011• Proteomic approaches in myeloid leukemia, New Delhi, 5 April2011Dr. Rajender Singh• Genomics in functional bowel diseases, SGPGI, Lucknow, 5August 2011Dr. Sanjeev Kumar Shukla• Polysilanes as UV/NUV Light Emitters, D.S. (P.G.) College,Kanpur, 23 January 2011Dr. J.R. Gayen• Role of Chromogranin-A in hypertension and diabetes, KarunyaUniversity, Coimbatore, 9 December 2011Mr. Harish Gauniyal• NMR and its applications, chemistry of biologically activecompounds, CIMAP, Lucknow 28 January 201196 CSIR-CDRI

4Visits AbroadName of the Scientist Country Purpose of Visit (Period of Deputation)Dr. T.K. ChakrabortyRussia To deliver an invited lecture at INDO-RUSSIAN Meeting (13-16 June 2011)Dubai To deliver an invited lecture at International conference (12-15 February 2012)Dr. A.K. SaxenaCanada To participate in a workshop (13-15 February 2011)Slovenia &GermanyTo attend the International symposium (03-16 September 2011)Dr. Gautam Palit South Korea To deliver an invited lecture in international conference (9-11 November 2011)Dr. Madhu DikshitItaly To attend a conference and project meeting (23-26 March 2011)Spain Meeting with Prof. Santiago Lamas (31 August– 14 September 2011)Italy To deliver a lecture (9 September 2011)Austria To participate as a speaker in EU-India Science & Technology Cooperation Days 2011(01-02 December 2011)Germany To attend project meeting (03-07 December 2011)Dr. Rakesh Shukla Scotland Under INSA-RSE International exchange program (24 August- 23 September 2011)Dr. Sudhir Kumar SinhaDr. D.S. UpadhyaySwitzerlandTheNetherlandsTo participate in the Indo-Swiss symposium (04-06 May 2011)For advance research work (01-30 October 2011)To attend International training course (04-15 July 2011)Dr. Neena Goyal Mexico To attend an International conference (11-15 December 2011)Dr. Neeloo Singh USA International fellowship for senior biomedical scientist (14-28 February 2011)Mr. Pradeep KumarShrivastavaBrazil To attend international symposium and workshop (17-24 October 2011)Dr. Shard Sharma Israel To attend OECD GLP training course for GLP inspectors (31 October – 02 November,2011)Dr. Saman HabibUK To attend a meeting (14 March 2011)Italy To attend the meeting (06-07 October 2011)Dr. Atul Goel Germany To complete remaining research work under Alexander von Humboldt Fellowship (02May - 30 July 2011)Dr. J. Venkatesh Pratap France To carry out an experiment at the European Synchrotron Radiation Facility (09-12 July2011)Dr. Manoj Barthwal USA To carry out the advance research (15 November 2010 - 14 November 2011)Dr. Ritu Trivedi Australia To attend the meeting (04-08 September 2011)Dr. Aamir Nazir Australia To attend the conference (10-13 July 2011)Annual Report 2011-12 97

Other Activities5Membershipof Scientific Societies and CommitteesDr. Tushar K. Chakraborty• Member, American Chemical Society, USA• Life Member, (1) Chemical Research Society of India, (2)Indian Chemical Society, (3) Indian Peptide Society• Member, (1) Senior Science Committee, OSDD; (2) ChemicalSciences Sectional Committee, Indian Academy of Sciences;(3) Sectional Committee III in Chemical Sciences, The IndianNational Science Academy (4) Program Advisory Committee(Organic Chemistry), DST; (5) Steering Committee, NationalBio-resource Development Board, DBT; (6) Sub-committee ofSponsored Schemes Research Committee, CSIR; (7) ExpertCommittee, Drugs and Pharmaceuticals Research Programme,DST; (8) Drugs Technical Advisory Board, Ministry of Health &Family Welfare (9) Technical Advisory Committee, TechnologyDevelopment and Utilization Programme for Women, DSIR; (10)High Powered Committee, NMITLI Projects, CSIR• Member Editorial Board, (1) Indian Journal of Chemistry, B;(2) Indian Journal of Biochemistry & Biophysics; (3) The NaturalProducts JournalDr. A.K. Saxena• Member, American Chemical Society, USA• Member, (1) Expert Committee, Ministry of Chemicals &Fertilizers, Department of Pharmaceuticals (India) (2) INDCommittee, Directorate General of Health Services, Office ofDrugs Controller General (India), (3) REACH INDIA TASKFORCE, Department of Chemical and Petrochemicals, Govt. ofIndia (4) Board of International Charitable Foundations’(Scientific Partnership) Coordinating Board, Russia, (5) Boardof Directors, American Bibliography Inc. USA• UGC Nominee, Advisory Committee, Special AssistanceProgramme, (1) Department of Chemistry, SaurashtraUniversity, Rajkot, (2) Department of Chemistry, A. P. SUniversity, Rewa• Secretary, QSAR Society of India• Life Member, (1) Indian Chemical Society, (2) IndianAssociation of Medicinal ChemistsDr. S.K. Puri• Vice President, Indian Society for Parasitology• Member, Scientific Advisory Committee, Vector ControlResearch Centre, PondicherryDr. G. Palit• Member, International Advisory committee of InternationalCongress of EthnopharmacologyDr. C. Nath• Life Member, (1) International Brain Research Organization;(2) National Academy of Medical Sciences; (3) IndianPharmac ological Soc iety ; (4) Indian Academy ofNeurosciences; (5) Society of Toxicology, India• Member, (1) Advisory Committee for IND Permission, DrugController General of India, Ministry of Health, Government ofIndia; (2) Research Council, IITR; (3) Academic committee,JNU, New Delhi• Member: Editorial Board, Toxicology InternationalDr. Ashim Ghatak• Member, (1) American College of Clinical Pharmacology; (2)National Academy of Medical Sciences (MNAMS)• Fellow of Indian College of Physicians-FICPDr. A.K. Dwivedi• Life Member, Indian Pharmaceutical Association• Member, Drugs Panel for New Drugs Manufactur ingLicenses, Directorate of Medical & Health Services, UttarPradesh• Joint Secretary, Indian Society of Chemists and Biologists,LucknowDr. Madhu Dikshit• President, Cytometry Society of India• Member, (1) Steering Committee, MoES Project, New Delhi;(2) Organic & Medicinal Chemistry and Chemical TechnologyResearch Committee, CSIR, New DelhiDr. Anuradha Dube• Member, Editorial Board, (1) J ournal of BiomedicalResearch; (2) BioMed Central, Infectious Diseases (OpenAccess)Dr. J.K. Saxena• Secretary, Indian Society for Parasitology• Vice President, Society of Biologists and Chemists• Member, Editorial Board, Asian Pacific Journal of TropicalMedicine• Life Member, Indian Society for Parasitology; (2) Society ofBiological Chemists (India); (3) Indian Immunological Society;(4) International Society of Applied Biology; (5) Indian NationalScience Congress Association; (6) Indian Society of Chemistsand Biologists• Fellow, Zoological Society of IndiaDr. Naibedya Chattopadhyay• Member, Editor ial Boar d, (1) American J our nal ofPhysiology (Endocrinology Metabolism), (2) BiochemicalPharmacology, (3) World Journal of PharmacologyDr. Neeraj Sinha• Life Member, (1) National Academy of Sciences, Allahabad,(2) Indian Society of Cell Biology, New Delhi, (3) Society ofToxicologists of India, Izatnagar, (4) Indian Science CongressAssociation, Kolkata, (5) Association of Biotechnology andPharmacy, India.Dr. D.S. Upadhyay• Member, (1) CPCSEA sub-committee for rehabilitation oflaboratory animals, (2) Live Stock Feed, Equipments andSystem, Sectional Committee, FAD 5, Bureau of IndianStandards, New Delhi, (3) Veterinary Council of India; (4) U.PVeterinary Council, Lucknow• CSIR Nominee, National Institute of Animal Welfare, MoEF,Govt. of IndiaDr. P.M.S. Chauhan• General Secretary, Indian Society of Chemists and Biologists• Executive Member and Sectional President, IndianCouncil of Chemists (30 th ICC, Hyderabad)• Editor- in- Chief, Chemistry & Biology Interface• Member, Editorial board (1) Future Medicinal Chemistry,98 CSIR-CDRI

Membership of Scientific Societies and Committees(2) Journal Research and Reports in Medicinal Chemistry; (3)Mycobacterial Diseases (4) Global Journal of OrganicChemistryDr. Anila Dwivedi• Life Member, (1) Society of Reproductive Biology andComparative Endocrinology, India; Indian Society for Study ofReproduction and Fertility; Endocrine Society of IndiaDr. V.L. Sharma• Life member, (1) Chemical Research Society of India,BangaloreDr. Renu Tripathi• Life Member, Zoological Society of India, Bodh Gaya• Member, Organizing Committee, 22 nd All India Congress ofZoology 2011Dr. D.N. Upadhyay• Life Member, Society for Advancement of ElectrochemicalScience & TechnologyDr. M.N. Srivastava• Member, Board of panel for PSC on R&D of Central SectorScheme for Conservation Development and SustainableManagement of Medicinal plants, National Medicinal PlantsBoard, (AYUSH), Ministry of Health & Family Welfare,Government of IndiaDr. A.K. Srivastava• Life Member, Indian Society of ParasitologyDr. Neena Goyal• Member, Execut ive Committee, Indi an Society f orParasitologyDr. Saman Habib• Member, (1) Expert Advi sory Group, CRI MALDDI(Coordination, Rationalization and Integration of AntimalarialDrug Discovery Initiatives) project of the European Union; (2)Indian Society for Cell BiologyDr. Gopal GuptaLife member, Indian Society for Study of Reproduction and FertilityDr. Jawahar Lal• Advisor, Current Trends in Pharmaceutical Research• Member, Editorial Advisory Board, Chemistry & BiologyInterfaceDr. Srikanta Kumar Rath• Joint Secretary-Elected, Indian Society for Cell Biology(2011-13);• Life member, (1) Indian Society of Cell Biology; (2) Societyof Toxicology, India; (3) Environmental Mutagen Society ofIndia; (4) Genome Foundation, India• Member, Editorial Board, Toxicology InternationalDr. Amit Misra• Life Member, Indian Pharmaceutical AssociationDr. Sanjay Batra• Member, (1) Council of NOST, India (2011-2014); (2)Governing Council, Chemical Research Society of India,BangaloreDr. Ashish Arora• Member, NMRS, IndiaMr. Prem Prakash• Life member, Indian Pharmaceutical AssociationDr. Atul Goel• Life member, (1) Chemical Research Society of India,Bangalore; (2) Indian Chemical SocietyDr. R.K. Tripathi• Life Member, (1) Society of Toxicology, India; (2) IndianSociety of Cell BiologyDr. K.R. Arya• Member, (1) Executive Council, Society of Ethnobotanists;(2) Board of panel for DPC in Directorate of Census (U.P.),Govt of IndiaDr. P.R. Mishra• Member, Editorial Board, (1) Recent Patents in DrugDelivery and Formulations, (2) Journal of Pharmaceutical andBiomedical Sciences• Founder Member, Indian Nanoscience Society• Life Member, Indian Pharmaceutical AssociationDr. Manish K. Chourasia• Life Member, Indian Pharmacy Graduate AssociationDr. Dhananjoy Hansda• Member, Indian Association of Veterinary Microbiologists,Immunologists & Specialists in Infectious Diseases• Member, West Bengal Veterinary CouncilDr. Akhilesh Tamrakar• Member, Society of Biological Chemist, IndiaDr. Prem Prakash Yadav• Life member, Chemical Research Society of India, BangaloreDr. Kalyan Mitra• Life Member, Electron Microscopy Society of India (EMSI)Dr. Aamir Nazir• Life Member, Indian Society of Cell BiologyDr. Poonam Singh• Life Member, Society of Toxicology, India• Member, Editorial/Advisory Board, International Journal ofComprehensive PharmacyMr. Ranveer Singh• Life member, Indian Institute of Chemical EngineerMr. Wahajuddin• Member, Editorial Board, (1) Journal of Bioequivalence &Bioavailability; (2) Analytica Pharmaceutica Acta; (3)Pharmaceutical Regulatory Affairs• Life Member, (1) Indian Society for Mass Spectrometry; (2)Indian Pharmacological Society; (3) Indian Science CongressAssociation; (4) Laboratory Animal Science Association ofIndia; (5) Biotechnology Research Society of India; (6) IndianSociety of Analyti cal Scientists; (7) Association ofBiotechnology and Pharmacy; (8) Society of BiologicalChemists, India; (9) IDMA- Association of PharmaceuticalAnalysts (APA)Dr. Sripathi Rao Kulkarni• Life Member, (1) Association of Microbiologists of India; (2)Society for Information Science, IndiaDr. J.R. Gayen• Life Member, (1) The Society of Biological Chemists (India),Bangalore, India; (2) Association of Biotechnology andPharmacy (ABAP), India; (3) Indian Society for MassSpectrometry (ISMAS), Mumbai, India• Fellow of Association of Biotechnology and Pharmacy, GunturDr. Sanjeev Yadav• Life Member, (1) Indian Science Congress Association,Kolkata; (2) Society for Science & Environment, IndiaAnnual Report 2011-12 99

Other ActivitiesNotes100 CSIR-CDRI