Anil Gaikwad - Central Drug Research Institute

Name:Designation:Department:Dr. Anil N. GaikwadScientistDrug Target Discovery and Development DivisionPhone (off.): 0522‐2612411 Ext 4410Phone (mob.): 9415795140Email:anil_gaikwad@cdri.res.inAcademic BackgroundMasters : NIPER, Mohali‐160062 , 2000Doctorata: CSIR‐CDRI – JNU, 2007Professional ExperienceSr. Molecular Biologist, Zydus Research Centre, Ahmedabad (2000‐2001)Junior Scientist, Central Drug Research Institute, Lucknow (2003‐2006)BOYSCAST Fellow, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden Germany(2008‐09)Scientist, Central Drug Research Institute, Lucknow (2006‐ onwards)Research InterestFor initial years at CDRI I was working in the field of Tubeculosis. After my post‐doc, I have initiatedwork in the field of Insulin resistance.Adipocyte biology: Adipocyte is considered major endocrine organ and play important role in wholebody energy homeostasis. Our laboratory is involved identification of new molecules perturbingadipocyte differentiation process and in depth studies of mechanism of adipogenesis inhibition ofthese molecules. These molecules will be of importance for therapeutic interventions of obesity.Systems biology of adipocyte insulin resistance: Fully differentiated adipocytes show insulinresistance upon exposure to inflammatory cytokines, chronic insulin treatment, high superoxide andsteroids. Laboratory is currently working on understanding mechanistic pathways responsible forthese changes using various approaches like phospho‐proteomics, microarray, antibody array, Si‐

RNA mediated gene silencing and high content imaging. The long term goal is to evolve systemsunderstanding of out of these studies.PublicationsGaikwad AN and Sinha S - Determinants of natural immunity against tuberculosis in anendemic setting: factors operating at the level of macrophage-Mycobacterium tuberculosisinteraction (2008) - Clin Exp Immunol 151, 414-22Ghosh S, Tiwari P, Pandey S, Misra AK, Chaturvedi V, Gaikwad A, Bhatnagar S and SinhaS - Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamidederivatives (2008) - Bioorganic and Medicinal Chemistry Letters 18, 4002-5Singh BK, Yadav AK, Kumar B, Gaikwad AN, Sinha SK, Chaturvedi V and Tripathi RP -Preparation and reactions of sugar azides with alkynes: synthesis of sugar triazoles asantitubercular agents (2008) - Carbohydrate Research 343, 1153-1162Das Sajal Kumar, Panda Gautam, Chaturvedi Vinita, Manju YK, Gaikwad Anil K and SinhaSudhir. - Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives.(2007) - Bioorganic & Medicinal Chemistry Letters 17, 5586-5589Panda Gautam, Parai Maloy Kumar, Das Sajal Kumar, Shagufta, Sinha Manish, ChaturvediVinita, Srivastava Anil K, Manju YK, Gaikwad Anil N and Sinha Sudhir. - Effect ofsubstituents on diarylmethanes for antitubercular activity. (2007) - European Journal ofMedicinal Chemistry42, 410-419Saquib M, Gupta MK, Sagar R, Prabhakar YS, Shaw AK, Kumar R, Maulik PR, Gaikwad AN,Sinha S, Srivastava AK, Chaturvedi V, Srivastava R and Srivastava BS - C-3 alkyl/arylalkyl-2,3-dideoxy hex-2-enopyranosides as antitubercular agents: Synthesis, biological evaluation,and QSAR study.(2007) - Journal of Medicinal Chemistry 50, 2942-2950Tripathi, R P; Saxena, Nisha; Tiwari, V K; Verma, S S; Chaturvedi, Vinita; Manju, Y K;Srivastva, A K;Gaikwad, A; Sinha, S - Synthesis and antitubercular activity of substitutedphenylmethyl- and pyridylmethyl amines (2006) - Bioorganic & Medicinal Chemistry,Volume 14, Issue 24, 8186-8196Tripathi, R.P., Verma, S.S., Pandey, Jyoti, Agarwal, K.C., Chaturvedi, Vinita, Manju, Y.K.,Srivastva, A.K., Gaikwad, A. and Sinha, S. - Search of antitubercular activities intetrahydroacridines: Synthesis and biological evaluation (2006) - Bioorganic & MedicinalChemistry Letters, Volume 16, Issue 19 , 5144-5147Katiyar, D. , Tiwari, V.K., Tewari, N. , Verma, S.S. , Sinha, S. , Gaikwad, A. , Srivastava, A. ,Chaturvedi, V. , Srivastava, R. , Srivastava, B.S. & Tripathi, R.P. - Synthesis andantimycobacterial activities of glycosylated amino alcohols and amines, (2005) - EuropeanJournal of Medicinal Chemistry, Volume 40, Issue 4, 351-360.Panda, Gautam, Mishra, Jitendra Kumar, Sinha, Sudhir, Gaikwad, Anil K, Srivastava, Anil K,Srivastava, Ranjana & Srivastava, Brahm S. - 4-{10-(methoxybenzyl)-9-anthryl}phenolderivatives as new antitubercular agents. (2005) - Arkivoc, 29-45.

Sinha S., Kosalai K., Arora S., Namane A., Sharma P., Gaikwad A.N., Brodin P., Cole S.T. -Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed byproteomics(2005) - Microbiology, 151, 2411-2419Srivastava, T & Gaikwad, Anil K, Haq, Wahajul, Sinha, Sudhir & Katti, S.B. - Synthesis andbiological evaluation of 4-thiazolidinone derivatives as potential antimicrobial agents. (2005) -Arkivoc, 120-30.Tripathi, R.P. , Tiwari, V.K. , Tewari, N. , Katiyar, D. , Saxena, N. , Sinha, S. , Gaikwad, A.,Srivastava, A. , Chaturvedi, V. , Manju, Y.K. et al. - Synthesis and antitubercular activities ofbis-glycosylated diamino alcohols, (2005) - Bioorganic & Medicinal Chemistry, 13, 5668-79Tewari, N., Tiwari, V.K., Tripathi, R.P., Chaturvedi, V., Srivastava, A., Srivastava, R., Shukla,P.K., Chaturvedi, A.K., Gaikwad, A., Sinha, S. & Srivastava, B.S. - Synthesis ofgalactopyranosyl amino alcohols as a new class of antitubercular and antifungalagents. (2004) - Bioorganic and Medicinal Chemistry Letters, Volume 14, Issue 2, 2004,Pages 329-332.R. Pathak, C. S. Pant, A. K. Shaw, A. P. Bhaduri, A. N. Gaikwad, S. Sinha, A. Srivastava, K.K. Srivastava, V. Chaturvedi, R. Srivastava and B. S. Srivastava, "Baylis-Hillman Reaction:Convenient Ascending Syntheses and Biological Evaluation of Acyclic DeoxyMonosaccharides as Potential Antimycobacterial Agents", Bioorganic & MedicinalChemistry 10 :10, 2002, 3187-3196