The Discovery of GSK2251052: A First-in-Class Boron ... - Anacor
The Discovery of GSK2251052: A First-in-Class Boron ... - Anacor
The Discovery of GSK2251052: A First-in-Class Boron ... - Anacor
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43<br />
<strong>GSK2251052</strong> Phase 1 Results Showed L<strong>in</strong>ear PK<br />
with Blood Levels Reach<strong>in</strong>g <strong>in</strong> Excess <strong>of</strong> MIC90 Levels<br />
IV Dose<br />
Mean AUC*<br />
(h.µg/ml)<br />
Mean Cmax*<br />
(µg/ml)<br />
MAD 1 500 mg BID x 8 days 56 9.4<br />
MAD 2 750 mg BID x 14 days 76 11.5<br />
MAD 3 1200 mg BID x 14 days 117 19.1<br />
MAD 4 2000 mg BID x 14 days 193 31<br />
*Mean PK parameter for last day <strong>of</strong> dos<strong>in</strong>g
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