Combined Analog/digital signaling in local cortical networks

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These Results Indicate That the Amplitude of the EPSP Encodes the Membrane Potential of the Presynaptic Cell. This Indicates that Information is NOT Encoded Only Through the Pattern of Action Potentials. Rather, Information is Encoded as a Mixture of Spike Pattern and Membrane Potential of the Presynaptic Cell and Network
Critical Points to be determined: 1) Mechanism (change in basal or triggered presynaptic Ca2+, change in axonal action potential duration, or voltage-dependent changes in synaptic transmission) 2) Kinetics (evidence for slow and fast components) 3) Voltage Dependence (appears to be linear in the range of rest to firing threshold) Goal: Understand the Functional (Computational) Consequences of Mixed Transmission on Cortical and Brain Function
Page 1 and 2: Lab Members Combined Analog/digital
Page 3 and 4: Membrane Potential of Cortical Neur
Page 5 and 6: Subthreshold synaptic potentials tr
Page 7 and 8: Models of Complete Axonal Tree Indi
Page 9 and 10: Morphology of the Two Pyramidal Cel
Page 11: Action-potential free Synaptic Tran
Page 15 and 16: Depolarization-induced facilitation
Page 17 and 18: Possible Mechanism 1: Changes in AP
Page 19 and 20: Possible Mechanism 2: Changes in pr
Page 21 and 22: Small Voltage Steps at the Calyx of
Page 23 and 24: Group data illustrating the depende
Page 25: Conclusions: Local Information Tran

Combined Analog/digital signaling in local cortical networks

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