Combined Analog/digital signaling in local cortical networks
Combined Analog/digital signaling in local cortical networks
Combined Analog/digital signaling in local cortical networks
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Conclusions:<br />
Local Information Transmission <strong>in</strong> the Cerebral Cortex (and other bra<strong>in</strong> areas) may occur<br />
through a mix of “graded” and “triggered” or analog and <strong>digital</strong> modes.<br />
The mechanisms of this mixed communication may <strong>in</strong>volve:<br />
Variations <strong>in</strong> axonal action potential duration<br />
Variations <strong>in</strong> presynaptic Ca2+ levels<br />
Voltage dependent changes <strong>in</strong> release probability<br />
The use of a comb<strong>in</strong>ed “analog/<strong>digital</strong>” mode of synaptic transmission may <strong>in</strong>crease<br />
the efficiency of <strong>in</strong>formation cod<strong>in</strong>g <strong>in</strong> the bra<strong>in</strong> and may be important <strong>in</strong> the<br />
operation of neuronal assemblies. The mechanisms and implications rema<strong>in</strong> to be<br />
determ<strong>in</strong>ed.
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