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Cancer Pain Management: An Overview - Palliative.info

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CONVERTING OPIOIDS<br />

NB: Does not consider incomplete cross-tolerance<br />

Drug<br />

Hydromorphone<br />

Oxycodone<br />

Codeine<br />

Approximate Equipotency with<br />

Morphine<br />

(Morphine:Drug)<br />

5:1<br />

1.5:1 to 2:1<br />

1:12<br />

Daily Morphine Dose<br />

Methadone<br />

30 – 90 mg<br />

90 – 300 mg<br />

> 300 mg<br />

Fentanyl<br />

3.7:1<br />

7.75:1<br />

12.75:1<br />

80:1 to 100:1 (for subcutaneous dosing of<br />

each)<br />

19

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