Staphylococcus aureus

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Unique S. <strong>aureus</strong> lineages Kennedy, Adam D. et al. (2008) Proc. Natl. Acad. Sci. USA 105, 1327-1332 Success Why USA300 Clonal expansion-”correct” combination of virulence factors time Selection against
How does the Clinical Microbiology Laboratory detect MRSA from nasal swabs b • Mannitol salt agar with cefoxitin – Least sensitive and most time consuming • Chromogenic agar‐Detects specific enzymes within S. <strong>aureus</strong> (β‐glucosidase or a phosphatase) plus chromogenic cephamycin. – Low sensitivity (~75%), high specificity at 24 hours – increased sensitivity at 48 hours JCM 2008: 46:1577-1587
Page 1 and 2: Staphylococcus aureus • Significa
Page 3 and 4: Goals • What are the differences
Page 6 and 7: S. aureus lineages (e.g. clonal bac
Page 8: 1999 MMWR • Four Pediatric deaths
Page 11 and 12: Superantigen Production CA-MRSA n=3
Page 13 and 14: Prevalence of CA‐MRSA ~2003‐pre
Page 15 and 16: • USA 300 MRSA most prominent S.
Page 17 and 18: Panton Valentine Leukocidin • Dat
Page 19: Enhanced or found in USA300 Common
Page 23: Conclusions • S. aureus USA300 is

Staphylococcus aureus

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