Staphylococcus aureus

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Molecular Assays • Due to increased MRSA screening in hospitals, Microbiology laboratories need to invest in methodologies that decrease turn around time. • PCR‐based assays (same day results) – Demonstrated to decrease MRSA transmission incidence (J. Hosp. Infect. 2007. 65:24‐28) – IDI‐MRSA/GeneOhm MRSA – GeneXpert MRSA assay • Both yield increased sensitivity (~85 to 100%) • GeneXpert allows for single sample testing without bthi batching.
Conclusions • S. <strong>aureus</strong> USA300 is an epidemic in the United States. • Contains a repertoire of virulence factors that allow it to effectively colonize and cause wide variety of disease manifestations. • Due to increased screening of patients to detect MRSA colonization, i microbiology laboratories need to develop expertise in PCR technologies.
Page 1 and 2: Staphylococcus aureus • Significa
Page 3 and 4: Goals • What are the differences
Page 6 and 7: S. aureus lineages (e.g. clonal bac
Page 8: 1999 MMWR • Four Pediatric deaths
Page 11 and 12: Superantigen Production CA-MRSA n=3
Page 13 and 14: Prevalence of CA‐MRSA ~2003‐pre
Page 15 and 16: • USA 300 MRSA most prominent S.
Page 17 and 18: Panton Valentine Leukocidin • Dat
Page 19 and 20: Enhanced or found in USA300 Common
Page 21: How does the Clinical Microbiology

Staphylococcus aureus

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