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Management of Extravasation of Cytotoxic Drugs in Children

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Document Title<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong><br />

<strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Type <strong>of</strong> document<br />

Corporate: Cl<strong>in</strong>ical<br />

Brief summary <strong>of</strong> contents<br />

Executive Director responsible for<br />

Policy:<br />

Directorate / Department responsible<br />

(author/owner):<br />

Guidance on the management <strong>of</strong><br />

extravasation <strong>in</strong> children<br />

Director <strong>of</strong> Nurs<strong>in</strong>g, Midwifery and AHPs<br />

Sabr<strong>in</strong>a Tierney / Pharmacy<br />

Contact details: 01872 252590<br />

Date written: October 2011<br />

Date revised:<br />

This document replaces (exact title <strong>of</strong><br />

previous version):<br />

Approval route (names <strong>of</strong><br />

committees)/consultation:<br />

Divisional Manager confirm<strong>in</strong>g<br />

approval processes<br />

Name and Post Title <strong>of</strong> additional<br />

signatories<br />

Equality Impact Assessment appended<br />

Approval must not be given if the EIS<br />

is not attached<br />

Signature <strong>of</strong> Executive Director giv<strong>in</strong>g<br />

approval<br />

Publication Location (refer to Policy<br />

on Policies – Approvals and<br />

Ratification):<br />

Document Library Folder/Sub Folder<br />

N/A<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong><br />

<strong>Drugs</strong><br />

Child Health Directorate Guidel<strong>in</strong>es<br />

Committee<br />

Medic<strong>in</strong>es Practice Committee<br />

Peter Trethewy, Director <strong>of</strong> Diagnostics<br />

and Therapeutics<br />

N/A<br />

Yes<br />

{Orig<strong>in</strong>al Copy Signed}<br />

Internet & Intranet Intranet Only<br />

Cl<strong>in</strong>ical, RCHT, Chemotherapy<br />

Date <strong>of</strong> f<strong>in</strong>al approval: 1 st February 2012<br />

Date policy becomes live: 1 st February 2012<br />

Date due for revision: 1 st December 2015<br />

L<strong>in</strong>ks to key external standards


Related Documents: See Appendix 6<br />

Suggested Keywords:<br />

Tra<strong>in</strong><strong>in</strong>g Need Identified<br />

<strong>Extravasation</strong>, Chemotherapy<br />

Yes - All nurses tra<strong>in</strong>ed <strong>in</strong> <strong>in</strong>itial<br />

chemotherapy tra<strong>in</strong><strong>in</strong>g, and to attend<br />

oncology update day annually<br />

This document is only valid on the day <strong>of</strong> pr<strong>in</strong>t<strong>in</strong>g<br />

Controlled Document<br />

This document has been created follow<strong>in</strong>g the Royal Cornwall Hospitals NHS Trust<br />

Policy on Document Production. It should not be altered <strong>in</strong> any way without the<br />

express permission <strong>of</strong> the author or their L<strong>in</strong>e Manager.<br />

Policy Template


<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong><br />

<strong>Children</strong><br />

V1.0<br />

October 2011<br />

Policy Template<br />

Page 3 <strong>of</strong> 22


Version Control Table<br />

Date<br />

Version<br />

No<br />

Summary <strong>of</strong> Changes<br />

F<strong>in</strong>al amendments approved; EIA<br />

20.12.07 V1.0 Completed; document published<br />

Changes Made by<br />

(Name and Job Title)<br />

Jo Blogs<br />

Manager<br />

All or part <strong>of</strong> this document can be released under the Freedom <strong>of</strong> Information Act<br />

2000<br />

This document is to be reta<strong>in</strong>ed for 10 years from the date <strong>of</strong> expiry.<br />

Policy Template<br />

Page 4 <strong>of</strong> 22


Table <strong>of</strong> Contents<br />

1. Purpose and Scope ..................................................................................6<br />

2. Def<strong>in</strong>ition...................................................................................................6<br />

3. Ownership and Responsibilities................................................................7<br />

4. Monitor<strong>in</strong>g <strong>of</strong> the patient ...........................................................................7<br />

5. Patient Education......................................................................................7<br />

6. Signs and Symptoms................................................................................8<br />

7. Treatment <strong>of</strong> Peripheral L<strong>in</strong>e <strong>Extravasation</strong>..............................................9<br />

8. Treatment <strong>of</strong> <strong>Extravasation</strong> from Central Venous Access Devices:<br />

PICC’s, Hickman L<strong>in</strong>es & Portacaths.............................................................12<br />

9. Mixed <strong>Extravasation</strong>s..............................................................................13<br />

10. Documentation ....................................................................................13<br />

11. Monitor<strong>in</strong>g compliance and effectiveness ...........................................14<br />

12. Updat<strong>in</strong>g and Review ..........................................................................14<br />

13. Equality and Diversity..........................................................................14<br />

Appendix 1: <strong>Drugs</strong> commonly used <strong>in</strong> Paediatric oncology and their<br />

classification ..................................................................................................15<br />

Appendix 2: Non- <strong>Cytotoxic</strong> <strong>Extravasation</strong>....................................................16<br />

Appendix 3 : <strong>Extravasation</strong> Kit Contents.......................................................17<br />

Appendix 4 : Guidel<strong>in</strong>es for Best Practice When Adm<strong>in</strong>ister<strong>in</strong>g Intravenous<br />

Infusions ........................................................................................................18<br />

Appendix 5: Patient Information Sheet...........................................................19<br />

Appendix 6 - References ...............................................................................20<br />

Appendix 7.Initial Equality Impact Assessment Screen<strong>in</strong>g Form ...................21<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 5


1. Purpose and Scope<br />

1.1 This document outl<strong>in</strong>es guidel<strong>in</strong>es for the rapid treatment <strong>of</strong> extravasation <strong>in</strong>juries<br />

<strong>in</strong> paediatric patients with<strong>in</strong> Royal Cornwall Hospital Trust, exclud<strong>in</strong>g neonates,<br />

for which there is a separate policy.<br />

1.2 It provides a guidel<strong>in</strong>e to assist practitioners <strong>in</strong> the care <strong>of</strong> patients who may have<br />

experienced an extravasation <strong>in</strong>jury.<br />

1.3 It will provide a basis for the nurs<strong>in</strong>g staff to recognise ways <strong>in</strong> which to help<br />

prevent extravasation and how to recognise when an extravasation has occurred.<br />

2. Def<strong>in</strong>ition<br />

2.1 <strong>Extravasation</strong> is the leakage or accidental <strong>in</strong>filtration <strong>of</strong> <strong>in</strong>travenous drugs <strong>in</strong>to the<br />

surround<strong>in</strong>g tissues from the ve<strong>in</strong>. This can lead to an immediate <strong>in</strong>flammatory<br />

pa<strong>in</strong>ful reaction and with some drugs may result <strong>in</strong> local tissue destruction<br />

(necrosis) and other complications.<br />

<br />

<br />

<br />

<br />

Neutrals do not cause ulceration and are unlikely to produce an acute<br />

reaction or progress to necrosis.<br />

Irritants are capable <strong>of</strong> caus<strong>in</strong>g <strong>in</strong>flammation and irritation. They rarely<br />

proceed to the breakdown <strong>of</strong> tissues. They do have the potential to cause<br />

ulceration, but only if a large amount has extravasated <strong>in</strong>to the tissue.<br />

Exfoliants are capable <strong>of</strong> caus<strong>in</strong>g <strong>in</strong>flammation and shedd<strong>in</strong>g <strong>of</strong> the sk<strong>in</strong>, but<br />

are less likely to cause tissue death. They can cause pa<strong>in</strong><br />

Vesicants are drugs that have the potential to cause blister<strong>in</strong>g and ulceration,<br />

which when left untreated can lead to tissue damage and necrosis.<br />

2.2 It is recognised that prevention <strong>of</strong> extravasation is <strong>of</strong> importance and particularly<br />

when adm<strong>in</strong>ister<strong>in</strong>g vesicants or irritants the precautions should be taken to<br />

m<strong>in</strong>imise the risk <strong>of</strong> extravasation, see appendix 4.<br />

2.3 It is accepted that there are also other contribut<strong>in</strong>g factors that can affect each<br />

<strong>in</strong>dividual patient’s risk <strong>of</strong> extravasation.<br />

2.4 There are many different drugs that can equally be as destructive <strong>in</strong> the damage<br />

that they can cause if extravasation occurs, the ma<strong>in</strong> bulk <strong>of</strong> this document<br />

relates to cytotoxic chemotherapy, but the procedure outl<strong>in</strong>ed can be used for all<br />

vesicant drugs. Please note that there is a separate guidel<strong>in</strong>e for the<br />

extravasation <strong>of</strong> non-cytotoxic drugs <strong>in</strong> the neonate.<br />

2.5 Cancer drugs have been grouped <strong>in</strong>to 5 categories based on their potential to<br />

cause tissue damage, see appendix 1.<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 6


3. Ownership and Responsibilities<br />

3.1 The Trust Lead for Cancer Chemotherapy is responsible for ensur<strong>in</strong>g the<br />

implementation and adherence to these guidel<strong>in</strong>es. The Specialist<br />

Cl<strong>in</strong>ical Pharmacists <strong>in</strong> Paediatrics will aid the Cancer Lead <strong>in</strong> this role.<br />

3.2 The ward manager <strong>of</strong> Sennen ward is responsible for the education and<br />

development <strong>of</strong> nurs<strong>in</strong>g staff <strong>in</strong> the handl<strong>in</strong>g, adm<strong>in</strong>istration and disposal<br />

<strong>of</strong> cytotoxic drugs.<br />

3.3 It is the <strong>in</strong>dividual practitioner’s responsibility to ensure the tra<strong>in</strong><strong>in</strong>g they<br />

have received is appropriate, and rema<strong>in</strong>s updated.<br />

3.4 Ward requirements:<br />

3.4.1. Each cl<strong>in</strong>ical area where vesicant cytotoxic drugs are adm<strong>in</strong>istered<br />

must have a Paediatric <strong>Extravasation</strong> Kit available (i.e. Sennen ward and<br />

Gwithian Unit)<br />

3.4.2. Monthly checks <strong>of</strong> the <strong>Extravasation</strong> kit are the responsibility nurse<br />

<strong>in</strong> charge. This requires a check <strong>of</strong> the contents and the expiry date, and<br />

these checks should be recorded <strong>in</strong> the record book provided for this<br />

prupose.<br />

3.4.3. Replacement paediatric extravasation kits are available from<br />

pharmacy<br />

4. Monitor<strong>in</strong>g <strong>of</strong> the patient<br />

4.1 Dur<strong>in</strong>g adm<strong>in</strong>istration <strong>of</strong> <strong>in</strong>travenous medication the <strong>in</strong>jection site should be<br />

clearly visible and monitored for redness and swell<strong>in</strong>g regularly (see Appendix 4:<br />

“Guidel<strong>in</strong>es for best practice” for more detailed <strong>in</strong>formation on monitor<strong>in</strong>g<br />

requirements).<br />

5. Patient Education<br />

5.1 Patients/parents/guardians should be educated to the fact that extravasation is a<br />

potential risk <strong>of</strong> receiv<strong>in</strong>g chemotherapy when consent is obta<strong>in</strong>ed.<br />

5.2 Patient preference to cannulation site (if required) should be taken <strong>in</strong>to account,<br />

but education given as to why good placement and rotation <strong>of</strong> site is required.<br />

5.3 Education should encourage patients to <strong>in</strong>form nurs<strong>in</strong>g staff if they have pa<strong>in</strong>,<br />

st<strong>in</strong>g<strong>in</strong>g, burn<strong>in</strong>g or a change <strong>in</strong> sensation at cannulation site from start <strong>of</strong> the<br />

<strong>in</strong>fusion.<br />

5.4 In the advent <strong>of</strong> an extravasation patients should be provided with both verbal<br />

and written <strong>in</strong>formation, see appendix 5<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 7


6. Signs and Symptoms<br />

An extravasation should be suspected if one or more <strong>of</strong> the follow<strong>in</strong>g symptoms have<br />

occurred:<br />

6.1 The patient compla<strong>in</strong>s <strong>of</strong> burn<strong>in</strong>g, st<strong>in</strong>g<strong>in</strong>g, pa<strong>in</strong> or any discomfort at the <strong>in</strong>jection<br />

site. This should be dist<strong>in</strong>guished from a feel<strong>in</strong>g <strong>of</strong> cold that may occur with some<br />

drugs. The patient is <strong>of</strong>ten the first person to become aware that someth<strong>in</strong>g is<br />

wrong with the IV therapy, so <strong>in</strong>struct them at the beg<strong>in</strong>n<strong>in</strong>g <strong>of</strong> treatment to <strong>in</strong>form<br />

staff <strong>of</strong> any acute change dur<strong>in</strong>g treatment.<br />

6.2 Observation <strong>of</strong> swell<strong>in</strong>g, redness, mottl<strong>in</strong>g or blister<strong>in</strong>g at the <strong>in</strong>jection site. This<br />

should be dist<strong>in</strong>guished from the ‘nettle rash’ or ‘flare’ effect seen with some<br />

drugs.<br />

6.3 Care should be tak<strong>in</strong>g when no ‘flash back’ or blood return is obta<strong>in</strong>ed on<br />

aspiration. However, this is not a sign <strong>of</strong> extravasation if found <strong>in</strong> isolation and the<br />

presence <strong>of</strong> blood does not exclude extravasation<br />

6.4 There is <strong>in</strong>creased resistance felt on the plunger <strong>of</strong> the syr<strong>in</strong>ge <strong>of</strong> a bolus drug<br />

adm<strong>in</strong>istration, this however, could be due to possible changes <strong>in</strong> the position <strong>of</strong><br />

the body.<br />

6.5 There is absence <strong>of</strong> free flow or the rate <strong>of</strong> flow is remarkably reduced. This may<br />

not be recognisable when us<strong>in</strong>g an <strong>in</strong>fusion pump.<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 8


7. Treatment <strong>of</strong> Peripheral L<strong>in</strong>e <strong>Extravasation</strong><br />

Action<br />

1 Stop the adm<strong>in</strong>istration <strong>of</strong> the cytotoxic drug<br />

immediately, leav<strong>in</strong>g the cannula <strong>in</strong> place.<br />

Rationale<br />

To prevent further <strong>in</strong>filtration and to allow aspiration <strong>of</strong><br />

the drug to be attempted (see below)<br />

2 Expla<strong>in</strong> what has been suspected <strong>of</strong><br />

happen<strong>in</strong>g and next procedure to the<br />

patient/parent/guardian.<br />

To obta<strong>in</strong> patient’s and/or carer’s co-operation and<br />

consent.<br />

3 Disconnect any IV tub<strong>in</strong>g from the<br />

<strong>in</strong>travenous cannula, do not remove the<br />

cannula. Attempt to aspirate as much drug<br />

as possible with a new syr<strong>in</strong>ge.<br />

To prevent further <strong>in</strong>fusion through the l<strong>in</strong>e.<br />

To remove any residual drug.<br />

4 Contact a senior member <strong>of</strong> nurs<strong>in</strong>g and<br />

<strong>in</strong>form medical staff.<br />

Obta<strong>in</strong> the experience <strong>of</strong> other colleagues<br />

Obta<strong>in</strong> Paediatric <strong>Extravasation</strong> Kit<br />

5 Mark the area with a pen and take digital<br />

pictures if possible (after patient consent)<br />

To enable the size <strong>of</strong> the area to be evaluated and<br />

recalled at first presentation.<br />

7 Remove the cannula<br />

Adm<strong>in</strong>ister pa<strong>in</strong> relief as required<br />

8 Use flow sheet below and/or table<br />

(Appendix 1) to identify agent and<br />

determ<strong>in</strong>e action to be taken<br />

Ensure patient comfort<br />

To identify specific relevant <strong>in</strong>structions<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 9


Peripheral extravasation identified<br />

Stop <strong>in</strong>fusion, Leave cannula <strong>in</strong> place, Aspirate as much <strong>of</strong> the drug as possible us<strong>in</strong>g a new 10mL syr<strong>in</strong>ge, contact senior<br />

member <strong>of</strong> staff/medical staff, Mark area with pen, Remove cannula, Treat as follows:<br />

Group 1 <strong>Drugs</strong><br />

Non-vesicants/neutrals<br />

Asparag<strong>in</strong>ase, Bleomyc<strong>in</strong>, Cladrib<strong>in</strong>e,<br />

Cyclophosphamide, Cytarab<strong>in</strong>e, Fludarab<strong>in</strong>e,<br />

Ifosfamide, Melphalan, Rituximab<br />

If large volume seek advice from St. Chad’s<br />

If possible recannulate<br />

<strong>in</strong> opposite<br />

arm and recommence<br />

chemotherapy<br />

Group 2 & 3 <strong>Drugs</strong><br />

Inflammitants & Irritants<br />

Carboplat<strong>in</strong>, Cisplat<strong>in</strong>,<br />

Etoposide, Etoposide<br />

Phosphate, Ir<strong>in</strong>otecan,<br />

Methotrexate, Topotecan<br />

Draw up 100mg hydrocortisone and<br />

adm<strong>in</strong>ister S/C <strong>in</strong> a clockwise direction<br />

around circumference <strong>of</strong> the extravasation<br />

site followed by a th<strong>in</strong> layer <strong>of</strong> topical<br />

hydrocortisone 1% cream<br />

Use the relevant heat/cold pack to apply warm/cold compression<br />

Apply heat/ cold pack for one hour post <strong>in</strong>cident and then for 20 m<strong>in</strong> four times a day<br />

for 48hrs.<br />

Group 4 & 5<br />

Exfoliants and<br />

Vesicants<br />

Amsacr<strong>in</strong>e,<br />

Carmust<strong>in</strong>e<br />

Dact<strong>in</strong>omyc<strong>in</strong><br />

Daunorubic<strong>in</strong>*<br />

Doxorubic<strong>in</strong>*,<br />

Epirubic<strong>in</strong>,<br />

Idarubic<strong>in</strong><br />

Mitomyc<strong>in</strong><br />

Mitoxantrone<br />

Apply topical DMSO every 2<br />

hours at the extravasation<br />

site (DO NOT apply to<br />

healthy sk<strong>in</strong>) followed by<br />

topical hydrocortisone 1%<br />

cream. See also note below.<br />

* for Liposomal preparation<br />

delay DMSO for 8–12 hours<br />

Group 5<br />

V<strong>in</strong>ca<br />

Alkaloids<br />

V<strong>in</strong>blast<strong>in</strong>e,<br />

V<strong>in</strong>crist<strong>in</strong>e,<br />

V<strong>in</strong>des<strong>in</strong>e,<br />

V<strong>in</strong>orelb<strong>in</strong>e<br />

Dissolve 1500 units<br />

Hyaluronidase <strong>in</strong> 1mL water for<br />

<strong>in</strong>jection. Adm<strong>in</strong>ister<br />

Hyaluronidase 0.1-0.2mL S/C <strong>in</strong> a<br />

clockwise direction around<br />

circumference <strong>of</strong> the<br />

extravasation site. Gently<br />

massage area to facilitate<br />

dispersal <strong>of</strong> drug.<br />

Elevate limb for up to 48 hrs. Give prescribed analgesia & PO chlorphenam<strong>in</strong>e prn for<br />

comfort. If any concerns contact St. Chads, Birm<strong>in</strong>gham for advice (0121 5543801)<br />

Complete necessary documentation (medical notes, DATIX and green card). Ensure<br />

patient has appropriate follow up arrangements.<br />

<strong>Drugs</strong> requir<strong>in</strong>g heat pack <strong>in</strong> red, those for<br />

cold pack <strong>in</strong> blue<br />

Apply heat pack for 1 hour<br />

post & then for 20m<strong>in</strong> every<br />

4hrs for 48hrs. Apply a th<strong>in</strong><br />

layer <strong>of</strong> Hydrocortisone 1%<br />

cream and cover with 2<br />

squares <strong>of</strong> gauze and<br />

bandage <strong>in</strong>to position<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 10


DMSO (Dimethyl Sulphoxide):<br />

DMSO is stored <strong>in</strong> the chemotherapy cupboard on Sennen ward. When used or<br />

go<strong>in</strong>g out <strong>of</strong> date, please ensure the ward pharmacist is made aware so replacement<br />

supplies can be arranged.<br />

DMSO is an unlicensed medication, and as such records <strong>of</strong> its use need to be kept.<br />

When us<strong>in</strong>g DMSO please ensure that the record form is completed and returned to<br />

the ward pharmacist.<br />

DMSO should be prescribed by the medical team before giv<strong>in</strong>g, and is for<br />

EXTERNAL use only<br />

Gloves must be worn when apply<strong>in</strong>g DMSO – it may harm healthy sk<strong>in</strong>.<br />

After the first 24 hours treatment, for the next 7-14 days apply a th<strong>in</strong> layer <strong>of</strong> DSMO<br />

every 6 hours us<strong>in</strong>g a cotton bud, alternat<strong>in</strong>g with topical hydrocortisone cream every<br />

6 hours (a preparation applied every 3 hours on an alternate basis), check<strong>in</strong>g the<br />

area for erythema regularly. If blister<strong>in</strong>g occurs, stop treatment with DMSO and<br />

seek advice from St. Chad’s<br />

For liposomal preparations at 8-12 hours post <strong>in</strong>cidence apply DSMO 2-hourly for the<br />

next 24 hours, and then 4 times a day for a further 10-14 days.<br />

Do not use an occlusive cover. If required cover once the area is dry.<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 11


8. Treatment <strong>of</strong> <strong>Extravasation</strong> from Central Venous<br />

Access Devices: PICC’s, Hickman L<strong>in</strong>es & Portacaths<br />

8.1 Although less likely to occur an extravasation occurr<strong>in</strong>g from an <strong>in</strong>dwell<strong>in</strong>g<br />

central l<strong>in</strong>e can be particularly problematic because <strong>of</strong> the depth <strong>of</strong> the l<strong>in</strong>e and<br />

the potential <strong>of</strong> slower development <strong>of</strong> signs and symptoms.<br />

8.2 <strong>Extravasation</strong> can either occur <strong>in</strong> the tunnelled section or <strong>in</strong> the deep section <strong>of</strong><br />

the implanted l<strong>in</strong>e:<br />

8.3 <strong>Extravasation</strong> can occur due to fracture <strong>of</strong> the catheter, perforation <strong>of</strong> the<br />

superior vena cava, formation <strong>of</strong> a fibr<strong>in</strong> sheath on catheter or <strong>in</strong>complete<br />

placement or dislodgement <strong>of</strong> the needle.<br />

8.4 Patients should be educated to the possibility <strong>of</strong> this happen<strong>in</strong>g and that burn<strong>in</strong>g<br />

or pa<strong>in</strong> on adm<strong>in</strong>istration is not normal and should be reported immediately.<br />

8.5 Follow steps as above, leav<strong>in</strong>g the central l<strong>in</strong>e <strong>in</strong> place. The l<strong>in</strong>e should be x-ray<br />

and removed as soon as cl<strong>in</strong>ically appropriate.<br />

8.6 Referral to plastic surgeon should be made<br />

Immediate Action<br />

1 Stop the adm<strong>in</strong>istration <strong>of</strong> the cytotoxic drug<br />

immediately, leav<strong>in</strong>g the central l<strong>in</strong>e <strong>in</strong> place.<br />

Rationale<br />

To prevent further <strong>in</strong>filtration.<br />

Prompt action to m<strong>in</strong>imise damage is important.<br />

2 Expla<strong>in</strong> what has been suspected <strong>of</strong> happen<strong>in</strong>g<br />

and next procedure to the<br />

patient/parent/guardian.<br />

To obta<strong>in</strong> patient’s and/or carer’s co-operation and<br />

consent.<br />

3 Attempt to aspirate as much drug as possible<br />

with a new syr<strong>in</strong>ge.<br />

To remove any residual drug.<br />

4 Mark the area with a pen and take digital pictures<br />

if possible<br />

To enable the size <strong>of</strong> the area to be evaluated and<br />

recalled at first presentation.<br />

5 Immediately refer to a senior member <strong>of</strong> medical<br />

staff<br />

The potential for damage is much greater than with<br />

a peripheral l<strong>in</strong>e.<br />

6 Refer to plastic surgeon For specialist <strong>in</strong>put<br />

7 Complete all documentation. Green Card<br />

(available <strong>in</strong> the extravasation kit), DATIX,<br />

medical and nurs<strong>in</strong>g notes<br />

Record all actions taken (see below)<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 12


9. Mixed <strong>Extravasation</strong>s<br />

In the event <strong>of</strong> an extravasation where different agents may have been given the<br />

follow<strong>in</strong>g applies.<br />

9.1 The order <strong>of</strong> priority is vesicant, exfoliant, irritant.<br />

9.2 For drugs <strong>of</strong> different classifications apply the temperature compress <strong>of</strong> the drug<br />

that takes priority.<br />

9.3 For drugs <strong>of</strong> the same classification a cold compress takes priority over a hot<br />

compress.<br />

10. Documentation<br />

Each <strong>in</strong>cident <strong>of</strong> extravasation must be carefully recorded, with an accurate account<br />

<strong>of</strong> the event and signed by the report<strong>in</strong>g nurse.<br />

10.1 Demographic:<br />

<br />

<br />

<br />

<br />

<br />

Patient demographic details (name, address, and hospital number).<br />

Date and time <strong>of</strong> <strong>in</strong>cident.<br />

Cl<strong>in</strong>ical area<br />

Chemotherapy protocol and drug sequence.<br />

Patient’s symptoms and appearance <strong>of</strong> site.<br />

10.2 Description <strong>of</strong> IV access<br />

<br />

<br />

<br />

<br />

Needle size and type<br />

Insertion site and number <strong>of</strong> attempts,<br />

Flash back present.<br />

Drug adm<strong>in</strong>istration technique i.e. ‘bolus or <strong>in</strong>fusion’.<br />

10.3 <strong>Extravasation</strong> area<br />

<br />

<br />

<br />

<br />

Approximate amount <strong>of</strong> drug extravasated.<br />

Appearance <strong>of</strong> area<br />

Diameter, length and width <strong>of</strong> area effected<br />

Photograph, if taken.<br />

10.4 Step by step <strong>of</strong> action taken<br />

<br />

<br />

<br />

<br />

<br />

<br />

<br />

Amount aspirated<br />

Cold/hot applied<br />

Antidote given<br />

Nurs<strong>in</strong>g team and medical person notified.<br />

Patient’s comments, compla<strong>in</strong>ts and statements.<br />

Referrals made<br />

Patient <strong>in</strong>formation sheet given and follow up arranged<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 13


10.5 National Database<br />

• A national database <strong>of</strong> extravasation <strong>in</strong>cidents is be<strong>in</strong>g compiled by<br />

Andrew Stanley, St. Chad’s unit, Dudley road, Birm<strong>in</strong>gham. Report<strong>in</strong>g<br />

cards should be sent follow<strong>in</strong>g any extravasation and are available<br />

<strong>in</strong>side the extravasation kit. www.extravasation.org.uk<br />

11. Monitor<strong>in</strong>g compliance and effectiveness<br />

All <strong>Extravasation</strong>s will be recorded and DATIX as pre policy. An audit <strong>of</strong> these will<br />

be completed once a year and presented at the Paediatric Chemotherapy Multi<br />

Discipl<strong>in</strong>ary team meet<strong>in</strong>gs, by the author (overseen by the Trust Lead for<br />

Cancer Chemotherapy).<br />

Element to be<br />

monitored<br />

Lead<br />

Tool<br />

Frequency<br />

Report<strong>in</strong>g<br />

arrangements<br />

Act<strong>in</strong>g on<br />

recommendations<br />

and Lead(s)<br />

Change <strong>in</strong><br />

practice and<br />

lessons to be<br />

shared<br />

All chemotherapy extravasations with the child health<br />

directorate<br />

Sabr<strong>in</strong>a Tierney, Specialist Cl<strong>in</strong>ical Pharmacist<br />

(paediatrics)<br />

Audit observ<strong>in</strong>g type <strong>of</strong> drug that extravasated, cannula<br />

position, length <strong>of</strong> time cannula <strong>in</strong>, antidote<br />

Audit completed yearly<br />

Presented to Paediatric Multi-Displ<strong>in</strong>ary Team<br />

Paediatric Chemotherapy MDT lead – Nicki Gilbertson,<br />

Paediatric Consultant<br />

<strong>Extravasation</strong>s education to be provided and staff to be kept<br />

up to date with new developments <strong>in</strong> this area.<br />

All nurs<strong>in</strong>g staff to ma<strong>in</strong>ta<strong>in</strong> tra<strong>in</strong><strong>in</strong>g, <strong>in</strong>clud<strong>in</strong>g annual update<br />

day.<br />

12. Updat<strong>in</strong>g and Review<br />

12.1. This policy will be reviewed every 3 years by the Paediatric Guidel<strong>in</strong>es<br />

Committee<br />

13. Equality and Diversity<br />

13.1. This document complies with the Royal Cornwall Hospitals NHS Trust<br />

service Equality and Diversity statement.<br />

13.2. The Initial Equality Impact Assessment Screen<strong>in</strong>g Form is at Appendix 1.<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 14


Appendix 1: <strong>Drugs</strong> commonly used <strong>in</strong> Paediatric oncology<br />

and their classification<br />

(Taken from www.extravasation.org.uk)<br />

Chemotherapy agent<br />

Amsacr<strong>in</strong>e<br />

Asparag<strong>in</strong>ase<br />

Bleomyc<strong>in</strong><br />

Campath (Alemtuzumab)<br />

Carboplat<strong>in</strong><br />

Carmust<strong>in</strong>e<br />

Cisplat<strong>in</strong><br />

Cladrib<strong>in</strong>e<br />

Cyclophosphamide<br />

Cytarab<strong>in</strong>e<br />

Dact<strong>in</strong>omyc<strong>in</strong>/act<strong>in</strong>omyc<strong>in</strong> D<br />

Daunorubic<strong>in</strong><br />

Doxorubic<strong>in</strong><br />

Epirubic<strong>in</strong><br />

Etoposide<br />

Etoposide Phosphate<br />

Fludarab<strong>in</strong>e<br />

Gemcitab<strong>in</strong>e<br />

Idarubic<strong>in</strong><br />

Ifosfamide<br />

Ir<strong>in</strong>otecan<br />

Liposomal Daunorubic<strong>in</strong><br />

Liposomal Doxorubic<strong>in</strong><br />

Melphalan<br />

Methotrexate<br />

Mitomyc<strong>in</strong> C<br />

Mitozantrone<br />

Rituximab<br />

Thiotepa<br />

Topotecan<br />

V<strong>in</strong>blast<strong>in</strong>e<br />

V<strong>in</strong>crist<strong>in</strong>e<br />

V<strong>in</strong>des<strong>in</strong>e<br />

V<strong>in</strong>orelb<strong>in</strong>e<br />

Broad category<br />

Vesicant<br />

Neutral<br />

Non-vesicant/neutral<br />

Non-vesicant/neutral<br />

Irritants/<strong>in</strong>flammatants<br />

Vesicant<br />

Exfoliant. Treat as Irritants/<strong>in</strong>flammatants<br />

Non-vesicant/neutral<br />

Non-vesicant/neutral<br />

Non-vesicant/neutral<br />

Vesicant<br />

Vesicant<br />

Vesicant<br />

Vesicant<br />

Irritants/<strong>in</strong>flammatants<br />

Irritants/<strong>in</strong>flammatants<br />

Non-vesicant/neutral<br />

Non-vesicant/neutral<br />

Vesicant<br />

Non-vesicant/neutral<br />

Irritants/<strong>in</strong>flammatants<br />

Exfoliants/irritants/<strong>in</strong>flammatants. Treat as<br />

vesicant<br />

Exfoliants/irritants/<strong>in</strong>flammatants. Treat as<br />

vesicant<br />

Non-vesicant/neutral<br />

Irritants/<strong>in</strong>flammatants<br />

Vesicant<br />

Exfoliants/irritants/<strong>in</strong>flammatants. Treat as<br />

vesicant<br />

Non-vesicant/neutral<br />

Non-vesicant/neutral<br />

Exfoliants<br />

V<strong>in</strong>ca-alkaloids<br />

V<strong>in</strong>ca-alkaloids<br />

V<strong>in</strong>ca-alkaloids<br />

V<strong>in</strong>ca-alkaloids<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 15


Appendix 2: Non- <strong>Cytotoxic</strong> <strong>Extravasation</strong><br />

Determ<strong>in</strong>e which type <strong>of</strong> drug has extravasated, then us<strong>in</strong>g the table; follow the<br />

treatment procedure for that class <strong>of</strong> extravasated drug.<br />

IRRITANTS<br />

Adrenal<strong>in</strong>e<br />

(H)<br />

Amiodarone<br />

(C)<br />

Clarithromyc<strong>in</strong><br />

(C)<br />

Diazemuls<br />

(C)<br />

Dobutam<strong>in</strong>e<br />

(H)<br />

Dopam<strong>in</strong>e<br />

(H)<br />

Erythromyc<strong>in</strong><br />

(C)<br />

Foscarnet<br />

(C)<br />

Noradrenal<strong>in</strong>e<br />

(H)<br />

Phenobarbitone<br />

(C)<br />

Promethaz<strong>in</strong>e<br />

(C)<br />

Vancomyc<strong>in</strong><br />

(C)<br />

VESICANTS<br />

Aciclovir<br />

(C)<br />

Am<strong>in</strong>ophyll<strong>in</strong>e<br />

(H)<br />

Amphoteric<strong>in</strong><br />

(C)<br />

Calcium Chloride<br />

(H)<br />

Calcium Gluconate<br />

(H)<br />

Cefotaxime<br />

(C)<br />

Diazepam<br />

(C)<br />

Digox<strong>in</strong><br />

(C)<br />

Fluoresce<strong>in</strong><br />

(C)<br />

Ganciclovir<br />

(C)<br />

Hypertonic NaCl sol n > 5% (H)<br />

Phentolam<strong>in</strong>e<br />

(C)<br />

Parentral Nutrition<br />

(H)<br />

Phenyto<strong>in</strong><br />

(H)<br />

Potassium Chloride<br />

(>40mmols/l) (H)<br />

Sodium Bicarbonate<br />

(H)<br />

Ven<strong>of</strong>er<br />

(C)<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 16


Appendix 3 : <strong>Extravasation</strong> Kit Contents<br />

An <strong>Extravasation</strong> Kit is to be stored <strong>in</strong> all areas where the adm<strong>in</strong>istration <strong>of</strong><br />

cytotoxic drugs occurs. The kit conta<strong>in</strong>s all the drugs and equipment that<br />

maybe needed <strong>in</strong> the event <strong>of</strong> an extravasation. The kit should be checked<br />

regularly and re-supplied from pharmacy as required.<br />

Hyaluronidase 1500 units <strong>in</strong>jection.<br />

Chlorphenam<strong>in</strong>e 4mg tablets<br />

Hydrocortisone Sodium Phosphate <strong>in</strong>jection 100mg x 2<br />

Hydrocortisone 1% cream.<br />

Water for <strong>in</strong>jection (5ml).<br />

Heat Pad - <strong>in</strong>stant<br />

Cold Pad (<strong>in</strong> freezer on ward)<br />

2mL Syr<strong>in</strong>ges x 2<br />

19G needles x 2 (for draw<strong>in</strong>g up)<br />

25G needles x 4 (for <strong>in</strong>jection)<br />

Alcohol swabs<br />

10mL syr<strong>in</strong>ge x 1<br />

Indelible pen<br />

<strong>Extravasation</strong> policy<br />

<strong>Extravasation</strong> Report Card (Green Card)<br />

Patient <strong>in</strong>formation leaflet<br />

DMSO is not conta<strong>in</strong>ed <strong>in</strong> the kit but is available on Sennen ward, <strong>in</strong> the<br />

chemotherapy cupboard<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 17


Appendix 4 : Guidel<strong>in</strong>es for Best Practice When Adm<strong>in</strong>ister<strong>in</strong>g Intravenous Infusions<br />

Prevent<strong>in</strong>g<br />

<strong>Extravasation</strong><br />

<strong>in</strong> Infants and<br />

<strong>Children</strong> .<br />

Guidel<strong>in</strong>es<br />

for best<br />

practice.<br />

Assess the<br />

Risk<br />

Check the<br />

Site<br />

•<strong>Extravasation</strong> <strong>in</strong>jures are more common and severe <strong>in</strong> <strong>Children</strong> and Neonates.<br />

•Infants may not be able to localise or report pa<strong>in</strong>.<br />

•Confused and sedated patients are more at risk.<br />

•Does the patient have reduced sensation I.e. peripheral neuropathy.<br />

•Repeated <strong>in</strong>travenous <strong>in</strong>fusions and <strong>in</strong>jections <strong>in</strong>creases the risk. I.e. Ex premature<br />

babies who have had repeat cannulations.<br />

•Cover cannula site with designated transparent IV dress<strong>in</strong>g.<br />

•Select age appropriate dress<strong>in</strong>g. Spl<strong>in</strong>t / Tubigrip / Bandage. Do not apply too tightly.<br />

•Ensure <strong>in</strong>sertion site can be easily observed.<br />

•Check site hourly whilst <strong>in</strong>fusion is runn<strong>in</strong>g for:<br />

•Redness, Swell<strong>in</strong>g, Leak<strong>in</strong>g, Track<strong>in</strong>g, Loss <strong>of</strong> colour to limb, Pa<strong>in</strong> at site,<br />

St<strong>in</strong>g<strong>in</strong>g, Absent or sluggish blood return.<br />

•Verify patency <strong>of</strong> the site prior to the <strong>in</strong>fusion and hourly throughout. If there are any<br />

doubts STOP and INVESTIGATE. Resite the cannula if the patency <strong>of</strong> the cannulation<br />

is still not entirely satisfactory. NOTE: If extravasation suspected cannula should<br />

rema<strong>in</strong> <strong>in</strong> situe follow extravasation policy<br />

•Record location, condition <strong>of</strong> the site, verification <strong>of</strong> patency and patient responses.<br />

Report if necessary.<br />

•Parents should be asked if there are any new signs <strong>of</strong> irritability <strong>in</strong> their child dur<strong>in</strong>g<br />

<strong>in</strong>fusion.<br />

Check<br />

the<br />

Device<br />

•Check the device hourly and record: Prescribed rate, actual hourly rate, total volume <strong>in</strong>fused, pressure<br />

and alarm limits.<br />

•Check clamps, giv<strong>in</strong>g set and attachment to cannula are secure and correctly loaded <strong>in</strong>to the device.<br />

•Always check the site as well as the pump pressures. This should be done hourly. High pump<br />

pressures alone are not a reliable <strong>in</strong>dication <strong>of</strong> extravasation.<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review:<br />

•Pump pressures should be set at m<strong>in</strong>imum. Any changes should be documented and rational given.<br />

•Sign/Initial fluid chart to demonstrate checks carried out.<br />

18


Appendix 5: Patient Information Sheet<br />

UWhat is <strong>Extravasation</strong><br />

<strong>Extravasation</strong> is the leakage (or accidental <strong>in</strong>filtration) <strong>of</strong> drugs outside <strong>of</strong> the ve<strong>in</strong> and <strong>in</strong>to the<br />

surround<strong>in</strong>g tissues. With some drugs, this may lead to an immediate pa<strong>in</strong>ful reaction, and result <strong>in</strong><br />

local tissue damage.<br />

You may have noticed pa<strong>in</strong>; st<strong>in</strong>g<strong>in</strong>g, swell<strong>in</strong>g or other changes to the sk<strong>in</strong> at the site <strong>of</strong> drug<br />

adm<strong>in</strong>istration, or the nurse may have noticed that the drug was not flow<strong>in</strong>g <strong>in</strong> easily.<br />

UWhy did this happen<br />

Extrava sation is a rare but known complication <strong>of</strong> <strong>in</strong>travenous chemotherapy. It is impossible to<br />

prevent this even though we take all possible precautions. The important th<strong>in</strong>g is that it has been<br />

detected and treated.<br />

UWhy is extravasation a problem<br />

It can potentially lead to pa<strong>in</strong>, stiffness and tissue damage.<br />

UWhat treatment have I received to prevent tissue damage<br />

The nurse has given you the recommended treatment for the extravasation that you have<br />

experienced.<br />

You will have been <strong>in</strong>structed to apply either a cold or warm pack to the area for 20 m<strong>in</strong>utes, four<br />

times a day for two days.<br />

It is also advised to keep your arm elevated as much as possible.<br />

Although this will help to m<strong>in</strong>imise the chance <strong>of</strong> develop<strong>in</strong>g further problems, you will need to keep<br />

check<strong>in</strong>g the area every day.<br />

UCheck<strong>in</strong>g the area<br />

Once a day, check the area for the follow<strong>in</strong>g:<br />

• Has the area changed colour or <strong>in</strong>creased <strong>in</strong> redness<br />

• Is the area blister<strong>in</strong>g, peel<strong>in</strong>g or flak<strong>in</strong>g<br />

• Is the area more uncomfortable<br />

• Is the pa<strong>in</strong> mak<strong>in</strong>g it difficult for you to exercise the arm or hand<br />

What else do I need to do<br />

• Gently exercise the affected arm or hand.<br />

• Take mild pa<strong>in</strong>killers if required.<br />

• Do not apply any other lotions, creams or o<strong>in</strong>tments unless you have been <strong>in</strong>structed to do so by<br />

a doctor or nurse.<br />

• Do not expose the area to strong sunlight.<br />

• Avoid wear<strong>in</strong>g tight cloth<strong>in</strong>g around the affected area.<br />

• Protect the affected area when bath<strong>in</strong>g (or hav<strong>in</strong>g a shower) so that it does not get wet.<br />

When should I contact you<br />

If you answered YES to any <strong>of</strong> the questions <strong>in</strong> the checklist above, or if you have any other<br />

concerns, then you should contact Sennen ward (01872 252069)<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 19


Appendix 6 - References<br />

The National <strong>Extravasation</strong> Information Service. Protocol for <strong>Management</strong> <strong>of</strong><br />

Chemotherapy <strong>Extravasation</strong>. www.extravasation.org.uk<br />

Wendy Saegenschnitter, Vanessa McLelland (Bristol <strong>Children</strong>’s Hospital). Prescrib<strong>in</strong>g,<br />

Handl<strong>in</strong>g and Adm<strong>in</strong>istration <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> for Stem Cell Transplant and Paediatric<br />

Haematology & Oncology Patients. July 2010<br />

NOTE: This guidel<strong>in</strong>e is an adaption <strong>of</strong> the Royal Cornwall Hospitals Trust document<br />

“<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> Adults” produced by Lisa Nicholls,<br />

Cl<strong>in</strong>ical Nurse Specialist <strong>in</strong> Cancer care,<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 20


Appendix 7.Initial Equality Impact Assessment Screen<strong>in</strong>g Form<br />

Name <strong>of</strong> service, strategy, policy or project (hereafter referred to as policy) to be<br />

assessed: <strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Directorate and service area:<br />

Child Health<br />

Name <strong>of</strong> <strong>in</strong>dividual complet<strong>in</strong>g<br />

assessment: Sabr<strong>in</strong>a Tierney<br />

Is this a new or exist<strong>in</strong>g Procedure<br />

Exist<strong>in</strong>g<br />

Telephone: 01872 252590<br />

1. Procedure Aim* To provide cl<strong>in</strong>ical staff with clear guidel<strong>in</strong>es on the care <strong>of</strong><br />

patients who have experienced an extravasation<br />

2. Procedure Objectives* To provide a basis for the nurs<strong>in</strong>g care that is required for<br />

patients that have experienced an extravasation<br />

3. Procedure – <strong>in</strong>tended<br />

Outcomes*<br />

<strong>Extravasation</strong> is treated <strong>in</strong> a safe manner<br />

4. How will you measure<br />

the outcome<br />

5. Who is <strong>in</strong>tended to<br />

benefit from the<br />

Procedure<br />

6a. Is consultation<br />

required with the<br />

workforce, equality<br />

groups etc. around this<br />

procedure<br />

b. If yes, have these<br />

groups been consulted<br />

c. Please list any groups<br />

who have been consulted<br />

about this procedure.<br />

All staff <strong>in</strong>volved <strong>in</strong> the giv<strong>in</strong>g <strong>of</strong> chemotherapy<br />

Yes<br />

Yes<br />

Paediatric Oncology MDT<br />

Paediatric Guidel<strong>in</strong>es Committee<br />

*Please see Glossary<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 21


7. The Impact<br />

Please complete the follow<strong>in</strong>g table us<strong>in</strong>g ticks. You should refer to the EIA guidance<br />

notes for areas <strong>of</strong> possible impact and also the Glossary if needed.<br />

Where you th<strong>in</strong>k that the policy could have a positive impact on any <strong>of</strong> the equality<br />

group(s) like promot<strong>in</strong>g equality and equal opportunities or improv<strong>in</strong>g relations<br />

with<strong>in</strong> equality groups, tick the ‘Positive impact’ box.<br />

Where you th<strong>in</strong>k that the policy could have a negative impact on any <strong>of</strong> the equality<br />

group(s) i.e. it could disadvantage them, tick the ‘Negative impact’ box.<br />

Where you th<strong>in</strong>k that the policy has no impact on any <strong>of</strong> the equality group(s) listed<br />

below i.e. it has no effect currently on equality groups, tick the ‘No impact’ box.<br />

Equality<br />

Group<br />

Age<br />

Disability<br />

Faith and<br />

Belief<br />

Gender<br />

Race<br />

Sexual<br />

Orientation<br />

Positive<br />

Impact<br />

Negative<br />

Impact<br />

No<br />

Impact<br />

<br />

<br />

<br />

<br />

<br />

<br />

Reasons for decision<br />

Procedure available to all patients<br />

who require treatment.<br />

Procedure available to all patients<br />

who require treatment.<br />

Procedure available to all patients<br />

who require treatment.<br />

Procedure available to all patients<br />

who require treatment.<br />

Procedure available to all patients<br />

who require treatment.<br />

Procedure available to all patients<br />

who require treatment.<br />

You will need to cont<strong>in</strong>ue to a full Equality Impact Assessment if the follow<strong>in</strong>g have<br />

been highlighted:<br />

A negative impact and<br />

No consultation (this excludes any policies which have been identified as not<br />

requir<strong>in</strong>g consultation).<br />

8. If there is no evidence that<br />

the policy promotes equality,<br />

equal opportunities or improved<br />

relations - could it be adapted<br />

so that it does How<br />

Full statement <strong>of</strong> commitment to policy <strong>of</strong><br />

equal opportunities is <strong>in</strong>cluded <strong>in</strong> the policy<br />

Please sign and date this form.<br />

Keep one copy and send a copy to the Human Resources Team, c/o<br />

Royal Cornwall Hospitals NHS Trust, Human Resources Department, Lamorna House,<br />

Penvent<strong>in</strong>nie Lane, Truro, Cornwall, TR1 3LJ<br />

They will<br />

arrange for a summary <strong>of</strong> the results to be published on the Trust’s web site.<br />

Signed ________________________________________<br />

Date _________________________________________<br />

<strong>Management</strong> <strong>of</strong> <strong>Extravasation</strong> <strong>of</strong> <strong>Cytotoxic</strong> <strong>Drugs</strong> <strong>in</strong> <strong>Children</strong><br />

Ratified: Review: 22

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