A Study of the Arterial Stiffness Index in Diabetes ... - Vital-Age GmbH

A Study of the Arterial Stiffness Index in Diabetes Patients:
Trial of a New Non-Invasive Arterial Hardness Estimation Procedure that Uses an
Oscillometric Method
Third Department of Internal Medicine, Tokyo Medical University School of Medicine 1 ,
Kyorin University School of Health Sciences 2 , Department of General Medicine, Kyorin University School of
Medicine 3 , Tokyo Metropolitan Toshima Hospital, Department of Internal Medicine 4 , National Public Service
personnel mutual Aid Associations Federation Tachikawa Hospital, Health Medicine Center 5
Kazuhiro Hiramine 1 , Takashi Miwa 1 , Keiichiro Harashima 2 , Toshiaki Takeichi 3 , Naoko Iwahashi 1 ,
Rie Kubota 4 , Rokurou Ito 4 , Masao Kanazawa 1 , Yoko Notoya 1 , Hideaki Sato 5 , Hideaki Shimazu 2 ,
Juinchi Hayashi 3 , Toru Hayashi 1
Presented at the Japan Diabetes Society, May 2002
Introduction:
The CardioVision Model MS-2000 (distributed by IMDP Corporation USA) system
applies the oscillometric method to measure arterial stiffness, which is quantified by
the Arterial Stiffness Index (ASI). Using this device, we compared arterial stiffness in
diabetes and non-diabetes patients.
Subjects and Method:
202 outpatients with Type 2 diabetes participated in this study. 54 regular medical
checkup patients participated as a control group. ASI measurement was
conducted with the subject in a sitting position and rested state and was repeated
for each subject 3 to 5 times.
Result:
The diabetes patients’ ASI of 104 was significantly higher than the non-diabetes
patients’ ASI of 41. A strong correlation with age, blood pressure, and BMI was also
noted. When we categorized diabetes subjects by general danger factors, those
patients who also had high blood pressure demonstrated a prominent increased
ASI score.
Observations:
Diabetes patients demonstrated significantly increased arterial stiffness. As data
accumulates, we expect that the ASI system will emerge as a new non-invasive
standard for measuring arterial stiffness.

Slide 11
健 常 者 と 糖 尿 病 患 者 のASI
200
160
(∗) P

Slide 12
健 常 者 と 糖 尿 病 患 者 のASI
240
200
160
120
80
40
0
42 55
健 常 者
DM
(∗
)
(∗)P

Slide 15
○1
ASI 正 常 ・ 異 常 群 の 各 指 標
○2
ASI正 常 群
ASI異 常 群
○3
○4
収 縮 期 血 圧
140±22
162±23
P

Slide 1
550
450
ASIと 各 臨 床 指 標 の 相 関
血 糖
収 縮 期 血 圧
測 定 者 全 員 のデータ
T-cho
550
550
Y = 73.31 + .135 * X; R^2 = .007
Y = -224.898 + 2.192 * X; R^2 = .299
Y = 54.661 + .197 * X; R^2 = .006
450
450
350
350
350
ASI
250
ASI
250
ASI
250
150
150
150
50
50
50
-50
0 50 100 150 200 250 300 350 400 450 500
[mg/dl]
-50
60 80 100 120 140 160 180 200 220 240
[mmHg]
-50
50 100 150 200 250 300 350 400
[mg/dl]
550
HbA1c
Y = 83.531 + 1.531 * X; R^2 = .001
550
拡 張 期 血 圧
Y = 97.9 - .047 * X; R^2 = 3.813E-5
550
LDL-cho
Y = 70.369 + .199 * X; R^2 = .005
450
450
450
350
350
350
ASI
250
ASI
250
ASI
250
150
150
150
50
50
50
-50
2 4 6 8 10 12 14 16 18
-50
20 30 40 50 60 70 80 90 100 110 120 130
-50
0 50 100 150 200 250 300
[%]
[mmHg]
[mg/dl]
○1 ○2 ○3 ○4 ○5
English
○1 Correlation between ASI and each clinical index
○2 Blood sugar
○3 Systolic blood pressure
○4 Diastolic blood pressure
○5
Data for all measurement recipients

Slide 2
550
ASIと 各 臨 床 指 標 の 相 関
今 回 使 用 したDM 患 者 のみのデータ
血 糖
収 縮 期 血 圧
T-cho
550
550
Y = 90.542 + .045 * X; R^2 = .001
Y = -226.834 + 2.208 * X; R^2 = .304
Y = 27.411 + .345 * X; R^2 = .017
450
450
450
350
350
350
ASI
250
ASI
250
ASI
250
150
150
150
50
50
50
-50
0 50 100 150 200 250 300 350 400 450 500
[mg/dl]
550
HbA1c
Y = 89.864 + 1.108 * X; R^2 = 3.853E-4
-50
80 100 120 140 160 180 200 220 240
[mmHg]
拡 張 期 血 圧
550
Y = 70.116 + .373 * X; R^2 = .002
-50
50 100 150 200 250 300 350 400
[mg/dl]
LDL-cho
550
Y = 55.526 + .34 * X; R^2 = .014
450
450
450
350
350
350
ASI
250
ASI
250
ASI
250
150
150
150
50
50
50
-50
4 6 8 10 12 14 16 18
[%]
-50
20 30 40 50 60 70 80 90 100 110 120
[mmHg]
-50
0 25 50 75 100 125 150 175 200 225 250
[mg/dl]
○1 ○2 ○3 ○4 ○5
English
○1 Correlation between ASI and each clinical index
○2 Blood sugar
○3 Systolic blood pressure
○4 Diastolic blood pressure
○5
The data for DM patients used (in this study)