ARCHITECT® HIV Ag/Ab Combo: Moving HIV ... - The AIDS Institute

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Seattle Study Stekler JD, et al, Clin Infectious Diseases 2009; 49:444-453 MSM population – high risk, frequent testing Specimens collected at Public Health-Seattle and King County 2003-2008 specimens screened N=14,005 • HIV antibody positive N=328 (2.3%) • HIV Ab-/RNA+ (acute) N=36 (0.3%) NAT algorithm increased yield of HIV infection by 11% Median time from collection to report of NAT+ result: 16-19 days 10
Seattle Combo Results 16 of 36 acute HIV specimens available for ARCHITECT HIV Combo testing HIV Combo detected 15 of 16 (94%) HIV RNA for Combo negative: 4,946 copies/mL Median HIV RNA for Combo positive: 4.5 million copies/mL *RealTime HIV-1 assay performed using residual specimen volume Specimen ID HIV-1 EIA s/co ARCHITECT Combo s/co HIV RNA copies/mL* 47 0.18 0.2 4,946 9 0.4 2.17 133,120 10 nd 2.68 284,605 12 nd 5.09 483,329 11 0.3 9.85 1,133,033 45 0.24 10.36 637,151 16 0.08 21.32 1,714,915 42 0.02 36.31 5,678,616 41 0.59 36.43 4,510,685 43 0.12 42.75 5,678,616 44 0.25 45.87 4,510,685 48 0.14 54.55 8,795,135 46 0.19 80.68 22,092,380 14 0.6 101.6 26,560,883 13 0.5 108.9 6,519,924 15 0.4 463.4 >90,000,000 11
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Page 5 and 6: ARCHITECT HIV Ag/Ab Combo • First
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Page 15 and 16: Reduction in Seroconversion Window
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ARCHITECT® HIV Ag/Ab Combo: Moving HIV ... - The AIDS Institute

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