ARCHITECT® HIV Ag/Ab Combo: Moving HIV ... - The AIDS Institute
ARCHITECT® HIV Ag/Ab Combo: Moving HIV ... - The AIDS Institute
ARCHITECT® HIV Ag/Ab Combo: Moving HIV ... - The AIDS Institute
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What is Acute Phase of <strong>HIV</strong> Infection<br />
Appearance of markers of <strong>HIV</strong> infection<br />
AHI<br />
<strong>HIV</strong> RNA<br />
(plasma)<br />
Anti-<strong>HIV</strong> <strong>Ab</strong><br />
<strong>HIV</strong> p24 <strong>Ag</strong><br />
0 10 20 30 40 50 60 70 80 90 100<br />
Day post infection<br />
• <strong>Ab</strong>sence of <strong>HIV</strong> specific antibodies<br />
• Rapid rise in plasma viremia<br />
• Acute viral syndrome: fever, rash, diarrhea, fatigue, headache –<br />
opportunity for <strong>HIV</strong> testing<br />
• Detect AHI by NAT or p24 antigen<br />
Fiebig et al <strong>AIDS</strong>, 17:1871-1879 (2003)<br />
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