University of Paris, CNRS Department of Epigenetics and Cell Fate

University of Paris, CNRS
Department of Epigenetics and Cell Fate
POST-DOCTORAL POSITION
A post-doctoral position is available at CNRS in Paris, France, to study epigenetic
regulators in mammalian cells.
We study DNA methylation and the proteins that recognize this epigenetic mark in
mammalian cells. The project funded focuses on UHRF1, an essential epigenetic actor
that links DNA methylation to histone modifications. We seek to understand its role in
development and cancer.
Our lab is part of a biology department devoted to Epigenetics and Cell Fate. The
workplace is international and the working language is English. We are located in a new
research facility in Paris proper. Visit our website http://parisepigenetics.com/ for more
details on the lab and our research interests.
A doctoral degree, experience in cellular and molecular biology, and proficiency in
English, are required. Candidates must be highly motivated and have a successful track
record.
Postdoctoral funding is available for up to three years. The gross monthly salary is
2200-2500 Euros, commensurate with experience. This allows for comfortable living in
Paris.
To apply, please send your CV, a motivation letter, and the names of two references to:
Pierre-Antoine.Defossez@univ-paris-diderot.fr

Recent publications from the lab:
A new family of human proteins that bind methylated DNA and repress transcription.
Filion et al, Molecular and Cellular Biology, (2006)
Assessment of sera for Chromatin-Immunoprecipitation.
Nguyen J., et al BioTechniques (2008)
ZBTB4 represses transcription of p21CIP1 and controls the cellular response to p53.
Weber et al EMBO J, (2008)
The cell biology of DNA methylation
Prokhortchouk E. and Defossez P.A.
Biochim Biophys Acta. (2008)
Many paths to one goal The proteins that bind methylated DNA in eukaryotes
Sasai et al Int. J. Dev. Biol., (2009)
The human protein kinase HIPK2 phosphorylates and downregulates the methylbinding
transcription factor ZBTB4.
Yamada et al Oncogene, (2009)
Sequence-specific recognition of methylated by human Zinc finger proteins.
Sasai et al Nucleic Acids Research, (2010).
The human proteins MBD5 and MBD6 associate with heterochromatin but do not
bind methylated DNA.
Laget et al, PLoS ONE (2010).
Mammalian Methyl-Binding Proteins: what might they do
Joulie et al BioEssays, in press.