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POLE HOSPITALIER<br />

MEDECINE ET REANIMATION NEONATALE<br />

CHEF DE PÔLE : Professeur Umberto SIMEONI<br />

ADRESSE : Hôpital de LA CONCEPTION , service de NEONATOLOGIE, 147 boulevard Baille 13385<br />

MARSEILLE cédex 05<br />

TELEPHONE : 04 91 38 40 40<br />

COURRIEL : umberto.simeoni@ap-hm.fr<br />

ECOLE DOCTORALE : Sciences de la Vie <strong>et</strong> de la Santé<br />

RATTACHEMENTS : UMR INSERM 1076<br />

DISCIPLINES D’APPARTENANCES : PEDIATRIE<br />

SPECIALITÉS : NEONATOLOGIE<br />

EFFECTIFS<br />

Enseignants-Chercheurs (PU-PH, MCU-PH, CCA, AHU) :<br />

Personnel Hospitalier (PH, Attaché) :<br />

1 PU-PH,<br />

4 CCA<br />

20 PH temps plein ou temps partiel,<br />

7 attachés<br />

Personnel Technique : 0<br />

Personnel Administratif :<br />

Etudiants :<br />

6,5 Assistantes médico-administratives<br />

5 internes DES/DESC à la Conception,<br />

4 internes à l’Hôpital Nord,<br />

9 DCEM3 <strong>et</strong> 5 DCEM4 à la Conception<br />

PERSONNELS RATTACHÉS A UNE EQUIPE DE RECHERCHE<br />

NOMS : FONCTIONS :<br />

Aix-Marseille Université, UMR INSERM 1076, Faculté de Pharmacie, Marseille<br />

Pr Umberto SIMEONI,<br />

PU-PH,<br />

Dr Isabelle GRANDVUILLEMIN,<br />

CCA<br />

Dr Naïs BASCHET,<br />

CCA<br />

Dr Isabelle LIGI,<br />

PH<br />

Laboratoire de Santé Publique. Evaluation des systèmes de soins <strong>et</strong> santé perçue. UFR Médecine<br />

site <strong>Timone</strong> :<br />

Dr AUQIER Pascal<br />

PU-PH<br />

Pôle <strong>hospitalier</strong>. Médecine <strong>et</strong> Réanimation Néonatale 1/5


Aix-Marseille Université, UMR 7268, Anthropologie bio-culturelle, Droit, Ethique <strong>et</strong> Santé (ADES) :<br />

Dr EINAUDI Marie Ange<br />

PH<br />

INMED – Epilepsie <strong>et</strong> Ischémie cérébrale. Sciences <strong>et</strong> vie de la santé, département biologie,<br />

médecine <strong>et</strong> santé spécialité neursocience :<br />

Dr BREVAUT Véronique<br />

SERVICES HOSPITALIERS<br />

INTITULÉ : Service de NEONATOLOGIE, Hôpital de la CONCEPTION<br />

RESPONSABLE : Professeur Umberto SIMEONI<br />

DISCIPLINE :<br />

INTITULÉ : Service de NEONATOLOGIE, Hôpital NORD<br />

RESPONSABLE : Professeur Umberto SIMEONI<br />

DISCIPLINE :<br />

PUBLICATIONS ANNÉES 2010 <strong>et</strong> 2011<br />

Année 2010<br />

Ligi I, Mill<strong>et</strong> V, Sartor C, Jouve E, Tardieu S, Sambuc R, Simeoni U. Iatrogenic events in neonates :<br />

beneficial effects of prevention strategies and continuous monitoring. Pediatrics. 2010; 126:e1461-<br />

8.<br />

Skupski DW, Chervenak FA, McCullough LB, Bancalari E, Haumont D, Simeoni U, Saugstad O, Dohn<br />

S, Arabin B, Greenough A, Donzelli G, Levene M, Sen C, Carbonell X, Dudenhausen JW, Vladareanu<br />

R, Antsalakis A, Papp Z, Aksit M, Carrapato M. Ethical dimensions of periviability. J Perinat Med.<br />

2010; 38:579-83.<br />

Sandri F, Plavka R, Ancora G, Simeoni U, Stranak Z, Martinelli S, mosca F, nona J, Thomson M,<br />

Verder H, Fabbri l, Halliday H, Prophylactic or early selective surfactant combined with nCPAP in<br />

very pr<strong>et</strong>erm infants. Pediatrics. 2010 ; 125: e1402-9.<br />

Simeoni U, Boubred F, Buffat C, Grandvuillemin I, Ligi I. Risk for long term disease in low birth<br />

weight infants. Arch pediatr. 2010; 17: 669-670.<br />

Swe<strong>et</strong> DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, Saugstad OD, Simeoni U, Speer<br />

CP, Halliday HL; European Association of Perinatal Medicine. European consensus guidelines on the<br />

management of neonatal respiratory distress syndrome in pr<strong>et</strong>erm infants 2010 update.<br />

Neonatology. 2010; 97:402-17.<br />

Ligi I, Grandvuillemin I, Andres V, Dignat-George F, Simeoni U. Low Birth Weight Infants and the<br />

Developmental Programming of Hypertension : A Focus on Vascular Factors. Semin Perinatol.<br />

2010;34:188-192.<br />

Mori<strong>et</strong>te G, Rameix S, Azria E, Fournié A, Andrini P, Caeymaex L, Dageville C, Gold F, Kuhn P,<br />

Storme L, Simeoni U Very premature births: Dilemmas and management. Part 1. Outcome of<br />

infants born before 28 weeks of postmenstrual age, and definition of a gray zone. Groupe de<br />

réflexion sur les aspects éthiques de la périnatologie. Arch Pediatr. 2010;17:518-26<br />

Mori<strong>et</strong>te G, Rameix S, Azria E, Fournié A, Andrini P, Caeymaex L, Dageville C, Gold F, Kuhn P,<br />

Storme L, Simeoni U. Very premature births: Dilemmas and management. Second part: Ethical<br />

aspects and recommendations. Groupe de réflexion sur les aspects éthiques de la périnatologie.<br />

Arch Pediatr. 2010;17:527-39.<br />

Bétrémieux P, Gold F, Parat S, Farnoux C, Rajguru M, Boithias C, Mahieu-Caputo D, Jouannic JM,<br />

Hubert P, Simeoni U. Implementing palliative care for newborns in various care s<strong>et</strong>tings. Part 3 of<br />

"Palliative care in the neonatal period". Arch Pediatr. 2010;17:420-5.<br />

Pôle <strong>hospitalier</strong>. Médecine <strong>et</strong> Réanimation Néonatale 2/5


Gascoin-Lachambre G, Buffat C, Rebourc<strong>et</strong> R, Chelbi ST, Rigourd V, Mondon F, Mignot TM, Legras<br />

E, Simeoni U, Vaiman D, Barbaux S. Cullins in human intra-uterine growth restriction: expressional<br />

and epigen<strong>et</strong>ic alterations. Placenta. 2010;31:151-7.<br />

C Lepeytre, V Lacroze, M Capelle, R Nicollas, U Simeoni, L Fayol. Severe, multiple congenital<br />

malformations after short carbimazole exposure. Journal of Neonatal-Perinatal Medicine<br />

2010;3:347-9<br />

Mazeiras G, des Robert C, Legrand A, Caillaux G, Corre A, Rozé JC, Flamant C. Cobedding for<br />

premature twins. Soins Pediatr Pueric. 2010 ;(254):20-2.<br />

Colombani M, Ferry M, Toga C, Lacroze V, Rubesova E, Barth RA, Cassart M, Gorincour G.<br />

Magn<strong>et</strong>ic resonance imaging in the prenatal diagnosis of congenital diarrhea. Ultrasound Obst<strong>et</strong><br />

Gynecol. 2010 ;35(5):560-5.<br />

Fernandez C, Halbert C, De Paula AM, Lacroze V, Froissart R, Figarella-Branger D, Chabrol B,<br />

Pellissier JF. Non-l<strong>et</strong>hal neonatal neuromuscular variant of glycogenosis type IV with novel GBE1<br />

mutations. Muscle Nerve 2010 ;41(2):269-71.<br />

Perr<strong>et</strong>-Court A, Fernandez C, Monestier S, Mill<strong>et</strong> V, Tasei AM. Placental m<strong>et</strong>astasis of melanoma : a<br />

new case and literature review. Ann Pathol. 2010 ;30(2):143-6.<br />

Husson B, Hertz-Pannier L, Renaud C, Allard D, Presles E, Landrieu P, Chabrier S; - Motor<br />

outcomes after neonatal arterial ischemic stroke related to early MRI data in a prospective<br />

study.AVCnn Group.Pediatrics. 2010 ;126(4):912-8.<br />

Renaud C, Tardy-Ponc<strong>et</strong> B, Presles E, Chabrier S. Low prevalence of coagulation F2 and F5<br />

polymorphisms in mothers and children in a large cohort of patients with neonatal arterial ischemic<br />

stroke. AVCnn group.Br J Haematol. 2010 ;150(6):709-12.<br />

Renaud C, Bonneau C, Presles E, Laporte S, Depeyre A, Varl<strong>et</strong> MN, Chabrier S. Lipoprotein (a),<br />

birth weight and neonatal stroke. AVCnn Group.Neonatology. 2010;98(3):225-8.<br />

Wallon M, Franck J, Thulliez P, Huissoud C, Peyron F, Garcia-Meric P, Kieffer F. Accuracy of realtime<br />

polymerase chain reaction for Toxoplasma gondii in amniotic fluid.Obst<strong>et</strong> Gynecol. 2010<br />

;115(4):727-33.<br />

Einaudi MA, Le Coz P, Malzac P, Michel F, D'Ercole C, Gire C. Parental experience following perinatal<br />

death: exploring the issues to make progress. Eur J Obst<strong>et</strong> Gynecol Reprod Biol. 2010<br />

;151(2):143-8.<br />

Brévaut-Malaty V, Busuttil M, Einaudi MA, Monnier AS, D'Ercole C, Gire C.Eur J Longitudinal followup<br />

of a cohort of 350 singl<strong>et</strong>on infants born at less than 32 weeks of amenorrhea: neurocognitive<br />

screening, academic outcome, and perinatal factors.Obst<strong>et</strong> Gynecol Reprod Biol. 2010 ;150(1):13-<br />

8.<br />

Carbonell-Estrany X, Simões EA, Dagan R, Hall CB, Harris B, Hultquist M, Connor EM, Losonsky GA.<br />

Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority<br />

trial. Motavizumab Study Group.Pediatrics. 2010;125(1):e35-51.<br />

Santos A, Dur<strong>et</strong> M, Mancini J, Busuttil M, Deruelle C. Does pr<strong>et</strong>erm birth affect global and<br />

configural processing differently Dev Med Child Neurol. 2010 ;52(3):293-8.<br />

Année 2011<br />

Simeoni U, Ligi I, Grandvuillemin I, Boubred F. Early origins of arterial hypertension and<br />

cardiovascular diseases. Bull Acad Natl Med. 2011;195:499-508; discussion 508-10.<br />

Lapillonne A, Fellous L, Kermorvant-Duchemin E; French neonatal departments. Use of parenteral<br />

lipid emulsions in French neonatal ICUs. Nutr Clin Pract. 2011 ;26:672-80.<br />

Pôle <strong>hospitalier</strong>. Médecine <strong>et</strong> Réanimation Néonatale 3/5


Gaborit B, Kober F, Jacquier A, Moro PJ, Flavian A, Quilici J, Cuiss<strong>et</strong> T, Simeoni U, Cozzone P, Alessi<br />

MC, Clément K, Bernard M, Dutour A. Epicardial Fat Volume Is Associated With Coronary<br />

Microvascular Response in Healthy Subjects: A Pilot Study. Obesity. 2011; doi:<br />

10.1038/oby.2011.283.<br />

Garcia C, Mill<strong>et</strong> V, Coste TC, Mimoun M, Rid<strong>et</strong> A, Antona C, Simeoni U, Armand M. French mothers'<br />

milk deficient in DHA contains phospholipid species of potential interest for infant development. J<br />

Pediatr Gastroenterol Nutr. 2011;53:206-12.<br />

Vaiman D, Gascoin-Lachambre G, Boubred F, Mondon F, Feuerstein JM, Ligi I, Grandvuillemin I,<br />

Barbaux S, Ghigo E, Achard V, Simeoni U, Buffat C. The intensity of IUGR-induced transcriptome<br />

deregulations is inversely correlated with the ons<strong>et</strong> of organ function in a rat model. PLoS One.<br />

2011;6:e21222.<br />

Ligi I, Simoncini S, Tellier E, Vassallo PF, Sabatier F, Guill<strong>et</strong> B, Lamy E, Sarlon G, Quemener C,<br />

Bikfalvi A, Marcelli M, Pascal A, Dizier B, Simeoni U, Dignat-George F, Anfosso F. A switch toward<br />

angiostatic gene expression impairs the angiogenic properties of endothelial progenitor cells in low<br />

birth weight pr<strong>et</strong>erm infants. Blood. 2011;118:1699-709.<br />

Feltes TF, Sondheimer HM, Tulloh RM, Harris BS, Jensen KM, Losonsky GA, Griffin MP;<br />

Motavizumab Cardiac Study Group. A randomized controlled trial of motavizumab versus<br />

palivizumab for the prophylaxis of serious respiratory syncytial virus disease in children with<br />

hemodynamically significant congenital heart disease. Pediatr Res. 2011;70:186-91.<br />

Dageville C, Bétrémieux P, Gold F, Simeoni U; Working Group on Ethical Issues in Perinatology.<br />

The French Soci<strong>et</strong>y of Neonatology's proposals for neonatal end-of-life decision-making.<br />

Neonatology. 2011;100:206-14.<br />

Swe<strong>et</strong> DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, Saugstad OD, Simeoni U, Speer<br />

CP, Halliday HL. [European consensus guidelines on the management of neonatal respiratory<br />

distress syndrome in pr<strong>et</strong>erm infants-2010 update]. Zhonghua Er Ke Za Zhi. 2011;49:27-33.<br />

Andres V, Garcia P, Rim<strong>et</strong> Y, Nicaise C, Simeoni U. Apparent life-threatening events in presumably<br />

healthy newborns during early skin-to-skin contact. Pediatrics. 2011;127 ; 1073-6.<br />

Gorincour G, Tassy S, Siméoni U, Le Coz P. Ethical issues on pregnancy termination: impact of new<br />

imaging modalities. F<strong>et</strong>al Diagn Ther. 2011;30:1-8.<br />

Lapillonne A, Razafimahefa H, Rigourd V, Granier M; intervenants au séminaire Nutrition du<br />

prématuré du GEN-IdF. [Nutrition of the pr<strong>et</strong>erm infant]. Arch Pediatr. 2011;18:313-23.<br />

Ligi I, Boubred F, Grandvuillemin I, Simeoni U. Clinical research in newborn infants: difficulties and<br />

specificity. Eur J Clin Pharmacol. 2011;67 Suppl 1:29-32.<br />

Simeoni U, Ligi I, Buffat C, Boubred F. Adverse consequences of accelerated neonatal growth:<br />

cardiovascular and renal issues. Pediatr Nephrol. 2011;26:493-508.<br />

Lapillonne A, Fellous L, Kermorvant-Duchemin E. Use of parenteral lipid emulsions in French<br />

neonatal ICUs.Nutr Clin Pract. 2011 ;26(6):672-80.<br />

Gasior N, David M, Mill<strong>et</strong> V, Reynaud-Gaubert M, Dubus JC.<br />

premature birth. Rev Mal Respir. 2011 ;28(10):1329-39.<br />

Adult respiratory sequelae of<br />

L Fayol, I Mercanti, F Arnaud. Morbidité à court terme : pathologie respiratoire, apnées, troubles<br />

hémodynamiques, oxygénation tissulaire, persistance du canal artériel. EMC Pédiatrie - Maladies<br />

infectieuses 2011<br />

Wallon M, Kieffer F, Binqu<strong>et</strong> C, Thulliez P, Garcia-Méric P, Dureau P, Franck J, Peyron F, Bonnin A,<br />

Villena I, Bonithon-Kopp C, Gouyon JB, Masson S, Félin A, Cornu C. Congenital toxoplasmosis:<br />

randomised comparison of strategies for r<strong>et</strong>inochoroiditis prevention.Therapie. 2011 ;66(6):473-<br />

80.<br />

Farnault L, Garcia-Meric P, Cortey A, Arnaud F F<strong>et</strong>omaternal anti-RH3, -4 (anti-E and anti-c) rhesus<br />

isoimmunization: a case report.Arch Pediatr. 2011 ;18(2):176-82.<br />

Pôle <strong>hospitalier</strong>. Médecine <strong>et</strong> Réanimation Néonatale 4/5


Zahed-Cheikh M, Brévaut-Malaty V, Busuttil M, Monnier AS, Roussel M, Gire C. Comparative<br />

analysis of perinatal and postnatal factors, and general movement in extremely pr<strong>et</strong>erm infants.<br />

Brain Dev. 2011;33(8):656-65.<br />

Garcia-Méric P, Franck J, Dumon H, Piarroux R. Management of congenital toxoplasmosis in<br />

France: current data.Presse Med. 2010 May;39(5):530-8. Vignoles P, Gire C, Mancini J, Br<strong>et</strong>elle F,<br />

Boubli L, Janky E, Carcopino X. Arch Gestational diab<strong>et</strong>es: a strong independent risk factor for<br />

severe neonatal respiratory failure after 34 weeks. Gynecol Obst<strong>et</strong>. 2011 ;284(5):1099-104.<br />

CONTRATS ANNÉES 2010 <strong>et</strong> 2011<br />

Professeur Umberto SIMEONI<br />

Thérapie cellulaire de l’asphyxie néonatale par les cellules souches du sang du cordon autologue,<br />

2010.<br />

PHRC National<br />

Professeur Umberto SIMEONI<br />

Thérapie cellulaire de l’asphyxie néonatale par les cellules souches du sang du cordon autologue,<br />

2010.<br />

Contrat AP-HM AORC excellence<br />

Docteur Laurence Fayol<br />

Promotion AP-HM 2011 (Référence Promoteur 2011-13 ; Accord CPP Sud méditerranée I le<br />

23/08/2011 référence 1129 ; Autorisation AFsSSAPS le 10/06/2011, référence B11701-90) :<br />

Influence de la morbidité <strong>et</strong> des thérapeutiques sur la bilirubine non liée à l’albumine chez le<br />

nouveau-né prématuré.<br />

Docteur Catherine GIRE. Promotion APHM 2011 : « Exposition à une odeur familière : lait maternel<br />

<strong>et</strong> analgésie »<br />

Docteur Marie-Ange EINAUDI : Connaissances perceptions <strong>et</strong> attentes des médecins face à QV des<br />

TG prématurés (AORC 2010)<br />

Docteur Véronique BREVAUT. AORC 2010 : Eff<strong>et</strong> de différentes techniques de stimulation par<br />

pression cutanée, avec ou sans huile, sur le développement neurologique à court <strong>et</strong> moyen terme<br />

dans une population de grands prématurés.<br />

THESES de DOCTORAT ANNÉES 2010 <strong>et</strong> 2011<br />

Année 2010<br />

BOUBRED Farid « Conséquences vasculaires <strong>et</strong> rénales à long terme de la restriction de croissance<br />

intra-utérine <strong>et</strong> de la nutrition post-natale chez le rat ». 24/11/2010 (thèse Université).<br />

Année 2011<br />

BASCHET Naïs « Oxymétrie régionale par Near Infrared Spectroscopy (NIRS) chez le nouveau-né<br />

en situations hémodynamiques précaires. 5/05/2011 (thèse Faculté de Médecine).<br />

n°10 04291, 2 novembre 2010<br />

Univ Aix-Marseille II, AP-HM<br />

Simulation pour l’intubation trachéale<br />

BREVETS ANNÉES 2010 <strong>et</strong> 2011<br />

Pôle <strong>hospitalier</strong>. Médecine <strong>et</strong> Réanimation Néonatale 5/5

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