Methods for the determination of the hazardous properties - TSAR

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This document was prepared from the draft paper sent for publication and is provided as informative material only. Possibility of errors cannot be excluded although care has been taken to avoid them. In case of doubt, please refer to the published paper (report EUR 18748 (1999))or contact the editors. INDEX I. Introduction/Background.............................................................................................................5 II. Protocols.........................................................................................................................................9 II.1 Biopersistence of Fibres. Short Term Exposure by Inhalation (ECB/TM/26 rev. 7)......11 II.2 Biopersistence of Fibres. Intratracheal Instillation (ECB/TM/27 rev.7).........................25 II.3 Carcinogenicity of Synthetic Mineral Fibres after Intraperitoneal Injection in Rats (ECB/TM/18(97) rev. 1)........................................................................................................41 II.4 Chronic Inhalation Toxicity of Synthetic Mineral Fibres in Rats (ECB/TM/17(97) rev.2).........................................................................................................53 II.5 Sub-chronic Inhalation Toxicity of Synthetic Mineral Fibres in Rats (ECB/TM/16(97) rev. 1)........................................................................................................69 Annexes.............................................................................................................................................85 . Annex 1: Guidance Notes on Preparation of Samples, Setting of the Microscope and Counting/Sizing Procedures (ECB/TM/21(97))....................................................................87 Annex 2: List of Meetings....................................................................................................89 Annex 3: List of Participants in the Meetings......................................................................91 - 3 -
Page 1: This document was prepared from the
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Page 14 and 15: ECB/TM/26 rev.7 Measurements includ
Page 16 and 17: ECB/TM/26 rev.7 It should be noted
Page 18 and 19: 1.4.3.4.3 BODY WEIGHT ECB/TM/26 rev
Page 20 and 21: ECB/TM/26 rev.7 1.4.4.2.2 1.4.4.2.2
Page 22 and 23: 2.3.2 Particles ECB/TM/26 rev.7 Num
Page 24 and 25: 3. REPORTING ECB/TM/26 rev.7 3.1 TE
Page 27 and 28: ECB/TM/27 rev.7 BXX. Biopersistence
Page 29 and 30: 1.4.2.3 Dose Level ECB/TM/27 rev.7
Page 31 and 32: 1.4.3 Procedure ECB/TM/27 rev.7 1.4
Page 33 and 34: ECB/TM/27 rev.7 1.4.3.4.3 BODY WEIG
Page 35 and 36: ECB/TM/27 rev.7 The length and diam
Page 37 and 38: ECB/TM/27 rev.7 2.4.4 Summary Table
Page 39: ECB/TM/27 rev.7 2. Neter, J., Wasse
Page 43 and 44: ECB/TM/18(97) rev.1 B.XX. Carcinoge
Page 45 and 46: For each fibre evaluated, a single
Page 47 and 48: ECB/TM/18(97) rev.1 • At least on
Page 49 and 50: 1.4.4.1.3 FIBRE SIZE DISTRIBUTION E
Page 51 and 52: ECB/TM/18(97) rev.1 2.4 HISTOPATHOL
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II.4 Chronic Inhalation Toxicity of
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ECB/TM/17(97) rev. 2 The fibre unde
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ECB/TM/17(97) rev. 2 1.4.2.8 Labora
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ECB/TM/17(97) rev. 2 musculature, p
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1.4.4.2.1 GRAVIMETRIC (mg/m 3 ) ECB
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ECB/TM/17(97) rev. 2 Mean number of
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ECB/TM/17(97) rev. 2 (4) Bernstein,
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II.5 Sub-chronic Inhalation Toxicit
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ECB/TM/16(97) rev. 1 The fibre unde
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1.4.2.8 Laboratory Validation Fibre
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ECB/TM/16(97) rev. 1 • The remain
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ECB/TM/16(97) rev. 1 Sufficient mon
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2.2 FIBRE CHEMISTRY ECB/TM/16(97) r
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ECB/TM/16(97) rev. 1 · A descripti
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- 85 - Annexes
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ECB/TM/21(97) C) The selected aliqu
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Annex 3 LIST OF PARTICIPANTS IN THE
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