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Nucleation and seeding in protein crystallization - Hampton Research

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Conclusions <strong>and</strong> questions<br />

• In prote<strong>in</strong> <strong>crystallization</strong> the devil is <strong>in</strong> the details<br />

• <strong>Nucleation</strong> is the s<strong>in</strong>gle most important event <strong>in</strong> <strong>crystallization</strong><br />

• Seed<strong>in</strong>g is the most powerful tool for optimization.<br />

• Automated matrix <strong>seed<strong>in</strong>g</strong> is a major breakthrough <strong>in</strong><br />

<strong>in</strong>creas<strong>in</strong>g the number of hits <strong>and</strong> f<strong>in</strong>d<strong>in</strong>g new conditions to<br />

optimize

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