IonWorks Quattro Assay - Molecular Devices

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Summary of Nav Assays on IonWorks n Quattro current expression rate can reach >95%, with peak currents >150 pA n Channel kinetics and pharmacology are consistent with manual patch n Platform provides EP data, use-dependence information, but in quantities similar to other platebased assays
Acknowledgements Neuroscience Howard Zhang Zhuangwei Lou Ed Kaftan Tony Lee John Dunlop Additional Thanks to: Qiang Lu (Novartis) Millipore (U.K.) Ion Channel group
Page 1 and 2: IonWorks Assays for Nav Channels Bi
Page 3 and 4: Sodium Channel Complexes n n α1 (>
Page 5 and 6: Nav1.7 Loss of Function Causes Inse
Page 7 and 8: FLIPR-384: ΔVm Can Identify Blocke
Page 9 and 10: Blocker Characterization with IonWo
Page 11 and 12: Correlation Between Assays IonWorks
Page 13 and 14: Nav1.5 Block by Propafenone: 80 60
Page 15 and 16: Need for IonWorks Quattro Assay n G
Page 17 and 18: I-V curves of Nav1.7 and Nav1.5 on
Page 19 and 20: Screening Nav1.7 State-Dependent Bl
Page 21: Nav1.8 currents on IonWorks IonWork

IonWorks Quattro Assay - Molecular Devices

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