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IonWorks Quattro Assay - Molecular Devices

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FLIPR-384: ΔVm Can Identify Blockers<br />

Na +<br />

12 known<br />

blockers<br />

A<br />

B<br />

C<br />

Na +<br />

-- channel<br />

-50mV<br />

opener<br />

Baseline<br />

fluorescence<br />

+ +<br />

+10mV<br />

Increased<br />

fluorescence<br />

Concentration (µM)<br />

0<br />

D<br />

E<br />

0.14<br />

F<br />

G<br />

0.41<br />

H<br />

I<br />

1.23<br />

J<br />

K<br />

3.70<br />

L<br />

M<br />

11.11<br />

N<br />

O<br />

33.33<br />

P<br />

100.00<br />

Range = ( -2000, 60000 )

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