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24<br />
The <strong>Royal</strong> <strong>Marsden</strong><br />
Antiemetics [3]<br />
5HT3 antagonists<br />
– Indications<br />
– Chemotherapy<br />
– Radiotherapy<br />
– Bowel distension<br />
– Renal failure<br />
– Examples<br />
– Granisetron<br />
– Ondansetron<br />
– Side effect of<br />
constipation<br />
Steroids<br />
– Mode of action<br />
– Reduce permeability of<br />
BBB<br />
– Deplete GABA in<br />
antiemetic neurones<br />
– Anti-inflammatory<br />
– Indications<br />
– Raised intracranial<br />
pressure<br />
– Chemotherapy<br />
– Bowel obstruction<br />
– Example<br />
– Dexamethasone
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