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NEW COATING, NO COATING, ABSORABLE COATING From durable to absorbable polymer ,to EPC capture , to bioabsorbable platform Manufacturer Name Drug Stent material Polymer Status Orbus Neich Genous EPC capture Stainless steel Durable CE Mark Orbus Neich Genous EPC capture Cobalt chromium Durable R & D Orbus Neich Fully absorbable combination drug-eluting and EPC capturing R & D Orbus Neich Combo EPC capture + sirolimus or paclitaxel Biotronik AMS2 New design and new alloy Biotronik Dreams AMS2 with drug containing matrix Stainless steel Durable R & D Biotronik AMS Absorbable metal (Mg) trial Abbott BVS Everolimus Biodegradable trial Abbott BVS 1.1 Everolimus Biodegradable Trial MIVT Smart Midastaurin or sirolimus or zoledronic acid Stainless steel Hap R & D Sahajanand Isoflavone Cobalt chromium Bioabsorbable R & D
# 1 The # New “high durable tech “ of polymer the new from generation Medtronic of polymer • C10 Polymer Based primarily on hydrophobic butyl methacrylate to provide adequate hydrophobicity for zotarolimus CH 2 C CH 2 CH CH 3 a C O O O C10 C O b C 4 H 9 CH 3 • C19 polymer Manufactured from a mixture of hydrophobic hexyl methacrylate and hydrophilic vinyl pyrrolidinone and vinyl acetate monomers to provide enhanced biocompatibility CH 2 C19 CH 3 C CH 2 CH CH 2 CH x y z C O N O O O C O C 6 H 13 CH 3 • Polyvinyl pyrrolidinone (PVP) Hydrophilic polymer increases initial drug burst and enhances biocompatibility PVP CH 2 CH N a O The BioLinx Polymer System Caution: ENDEAVOR RESOLUTE is an investigational device with an investigational drug, not approved for sale or commercial use.
Page 1 and 2: DES: NEW GENERATION OF STENTS and N
Page 3 and 4: 1 st endpoint: Death, MI 2 nd endpo
Page 5 and 6: 1 st endpoint: Death, MI 2 nd endpo
Page 7 and 8: Survey of the next generation of dr
Page 9: NEW COATING, NO COATING, ABSORABLE
Page 13 and 14: This new coating decreases the usua
Page 15 and 16: Enhances the Expression of eNOS mRN
Page 17 and 18: # Porous and micro-porous Porous St
Page 19 and 20: # Porous and micro-porous Nanocarbo
Page 23 and 24: #2 BIOABSORBABLE METAL STENT in Mag
Page 25 and 26: #2 BIOABSORBABLE METAL STENT WITH D
Page 27 and 28: Late Loss 100 80 60 40 20 EES ** :
Page 29 and 30: ACC 2007 Clinical Results Hierarchi
Page 31 and 32: The LIMUS Family of Drugs In-Stent
Page 33 and 34: The LIMUS Family of Drugs - more of
Page 35 and 36: The LIMUS Family of Drugs - more of
Page 37 and 38: NEW DRUGS-BiolimusA9 incorporated w
Page 41 and 42: NEW BIOLOGICAL TARGET NEW DRUGS-TAC
Page 43 and 44: # 4 NEW BIOLOGICAL TARGET- NEW DRUG
Page 45 and 46: CARBOSTENT SRT: The Platform Stent
Page 49 and 50: # ABSORBABLE COATING in Heparinized
Page 51 and 52: #5 DUAL ELUTION HEPARIN AND SIROLIM
Page 53 and 54: # 5 NEW BIOLOGICAL TARGET- NEW DRUG
Page 55 and 56: #5 DUAL ELUTION PACLITAXEL AND PIME
Page 59 and 60: #6 ENDOTHELIAL PROGENITOR CELL CAPT
Page 61 and 62:
late loss QCA (mm) ENDOTHELIAL PROG
Page 63 and 64:
#7 ENDOTHELIAL PROGENITOR CELL CAPT
Page 65 and 66:
The ultimate dream is to produce a
Page 67 and 68:
ENDOTHELIAL PROGENITOR CELL CAPTURE
Page 69 and 70:
#7 ENDOTHELIAL PROGENITOR CELL CAPT
Page 71 and 72:
Today, we can non-invasively diagno
Page 73 and 74:
BIOABSORBABLE DES Today, we can non
Page 75 and 76:
ENDOTHELIAL PROGENITOR CELL CAPTURE
Page 77 and 78:
NEW BIOLOGICAL TARGET NEW DRUGS-Bio
Page 79 and 80:
#2 DUAL ELUTION ZOTAROLIMUS AND DEX
Page 81:
#2 BIOABSORBABLE DES Bioabsorbable
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