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Survey of the next generation of drug-eluting stents: meaningful advances or more of the same 1 New coating (absorbable coating, no coating) Problems with the polymer •Inflammatory response •Increased thrombogenicity •Non-homogenous drug distribution •Flaking, peeling, webbing, bonding
NEW COATING, NO COATING, ABSORABLE COATING From durable to absorbable polymer ,to EPC capture , to bioabsorbable platform Manufacturer Name Drug Stent material Polymer Status Cordis Cypher Sirolimus Stainless steel Durable CE Mark Boston Scientific Taxus Paclitaxel Stainless steel Durable CE Mark Medtronic Endeavor Zotarolimus Cobalt chromium Durable CE Mark Medtronic Resolute Zotarolimus Cobalt chromium Durable CE Filed Abbott ZoMaxx Zotarolimus Tantalum/stainless steel Durable Not Filed Abbott Xience V Everolimus Cobalt chromium Durable CE Mark Braun Coroflex Paclitaxel Cobalt chromium Durable CE Mark Biosensors BioMatrix Biolimus-A9 Stainless steel Bioabsorbable CE Filed Conor CoStar Paclitaxel Cobalt chromium Bioabsorbable CE Mark Sahajanand Supralimus Sirolimus Stainless steel Bioabsorbable CE Mark Sahajanand Infinnium Paclitaxel Stainless steel Bioabsorbable CE Mark Terumo Nobori Biolimus-A9 Stainless steel Bioabsorbable trial Kaneka Mahoroba Tacrolimus Cobalt chromium Biodegradable FIM Biotronick Progenic Pimecrolimus Cobalt chromium Bioabsorbable FIM Sorin Janus Tacrolimus Stainless steel None CE Mark Sorin Carbostent Tacrolimus Cobalt chromium Excipients FIM
Page 1 and 2: DES: NEW GENERATION OF STENTS and N
Page 3 and 4: 1 st endpoint: Death, MI 2 nd endpo
Page 5 and 6: 1 st endpoint: Death, MI 2 nd endpo
Page 7: Survey of the next generation of dr
Page 11 and 12: # 1 The # New “high durable tech
Page 13 and 14: This new coating decreases the usua
Page 15 and 16: Enhances the Expression of eNOS mRN
Page 17 and 18: # Porous and micro-porous Porous St
Page 19 and 20: # Porous and micro-porous Nanocarbo
Page 21 and 22: Survey of the next generation of dr
Page 23 and 24: #2 BIOABSORBABLE METAL STENT in Mag
Page 25 and 26: #2 BIOABSORBABLE METAL STENT WITH D
Page 27 and 28: Late Loss 100 80 60 40 20 EES ** :
Page 29 and 30: ACC 2007 Clinical Results Hierarchi
Page 31 and 32: The LIMUS Family of Drugs In-Stent
Page 33 and 34: The LIMUS Family of Drugs - more of
Page 35 and 36: The LIMUS Family of Drugs - more of
Page 37 and 38: NEW DRUGS-BiolimusA9 incorporated w
Page 41 and 42: NEW BIOLOGICAL TARGET NEW DRUGS-TAC
Page 43 and 44: # 4 NEW BIOLOGICAL TARGET- NEW DRUG
Page 45 and 46: CARBOSTENT SRT: The Platform Stent
Page 49 and 50: # ABSORBABLE COATING in Heparinized
Page 51 and 52: #5 DUAL ELUTION HEPARIN AND SIROLIM
Page 53 and 54: # 5 NEW BIOLOGICAL TARGET- NEW DRUG
Page 55 and 56: #5 DUAL ELUTION PACLITAXEL AND PIME
Page 59 and 60:
#6 ENDOTHELIAL PROGENITOR CELL CAPT
Page 61 and 62:
late loss QCA (mm) ENDOTHELIAL PROG
Page 63 and 64:
Page 65 and 66:
The ultimate dream is to produce a
Page 67 and 68:
ENDOTHELIAL PROGENITOR CELL CAPTURE
Page 69 and 70:
Page 71 and 72:
Today, we can non-invasively diagno
Page 73 and 74:
BIOABSORBABLE DES Today, we can non
Page 75 and 76:
ENDOTHELIAL PROGENITOR CELL CAPTURE
Page 77 and 78:
NEW BIOLOGICAL TARGET NEW DRUGS-Bio
Page 79 and 80:
#2 DUAL ELUTION ZOTAROLIMUS AND DEX
Page 81:
#2 BIOABSORBABLE DES Bioabsorbable
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