Roles of Peripheral Blood CD34+ Cell Count and Midpoint ...

North American Journal of Medicine and Science April 2013 Vol 6 No.2 67
Table 3. Effect of Processed TBV on Number of Collection Sessions for OT ≥ 10x10 6 CD34+ cells/kg.
PB
CD34
Number of
TBV
processed
Per
Session*
PB CD34 based Evidence
Number of
Collection
Days to reach
OT
Evidence
MPY
Number of
TBV
processed Per
Session*
MPY based Evidence
Number of
Collection
Days to
reach OT
Evidence
≥108 3 1
19 out of 20 (19/20)
26 out of 28 (26/28)
≥ 5.5 3 1
patients reached OT
patients
81 - 108 4 1 8 out of 8 patients (8/8) 4.1 - 5.5 4 1 5 / 6 patients
81 - 108 3 1 - 2
4 /6 patients reached
2/ 4 reached
4.1 - 5.5 3 1 - 2
OT within 1 day
OT within 1 day.
61 - 80 4 1 - 2
4 /6 patients reached
1 / 3 reached OT within a
3.1 - 4.0 4 1 - 2
OT within 1 day.
day.
61 - 80 3 1- 2
3/4 sessions reached
2/4 reached OT within
3.1 - 4.0 3 2 - 3 >5x10 6 / kg a day; none
1 day.
reached OT in 1 day.
41 - 60 3 - 4 2 -3
21- 40 4 3 – 4
21- 40 3 3-4, mostly 4
10 - 20 4
3 or more,
(mostly 4)
10 - 20 3 4 or more
5/8 sessions with 4BV
and 6 /11 with 3TBV
reached >5x10 6 /kg a
day. Others did not.
5/7: >4.0 x10 6 /kg;
1/14: >4.0 x10 6 /kg;
2/5: >3.5 x10 6 /kg;
1/14: >3.0 x10 6 /kg,
2.1 - 3.0 3-4 2 – 3
9/14 with 4TBV/ session
and 5/6 with 3TBV
reached
>5 x10 6 /kg.
1.1 - 2.0 4 3 - 4 3/9 >3.5 x10 6 /kg.
1.1 - 2.0 3 3-4, mostly 4
10/21: >2.5 x10 6 /kg,
among them, 4/21:>3.5
x10 6 /kg
0.5 - 1.0 4 no data no data
0.5 - 1.0 3 4 or more
6.0 3 1
4.1 - 6.0 4 1
3.1 - 4.0 4 1 - 2
2.1 - 3.0 4 2 - 3
1.1 - 2.0 4 3 -4
0.5 -1.0 4 4 or more
OT: Optimal Collection CD34 Target
PBCD34 = Pre-collection peripheral blood CD34 (cells/uL)
MPY = Midpoint collection yield CD34 (x10 6 CD34+ cells/kg)
TBV = Total blood volume