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Inserm ALAIN LACAMPAGNE

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Molecular basis of ECC<br />

Ext<br />

T Tubule<br />

Int<br />

I II III IV<br />

+<br />

1 2 3 4 5 6<br />

+<br />

+<br />

1 2 3 4 5 6<br />

+<br />

+<br />

1 2 3 4 5<br />

+<br />

+<br />

6 1 2 3 4 5<br />

+<br />

6<br />

NH 2<br />

COOH<br />

“Voltage sensor”<br />

Cytoplasm<br />

Ryanodine<br />

Receptor<br />

Loop II-III<br />

Foot<br />

COOH<br />

Membrane du RS<br />

1 2 3 4 Channel

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