Gleason grading system
Gleason grading system
Gleason grading system
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PCa has changed dramatically since the late<br />
1960s (type of patients)<br />
• In 1966 there was no screening for<br />
PCa other than by DRE, as serum<br />
PSA had not yet been discovered<br />
• In <strong>Gleason</strong>’s studies, the vast majority<br />
of men had advanced disease with<br />
either local extension out of the<br />
prostate on DRE or distant metastases
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