Dr Larry Distiller BSc MB BCh FCP(SA) FRCP FACE Specialist ...

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• What are the incretins and gliptins? • Why should we use them? • When should they be used? • Should we be using them?
• What are the incretins and gliptins?
Page 1 and 2: Dr Larry Distiller BSc MB BCh FCP(S
Page 3: And many more in development Bianch
Page 7 and 8: L-cell (ileum) ProGIP Proglucagon G
Page 9 and 10: • Slower gastric emptying - Direc
Page 11 and 12: Nauck MA, Baller B, Meier JJ. Gastr
Page 13 and 14: GLP-1 (but not GIP) increases both
Page 15 and 16: The Problem Native GLP-1 and GIP ar
Page 17 and 18: • Synthetic version of the saliva
Page 19 and 20: • Vildagliptin (Galvus® ,Novarti
Page 21 and 22: GLP-1 Analogues • Supra-physiolog
Page 23 and 24: GLP-1 Analogues • Supra-physiolog
Page 25 and 26: • Why should we use them?
Page 28 and 29: Change from baseline to 30 weeks Hb
Page 30 and 31: Significant *vs. comparator; # Chan
Page 32 and 33: • Waist circumference was reduced
Page 34 and 35: Buse et al. Lancet 2009;374:39-47 (
Page 36 and 37: Buse et al. Lancet 2009;374:39-47 (
Page 38 and 39: GLP-1 receptors have been localized
Page 40 and 41: • Promote Weight loss • Lower T
Page 42: • No effect of Exenatide 10 µg o
Page 47 and 48: Vilsboll T et al. BMJ 2012;344:d777
Page 49 and 50: Exenatide Liraglutide Administratio
Page 51 and 52: ‡ Change in A1C, % ‡ Change in
Page 53 and 54: Sitagliptin administration at a sin
Page 55 and 56:
• Why should we use them? • Whe
Page 57 and 58:
• While the effects on glucagon,
Page 59 and 60:
Makes therapeutic sense: Basal insu
Page 61 and 62:
• DPP-4 is found on endothelial a
Page 63 and 64:
• The debate rages! Case reports
Page 65 and 66:
• German data base identified 11
Page 67 and 68:
Elashoff M et al Gastroenterology 2
Page 69 and 70:
“ History has taught us that enth
Page 71 and 72:
Don’t trust me, I’m a doctor…
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Dr Larry Distiller BSc MB BCh FCP(SA) FRCP FACE Specialist ...

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