Dr Larry Distiller BSc MB BCh FCP(SA) FRCP FACE Specialist ...

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Vilsboll T et al. BMJ 2012;344:d7771doi: Published Jan 2012
Exenatide Liraglutide Administration s.c. Twice daily s.c. Once daily Mean Reduction in HbA 1c ~o.8-1.1 % ~1.1-1.5 % Mean reduction in FPG ~0.6 mmol/l ~1.7 mmol/l Mean reduction in body weight 2.87 kg 3.24 kg Persistence of nausea (after 26 weeks) 10 % 5 % Liraglutide appears the better option on all fronts, but this may change with once-weekly exenatide which seems better than daily liraglutide Adapted from: Buse et al. Lancet 2009;374:39–47 (LEAD-6)
Page 1 and 2: Dr Larry Distiller BSc MB BCh FCP(S
Page 3 and 4: And many more in development Bianch
Page 5 and 6: • What are the incretins and glip
Page 7 and 8: L-cell (ileum) ProGIP Proglucagon G
Page 9 and 10: • Slower gastric emptying - Direc
Page 11 and 12: Nauck MA, Baller B, Meier JJ. Gastr
Page 13 and 14: GLP-1 (but not GIP) increases both
Page 15 and 16: The Problem Native GLP-1 and GIP ar
Page 17 and 18: • Synthetic version of the saliva
Page 19 and 20: • Vildagliptin (Galvus® ,Novarti
Page 21 and 22: GLP-1 Analogues • Supra-physiolog
Page 23 and 24: GLP-1 Analogues • Supra-physiolog
Page 25 and 26: • Why should we use them?
Page 28 and 29: Change from baseline to 30 weeks Hb
Page 30 and 31: Significant *vs. comparator; # Chan
Page 32 and 33: • Waist circumference was reduced
Page 34 and 35: Buse et al. Lancet 2009;374:39-47 (
Page 36 and 37: Buse et al. Lancet 2009;374:39-47 (
Page 38 and 39: GLP-1 receptors have been localized
Page 40 and 41: • Promote Weight loss • Lower T
Page 42: • No effect of Exenatide 10 µg o
Page 47: Vilsboll T et al. BMJ 2012;344:d777
Page 51 and 52: ‡ Change in A1C, % ‡ Change in
Page 53 and 54: Sitagliptin administration at a sin
Page 55 and 56: • Why should we use them? • Whe
Page 57 and 58: • While the effects on glucagon,
Page 59 and 60: Makes therapeutic sense: Basal insu
Page 61 and 62: • DPP-4 is found on endothelial a
Page 63 and 64: • The debate rages! Case reports
Page 65 and 66: • German data base identified 11
Page 67 and 68: Elashoff M et al Gastroenterology 2
Page 69 and 70: “ History has taught us that enth
Page 71 and 72: Don’t trust me, I’m a doctor…

Dr Larry Distiller BSc MB BCh FCP(SA) FRCP FACE Specialist ...

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