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CURRICULUM VITAE M. Chesler
Mitchell Chesler MD, PhD
Dept. of Neurosurgery and Dept. of Physiology & Neuroscience
NYU School of Medicine., 550 First Ave., New York, N.Y. 10016
Education
1976 BS (Biology) SUNY Buffalo
1985 PhD (Physiology & Biophysics) NYU (mentor Charles Nicholson)
1986 MD NYU
Postdoctoral Training:
Clinical and Research Fellowships:
1986-1987 (Research) Dept. of Neurology (R. Kraig)
Cornell U. Medical College
1987-1988 (Pathology) Brigham and Women’s Hospital
Harvard Medical School
Academic Appointments
1988-1992 Assistant Professor NYU Departments of Neurosurgery and
Physiology & Biophysics
1992-1996 Associate Professor NYU Departments of Neurosurgery and
Physiology & Neuroscience
1997- Professor NYU Departments of Neurosurgery and
Physiology & Neuroscience
2009- Vice Chair for Research Dept. of Neurosurgery, NYU School of Med.
2010 Co-Director NYU Medical Scientist Training Program
Awards and Honors
1976 Summa Cum Laude B.S. Biology, SUNY Buffalo
1979-1986 Medical Scientist Training Program Fellow
1991 Award for Excellence in Science, U. of Helsinki
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Administrative Responsibilities
CURRICULUM VITAE M. Chesler
1998-2009 Director, Neurosurgery Research Laboratories
2003-2009 Chair of Neurosurgery Tenure and Promotion Committee
1994-present
Medical Scientist Program Faculty Operating Committee
1995-1998 IACUC
1998-present
Bridging and R01 Incentive Program Committee
2000-2009 NYU Sch. Med. Tenure & Promotions Procedures Committee
2009-present
Vice Chair for Research, Dept. of Neurosurgery
2010-present
Co-Director Medical Scientist Training Program
Current Teaching Responsibilities
Lecturer/Conference leader in Medical Student Neuroscience
Lecturer/Conference leader in Graduate Student Neuroscience
Lecturer, Graduate Course on Neural Disorders
Peer Review Service
Current National and Regional Grant Review
2008 - 2012 NIH: Sitting Member NTRC Study Section, CSR, NIH
Past National and Regional Grant Review:
1993-2008 NIH/NSF Ad Hoc Study Section Service:
Neurol. Study Sections: 06/3, 06/94, 10/04, 11/94, 06/00,
Respiratory & Applied Physiology Panel - 06/94
NIH Site Visit Review, Woods Hole Biol. Lab – 08/06
NINDS Program Project Panels: 08/96, 02/99, 04/04, 11/04, 05/05
NICHD Site Visit Panel, Yale University – 07/94, 06/00
Neurodegeneration and Glia study section 05/05, 06/06
Neural Biophysics study section 10/07, 05/08
2002-2005 Howard Hughes Medical Inst. Med. Student Fellowship Review
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CURRICULUM VITAE M. Chesler
1989-present
Other Periodic Ad Hoc Grant Review:
National Science Foundation, Paralyzed Veterans of America,
Veterans Administration, Wellcome Trust,
Med. Res. Council of Canada, Med. Res. Council UK,
Swiss Science Foundation
Graduate Students
Ad Hoc Journal Review
10-20 manuscripts per year.
Recent service for: NatureNeurosci., Nature, J. Physiol., J. Neurophysiol.,
J. Neuroscience, Neuroscience, Glia, Stroke.
Doctoral Students Degree Current Position
Joseph Chen MD-PhD 1989 – 1993 Neurosurgeon, UCSD
Irina Gritchtchenko PhD 1992 – 1996 Asst. Prof. Physiology, U. Colorado
Jay Gottfried MD-PhD 1992 –1996 Asst. Prof. Neurology, N. Western U.
Sabrina Smith MD-PhD 1994 – 1998 Asst. Prof. Neurology U. Penn.
Chi-Kun Tong PhD 1996 – 2000 Res. Asst. Prof. Neurosci. Columbia U.
Sachin Makani PhD 2004 – 2009 Post Doc Lab of Pablo Castillo, AEMC.
Huei-Ying Chen PhD 2009 -
Fellows Time Period Current Position
Dr. A.Z. Hassan 1990 – 1994 Plastic Surgeon, Athens Ga.
Dr. T. Moriya 1992 – 1993 Neurosurgeon, Fukishima, Japan
Dr. W. Huang 1994 –1995 Physician, China
Dr. I. Grichtchenko 1995-1996 Assistant Professor, U. Colorado
Dr. B. Amos 1996 – 1999 Patent Law Associate
Dr. G. Menna 1998 – 1999 Asst. Prof. Anesthesiology, Va. Comm. U.
Dr. A. Bondarenko 1999 – 2002 Res. Associate, Bogomoletz Inst.
Dr. N. Svichar 2000 – 2005 Res. Asst. Prof. NYU Sch. of Med.
Dr. J. Guo 2002 – 2003 Neurosurgeon, Shanghai, China
Dr. N. Fedirko 2004 – 2007 Professor, Lviv State U., Ukraine
Undergraduate Summer Students: Lori Fingerhut, Tufts (2010); Greg Peters, Holy Cross (2011)
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CURRICULUM VITAE M. Chesler
Thesis Committees
NYU Student Period Supervisor
David Krizaj 1992-1994 Dr. Paul Witkovsky
Russel Sanchez 1994-1996 Dr. Christopher Leonard
Adam Boxer 1994-1996 Dr. Edward Ziff
Tom McCormack 1997-1999 Dr. Bernardo Rudy
Dimitrios Davalos 2003-2005 Dr. Wen Bao Gan
Yimi Amarilo 2006-2008 Dr. Bernardo Rudy
William Chen 2001-2003 Dr. Margaret Rice
Davalos, Dimitri 2004-2005 Dr. Wenbiao Gan
Brian Malester 2006-2008 Dr. William Coetzee
Li Bao 2006-2008 Dr. Margaret Rice
Zsuzsanna Pearson 2006-present Dr. Margaret Rice
David Tukey 2006-2009 Dr. Edward Ziff
Amanda Mierzwa 2007-2009 Dr. Jack Rosenbluth
Brian Clark 2008-2010 Dr. Bernardo Rudy
Jhon Sutachan-Rubio 2009-2010 Dr. Moses Chao
Jon Maffie 2010-2011 Dr. Bernardo Rudy
Frank Gooden 2011- Dr. Wenbiao Gan
Extramural Thesis Committees (external examiner)
Student Defense Date Supervisor
Mark Bevensee 1996 Dr. Walter Boron, Yale U.
Joanna Mattis 2007 Dr. C. Schweining, Cambridge U.
Eva Ruusuvuori 2008 Dr. Kai Kaila, U. of Helsinki
Adam Rossano 2011 Dr. Greg Macleod, UT San Antonio
Invited Speaking Engagements
1986 Symposium on Ion Selective Microelectrodes in
Excitable Tissues, University of Toronto
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CURRICULUM VITAE M. Chesler
1989 Symposium on Ion Homeostasis in the Nervous System
University of Helsinki
1991 Neurobiology Seminar Series, Albany Medical College
International Neurotrauma Symposium, Fukushima, Japan
Visiting Professor, University of Helsinki
Neurobiology Seminar Series, Center for Neural Science,
NYU, Washington Square Campus
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CURRICULUM VITAE M. Chesler
1992 Winter Conference on Brain Research Workshop on
“Regulation of Neuronal Excitability by pH”
IBC Conference, Advances in Understanding
and Treatment of Nerve Injury, Philadelphia
Neurobiology Seminar Series, Cornell U. Med. College
1993 Neurobiology Seminar Series, Albert Einstein Coll. Med.
IUPS Meeting, Glasgow. Symposium on pH Regulation
1994 Cornell U. Med. College, Seminar Series, Dept. Neurosurg. 3/94
U. of Minnesota, Seminar Series, Dept. of Physiol., 10/94
U. of Alabama, Seminar Series Neurobiology Res. Ctr., 11/94
1995 Emory University Dept. of Physiology Seminar Series 4/95
1996 American Physiological Society Conference
"The Physiology of pH Regulation", Snowmass, Co. 7/96
1997 Symposium of the Physiological Society, Cambridge University,
Regulation of intracellular calcium and intracellular pH.
1999 Venice Consensus Conference on Epilepsy, Venice 6/99
2000 Winter Conference on Brain Research, Breckinridge, Co. 1/00
2003 Dartmouth Symposium on Glia and Respiratory Control 8/03
Burke Rehabilitation Inst., Cornell U., Whilte Plains NY 11/04
Winter Conference on Brain Research, Breckinridge, Co 1/05
Workshop on Brain pH Regulation and SIDS, Dartmouth, 08/05
Conference on CO2, pH and Brain Function, Helsinki, 09/06
7th Intl. Conf on the Carbonic Anhydrases, St. Augustine 10/06
2007 Emory University Dept. Physiology Seminar Series 04/07
2008 Nathan Kline Institute, 03/08
Symposium on Carbonic Anhydrases, Cologne Germany 03/08
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CURRICULUM VITAE M. Chesler
Symposium on pH Regulation, Phys. Soc. Cambridge U., 07/08
Seminar Speaker, Neuroscience Ctr., U. of Helsinki 11/08
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CURRICULUM VITAE M. Chesler
2010 Seminar Speaker, Dept. of Physiology, Columbia Coll. P&S
German Research Foundation Symposium: The Significance of
Neuroglia for the Formation, Functionand Plasticity of Synapses.
University of Kaiserslautern Aug. 26-29.
Seminar Speaker U. Texas San Antonio, Dept. of Physiology Dec. 6
2011 Seminar Speaker, Dartmouth U., Dept. Physiology June 2011
Seminar Speaker, Dartmouth U., Dept. Pathology June 2011
Seminar Speaker Case Western Reserve U., Dept. Physiology Oct 2011
2012 Experimental Biology Meeting, April 21-25, San Diego) Invited speaker
for symposium "Bicarbonate Transporters in the Nervous System”
Bibliography
Peer-Reviewed Research Articles
1 Chesler M and Fourtner,C (1981). Mechanical properties of a slow muscle in the cockroach.
J. Neurobiol. 12(4):391-402.
2 Chesler M and Nicholson C (1985). Regulation of intracellular pH in vertebrate central
neurons. Brain Res. 325:313-316.
3 Chesler M and Nicholson, C (1985). Organization of the filum terminale of the frog. J.
Comp. Neurol.; 239:431-444.
4 Chesler M (1986). The regulation of intracellular pH in reticulospinal neurones of the
lamprey, Petromyzon marinus. J. Physiol. (Lond.). 381:241-261.
5 Chesler M (1987). pH regulation in the vertebrate central nervous system: microelectrode
studies in the brain stem of the lamprey. Can. J. Physiol. Pharmacol. 65(5):986-993.
6 Chesler M and Kraig RP (1987). Intracellular pH of astrocytes increases rapidly with cortical
stimulation. Am. J. Physiol. 253:R666-670.
7 Chesler M and Chan CY (1988). Stimulus-induced extracellular pH transients in the in vitro
turtle cerebellum. Neuroscience. 27(3):941-948.
8 Walton K and Chesler M (1988). Activity-related extracellular potassium transients in
the neonatal rat spinal cord: an in vitro study. Neuroscience. 25(3):983-996.
9 Chesler M and Kraig RP (1989). Intracellular pH transients of mammalian astrocytes.
J. Neurosci. 9:(6):2011-2019.
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CURRICULUM VITAE M. Chesler
10 Kraig RP and Chesler M (1990). Astrocytic acidosis in hyperglycemic & complete
ischemia. J. Cerebral Blood Flow & Metab. 10(1):104-115.
11 Chen JC and Chesler M (1990). A bicarbonate-dependent increase in extracellular pH
mediated by GABA-A receptors in turtle cerebellum. Neurosci. Lett. 116:130-135.
12 Chen JCT and Chesler M (1991). Extracellular alkalinization evoked by GABA and its
relationship to activity-dependent pH shifts in turtle cerebellum. J. Physiol. 442:431-446.
13 Chesler M and Rice ME (1991). Extracellular alkaline-acid pH shifts evoked by iontophoresis
of glutamate and aspartate in turtle cerebellum. Neuroscience. 41(1):257-268.
14 Chesler M, Sakatani K and Hassan AZ (1991). Elevation and clearance of extracellular K +
following contusion of the rat spinal cord. Brain Res. 556:71-77.
15 Sakatani K, Chesler M and Hassan AZ (1991). GABA-A receptors modulate axonal
conduction in dorsal columns of neonatal rat spinal cord. Brain Res. 542:273-279.
16 Sakatani K, Hassan AZ and Chesler M (1991). GABA-sensitivity of dorsal column axons: an in
vitro comparison between adult and neonatal rat spinal cords. Develop. Brain Res. 61:139-142.
17 Chen JCT and Chesler M (1992). Modulation of extracellular pH by glutamate and GABA in
rat hippocampal slices. J. Neurophysiol. 67(1):29-36.
18 Chen JCT and Chesler M (1992). Extracellular alkaline shifts in rat hippocampal slice are
mediated by NMDA and non-NMDA receptors. J. Neurophysiol. 68(1):342-344.
19 Chen JCT and Chesler M (1992). pH transients evoked by excitatory synaptic transmission are
increased by inhibition of extracellular carbonic anhydrase. Proc. Natl. Acad. Sci. U.S.A.
89:7786-7790.
20 Chesler M. and Chen JCT (1992). Transmitter-dependent modulation of brain pH.
Canadian Journal of Physiology and Pharmacology 1992; 70:S286-S292.
21 Sakatani K, Chesler M, Hassan AZ, Lee M and Young W (1993). Nonsynaptic modulation of
dorsal column conduction by endogenous GABA in neonatal rat spinal cord. Brain Research.
622:43-50.
22 Chesler M, Young W, Hassan AZ, Sakatani K and Moriya T (1994). Elevation and clearance of
extracellular K + following graded contusion of the rat spinal cord. Exptl. Neurol. 125:93-98.
23 Sakatani K, Hassan AZ and Chesler M (1994). Effects of GABA on axonal conduction and
extracellular potassium activity in the neonatal rat optic nerve. Exptl. Neurol. 127(2):291-297.
24 Chesler M, Chen JCT and Kraig RP (1994). Determination of extracellular bicarbonate and
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CURRICULUM VITAE M. Chesler
carbon dioxide concentrations in brain slices using carbonate and pH-selective microelectrodes.
J. Neuroscience Methods. 53(2):129-136.
25 Moriya T, Hassan AZ, Young W and Chesler M (1994). Dynamics of extracellular calcium
activity following contusion of the rat spinal cord. J. Neurotrauma. 11(3):255-263.
26 Grichtchenko I and Chesler M (1994). Depolarization-induced acid secretion in gliotic
hippocampal slices. Neuroscience.. 62(4):1057-1070.
27 Grichtchenko I and Chesler M (1994). Depolarization-induced alkalinization of astrocytes in
gliotic hippocampal slices. Neuroscience. 62(4):1071-1078.
28 Gottfried JA and Chesler M (1994). Endogenous H + modulation of NMDA receptor mediated
EPSCs revealed by carbonic anhydrase inhibition in rat hippocampus. J. Physiol. 478:373-378.
29 Smith SE, Gottfried JA, Chen JCT and Chesler M (1994). Calcium dependence of glutamate
receptor-evoked alkaline shifts in hippocampus. NeuroReport. 5:2441-2445.
30 Huang W, Smith SE and Chesler M (1995). Addition of carbonic anhydrase augments
extracellular pH buffering in rat cerebral cortex. J. Neurophysiol. 74(4):1806-1809.
31 Gottfried JA and Chesler M (1995). Benzolamide inhibits low-threshold calcium currents in
hippocampal pyramidal neurons. J. Neurophysiol. 74(6):2774-2777.
32 Gottfried JA and Chesler M (1996). Temporal resolution of activity-dependent pH shifts in rat
hippocampal slices. J. Neurophysiol. 76(4):2804-2807.
33 Grichtchenko I and Chesler M (1996). Calcium and barium-dependent extracellular alkaline
shifts evoked by electrical activity in rat hippocampal slices. Neuroscience. 75(4):1117-1126.
34 Amos BJ and Chesler M (1998). Characterization of an intracellular alkaline shift in rat
astrocytes triggered by metabotropic glutamate receptors. J. Neurophysiol. 79:695-703.
35 Tong C-K and Chesler M (1999). Activity-evoked extracellular pH shifts in slices of rat dorsal
lateral geniculate nucleus. Brain Research. 815(2):373-381.
36 Tong C-K, and Chesler M (1999). Endogenous pH shifts facilitate spreading depression by
effect on NMDA receptors. J. Neurophysiol. 81:1988-1991.
37 Smith SE and Chesler (1999). The effect of divalent cations on AMPA-evoked
extracellular alkaline shifts in rat hippocampal slices. J. Neurophysiol. 82(4):1902-1908.
38 Menna G, Tong C-K and Chesler M (2000). Extracellular pH changes and accompanying cation
shifts during ouabain-induced spreading depression. J. Neurophysiol. 83(3):1338-1345.
39 Tong C-K, Cammer W and Chesler M (2000). Activity-dependent pH shifts in hippocampal
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CURRICULUM VITAE M. Chesler
slices from normal and carbonic anhydrase II-deficient mice. Glia. 31 (2): 125-130.
40 Tong C-K and Chesler M (2000). Modulation of spreading depression by changes in
extracellular pH. J. Neurophysiol. 84(5):2449-2457.
41 Tong C-K, Brion LP, Suarez C and Chesler M (2000). Interstitial carbonic anhydrase activity in
brain is attributable to membrane-bound CA type IV. J. Neurosci. 20(22):8247-8253
42 Bondarenko A and Chesler M (2001). Rapid astrocyte death induced by transient hypoxia,
acidosis and extracellular ion shifts. Glia. 34:134-142.
43 Bondarenko A and Chesler M (2001). Calcium-dependence of rapid astrocyte death induced
by transient hypoxia, acidosis and extracellular ion shifts. Glia. 34:143-149.
44 Macgregor DG, Chesler M and Rice ME (2001). HEPES prevents edema in rat brain slices.
Neurosci. Letters. 303:141-144.
45 Bhat MA, Rios JC, Lu Y, Garcia-Fresco GP, Ching W, St Martin M, Li J, Einheber S, Chesler M,
Rosenbluth J, Salzer JL, Bellen HJ. (2001). Axon-glia interactions and the domain organization
of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron. 30(2):369-383.
46 Svichar N and Chesler M (2003). Surface carbonic anhydrase activity on astrocytes and neurons
facilitates lactate transport. Glia. 41:415-419.
47 Bondarenko A, Svichar N, and Chesler M (2004). The role of Na + -H + and Na + -Ca 2+ exchange
in hypoxia-related acute astrocyte death. Glia. 49(1):143-152.
48 Shah GN, Ulmasov B, Waheed A, Becker T, Makani S, Svichar N, Chesler M, Sly WS (2005).
Carbonic anhydrase IV and XIV knockout mice: Roles of the respective carbonic anhydrases in
buffering the extracellular space in brain. PNAS 102(46):16771-16776.
49 Svichar N, Esquenazi S, Waheed A Sly WS and Chesler M (2006). Functional demonstration of
surface carbonic anhydrase IV activity on rat astrocytes. Glia 53: 241-247, 2006.
50 Tong CK, Chen K and Chesler M (2006). Kinetics of activity-evoked pH transients and
extracellular buffering in rat hippocampal slices. J. Neurophysiol. 95: 3686-3697.
51 Fedirko, N, Svichar N and Chesler M (2006). Fabrication and use of high speed, concentric H +
and Ca 2+ -selective microelectrodes suitable for in vitro extracellular recording. J. Neurophysiol.
96: 919-924
52. Fedirko N, Avshalumov M, Rice ME and Chesler M (2007). Regulation of post synaptic Ca2+
influx in hippocampal CA1 pyramidal neurons via extracellular carbonic anhydrase.
J. Neurosci. 27(5):1167-1175.
53. Makani S, Chesler M (2007). Endogenous alkaline transients boost post synaptic NMDA
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CURRICULUM VITAE M. Chesler
receptor responses in hippocampal CA1 pyramidal neurons. J. Neurosci. 27(28):.7438-46.
54. Svichar N, Waheed A, Sly WS, Hennings JC, Hübner CA & Chesler M (2009). Carbonic
anhydrases CA4 and CA14 both enhance AE3-mediated Cl - -HCO3 - exchange in hippocampal
neurons. J. Neurosci 29(10): 3252-3258.
55. Makani S, Chesler M (2010). Rapid Rise of Extracellular pH evoked by neural activity is
generated by the plasma membrane calcium ATPase. J. Neurophysiol. 103(2):667-76
56. Makani S, Chesler M (2010). Barium plateau potentials of CA1 pyramidal neurons elicit all-ornone
extracellular alkaline shifts via the plasma membrane calcium ATPase.
J. Neurophysiol. 104(3): 1438-44.
57. Svichar N, Esquenazi S, Chen H and Chesler M (2011). Preemptive Regulation of Intracellular
pH in Hippocampal Neurons by a Dual Mechanism of Depolarization Induced Alkalinization.
J. Neurosci. 31(19):6997-7004.
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CURRICULUM VITAE M. Chesler
Review Articles
58. Chesler, M. (1990). Regulation and modulation of pH in the nervous system.
Progress in Neurobiology . 34:401-427.
59. Chesler, M. and Kaila, K. (1992). Activity-dependent modulation of extracellular pH in the
central nervous system. Trends In Neurosciences. 15(10):396-402.
60. Chesler, M. (2003). Regulation and modulation of pH in the brain. Physiological Reviews. 83(4):
1183-1221
61. Chesler M. (2005). Failure and function of intracellular pH regulation in acute hypoxic-ischemic
injury of astrocytes. Glia. 50:398-406.
Proceedings/Commentary
62. Chesler, M. and Walton, K. (1987). Evoked and spontaneous [K + ] transients are large in
neonatal rat lumbar spinal cord: an in vitro study. Journal of Physiology 1987; 390:46P.
63. Traynelis S. and Chesler M. (2001). Proton release as a modulator of presynaptic function.
Neuron. 32:960-962.
64. Chesler, M. and Traynelis S. (2010). Acid sense and sensibility in the amygdala. Cell Science
Reviews 6(3):31-40.
Book Chapters
65. Chesler, M. and Kraig, R.P. Intracellular pH of astrocytes during spreading depression. In:
Norenberg, M., Hertz, L. and Schousbe, A. eds. Biochemical Pathology of Astrocytes. New York:
Liss Press, 1988:377-378.
66. Kraig, R.P. and Chesler, M. Dynamics of volatile buffers in brain cells during spreading
depression. In: Somjen, G. ed. Cerebral Hypoxia and Stroke: Reversible and Irreversible Effects and
their Prevention. New York: Plenum, 1988:279-289.
67. Kraig, R.P. and Chesler, M. . Glial acid-base homeostasis in brain ischemia.
In: Norenberg, M., Hertz, L. and Schousbe, A. eds. Biochemical Pathology of Astrocytes.
New York: Liss Press, 1988:365-376.
68. Chesler, M. Principles and Practical Aspects of pH Buffering In: Kaila, K.
and Ransom, B.R. eds. pH and Brain Function. New York: John Wiley & Sons.
1998, pp. 11-20.
69. Kaila, K. and Chesler, M. Activity-Induced pH Transients. In: Kaila, K.
& Ransom, B.R. eds. pH and Brain Function. New York: John Wiley & Sons.
1998, pp. 309-338.
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CURRICULUM VITAE M. Chesler
70. Deitmer J and Chesler M.(2009) Neuron-Glia pH Regulation. Encyclopedia of Neuroscience 6:739-
747.
Abstracts
1. Chesler, M. and Fourtner, C, R. (1979) The mechanical properties of a slow muscle in an
insect. Am. Zool. 19:933.
2. Chesler, M. and Nicholson, C.R. (1982) Electrophysiological and morphological
characterization of glia in the filum terminale of the frog. Soc. Neurosci. Abst. 8:237.
3. Chesler, M. and Nicholson, C.R. (1983) Tyrosine hydroxylase and serotonin distribution in
the frog filum terminale. Soc. Neurosci. Abst. 9:1065.
4. Nicholson, C., Chesler, M., Thompson, P. and Do Carmo, R. (1983) Radial glia of mature
turtle cerebellum: Morphology and physiology. Soc. Neurosci. Abst. 9:338.
5. Chesler, M. and Nicholson, C. (1984) Regulation of pH in lamprey central neurons. Soc.
Neurosci. Abst. 10:116.
6. Chesler, M., Chan, C.Y. and Nicholson, C. (1986) Stimulus-evoked alkaline shifts in the invitro
turtle cerebellum. Soc. Neurosci. Abst. 12:696.
7. Chesler, M. and Walton, K. (1987) Evoked and spontaneous [K + ] transients are large in
neonatal rat lumbar spinal cord: an in vitro study. Journal of Physiology 390:46P.
8. Chesler, M. and Kraig, R.P. (1987) Direct recording of intracellular pH from glial cells in rat
brain in vivo. Journal of Cerebral Blood Flow and Metabolism 7:S114.
9. Kraig, R.P. and Chesler, M. (1987) Glial acid-base behavior in brain ischemia. Journal of Cerebral
Blood Flow and Metabolism 7:S128.
10. Chesler, M. and Kraig, R.P. (1987) Intracellular pH of cortical astrocytes rises rapidly with
cortical stimulation. Soc. Neurosci. Abst. 13:126.
11. Chesler, M. and Rice, M.E. (1988). Alkaline extracellular pH transients evoked by aspartate
iontophoresis in cerebellum. Soc. Neurosci. Abst. 14: 791.
12. Chesler, M. and Rice, M.E. (1989). Pharmacologic studies of alkaline extracellular pH
transients in the in vitro turtle cerebellum. Acta Physiologica Scand. 136(Suppl. 582): 61.
13. Chesler, M. and Rice, M.E. (1989). Extracellular pH and Ca shifts evoked by glutamate and
aspartate iontophoresis in turtle cerebellum. Soc. Neurosci. Abst. 15: 948.
14 . Chen, J.C.T., Chesler, M. and Rice, M.E. (1990). Effects of GABA on extracellular pH in
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turtle cerebellum. Soc. Neurosci. Abst. 16: 78.
CURRICULUM VITAE M. Chesler
15. Chesler, M., Sakatani, K., Hassan, Z. and Young, W. (1990). Rapid clearance of [K + ] o
following spinal cord contusion in rat Soc. Neurosci. Abst. 16: 1338.
16. Sakatani, K., Chesler, M., Hassan, Z. and Young, W. (1990). GABA-A receptors on dorsal
column axons in neonatal rat spinal cord. Soc. Neurosci. Abst. 16: 695.
17. Chesler, M. and Hassan, Z. (1991). Extracellular pH and K + gradients in focal ischemia of rat
cortex. Soc. Neurosci. Abst. 17:1265.
18. Chen, J.C.T. and Chesler, M. (1991). Alkaline extracellular pH shifts evoked by glutamate and
GABA in rat hippocampal slice. Soc. Neurosci. Abst. 17:580.
19. Lee, M., Sakatani, K., Hassan, A.Z., Chesler, M. and Young, W. (1991). Effects of
endogenous GABA on axonal conduction in the neonatal rat dorsal column.
Soc. Neurosci. Abstr. 17:1005.
20. Chen, J.C.T. and Chesler, M. (1992). NMDA and non-NMDA receptors mediate
extracellular alkalinizations in the rat hippocampal slice. Soc. Neurosci. Abstr. 18:967.
21. Chesler, M. and Chen, J.C.T. (1992). Role of extracellular carbonic anhydrase in CNS.
Soc. Neurosci. Abstr. 18: 63.
22. Hassan, A.Z., Sakatani, K., and Chesler, M. (1992). Effects of GABA on axonal
conduction and extracellular potassium activity in the neonatal rat optic nerve.
Soc. Neurosci. Abstr. 18:1423.
23. Gottfried, J.A. and Chesler, M. (1993). Extracellular carbonic anhydrase in turtle
cerebellum. Soc. Neurosci. Abstr. 19:267.
24. Chesler, M. and Chen, J.C.T. (1993). Evoked shifts in extracellular pH, bicarbonate and
CO2 in rat hippocampal slices. Soc. Neurosci. Abstr. 19:1522.
25. Grichtchenko, I. and Chesler, M. (1993). Depolarization evoked alkalinization and
extracellular acid secretion by astrocytes of gliotic hippocampal slices. Soc. Neurosci. Abstr.
19:687.
26. Hassan, A.Z., Moriya, T., Zhang, W., Young, W. and Chesler, M. (1993). Dynamics of
blood flow and ionic shifts during local compression ischemia of rat cortex. Soc. Neurosci.
Abstr. 19:1883.
27. Gottfried, J. A. and Chesler, M. (1994). NMDA receptor-mediated EPSCs modulated by
endogenous pH transients in rat hippocampus. Soc. Neurosci. Abstr. 20:1509.
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CURRICULUM VITAE M. Chesler
28. Grichtchenko, I. and Chesler, M. (1994). Depolarization-induced acid secretion of glial
cells : dynamics of extracellular bicarbonate and CO 2 . Soc. Neurosci. Abstr. 20:694.
29. Gottfried, J.A. and Chesler, M. (1995). Optical detection of activity-dependent
extracellular alkaline shifts. Soc. Neurosci. Abstr. 21: 597.
30. Smith, S.E. and Chesler, M. (1995). Calcium-independent extracellular alkaline shifts
evoked by glutamate. Soc. Neurosci. Abstr. 21: 1860.
31. Chesler, M., Huang, W. & Smith, S.E. (1995). Augmentation of extracellular H + buffering by
exogenous carbonic anhydrase in vitro and in vivo. Soc. Neurosci. Abstr. 21: 1082.
32. Amos, B.J., Mathie, A., Richards, C.D. & Chesler, M. (1996). Astrocyte intracellular pH is
increased by activation of metabotropic glutamate receptors. Soc. Neurosci. Abstr. 22: 808.
33. Smith SE, Gritchenko II & Chesler, M. (1996). Activity-dependent extracellular alkaline shifts
in rat hippocampus are supported by Ba 2+ . Soc. Nsci. Abstr. 22:792.
34. Smith, S.E., Amos, B.J. and Chesler, M. (1997). Dynamics of activity-evoked alkaline shifts and
intracellular Ca and Ba transients in hippocampus. Soc. Neurosci. Abstr. 23:136
35. Tong, C.K. and Chesler, M. (1997). Activity-related alkaline pH shifts in rat lateral geniculate
nucleus. Soc. Neurosci. Abstr. 23:652
36. Amos, B.J. and Chesler, M. (1998). Properties of an intracellular alkalinization of rat astrocytes
triggered by metabotropic glutamate receptors. J. Physiol. 506P:12S
37. Tong, C.K. and Chesler, M. (1998). Spreading depression modulated by intrinsic alkaline shift
in rat hippocampal slices. Soc. Neurosci. Abstr. 24:981.
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