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Functional MRI allows researchers Cognitive Therapy May Diminish Pain Using functional MRI tech- to study brain activation-induced niques, Dr. Karen Davis and PhD student David Seminowicz have found evidence changes in blood to support the idea that, in some people, a busy flow, oxygenation, and volume. brain may divert their attention away from a painful experience. The researchers applied a mildly painful stimulus to 16 tion of others. says Dr. Davis.“Our results healthy volunteers who were In this latter group of show a biological basis busy concentrating on a task, people, it also reduced their for the finding that cogni- and measured how their pain-related brain activity. tive therapies may be brains perceived the stimu- “The fact that there are useful for treating pain in lus.They found that while two different types of some people.” the stimulus made some responders suggests that Pain. 2004 Nov; 112 people lose their focus, it different people deal with (1-2): 48-58. sharpened the concentra- pain in different ways,” Up to 20% of people with depression Parkinson’s Disease Treatment Also Alleviates Depression suspected that DBS might be useful to “retune” this area of the brain. The treat- study shows that DBS can lead to striking and sustained remission of depres- fail to respond to medications or In collaboration with a team of Toronto scientists, Drs. Andres Lozano and Sidney ment was successful: changes observed in four of the six patients treated sion in some patients. It further suggests that DBS may become a standard therapy psychotherapy. Kennedy and Dr. Helen Mayberg (Emory University resembled changes that are seen when patients for treating severely depressed people who are For this group, there is a clear need for School of Medicine) recently showed that deep brain stimulation (DBS)—a proce- respond successfully to the standard treatment. Says Dr. Lozano,“Our resistant to drug therapy.” Neuron. 2005 Mar 3; 45(5): 651-60. new treatment dure usually reserved for treating Parkinson’s disease options. and epilepsy—alleviates severe depression. Based on the team’s previous findings that an area of the brain called Cg25 is important for mood regulation, the research team 30 RESEARCH REPORT 2005
RESEARCH ACTIVITY Analysis of Research Activity at UHN Nearly every paper published in a peer-reviewed journal contains a list of citations: references to earlier papers which helped the authors define and answer their current research question. A paper which is influential in its field will be cited frequently by other authors over the months and years following its publication. Citation analysis is used by institutions around the world as one way of measuring research productivity and success. UHN Research has over the past three years been collecting citation analysis information to determine its usefulness as a method of measuring scientific impact over time. Citation analysis uses databases to search and count all references to a certain paper to determine its impact on a field. We can also do this for all papers published by a scientist or group of scientists over a defined time period. Citation Data for Papers Published by UHN Researchers (2002/04 inclusive) # of Papers Citations Papers in Top (2002/04) to date Journals † Top Papers § OCI 1203 10703 159 (13%) 317 (26%) TGRI 1553 12682 150 (10%) 416 (27%) TWRI 1024 6845 51 (5%) 208 (20%) UHN 3497* 28515 340 (10%) 881 (25%) * Where papers are collaborations between scientists at different UHN research institutes, papers are counted only once in the “UHN” total † ”Top Journals” are those journals with an impact factor>10 (as defined by the Institute for Scientific Information) § “Top Papers” are papers in the top 10% of papers (as defined by the Institute for Scientific Information) UNIVERSITY HEALTH NETWORK 31
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