OMEPRAZOLE
OMEPRAZOLE
OMEPRAZOLE
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ROYAL HOSPITAL FOR WOMEN<br />
CLINICAL POLICIES AND PROCEDURES<br />
NEWBORN USE ONLY<br />
GIVEN ON DOCTORS ORDER ONLY<br />
<strong>OMEPRAZOLE</strong><br />
Approved by Neonatal Clinical Committee<br />
DESCRIPTION Proton-pump inhibitor. Inhibits gastric acid secretion by inhibition of<br />
hydrogen-potassium ATPase, the enzyme responsible for the final step in<br />
the secretion of HCL by the gastric parietal cell.<br />
USE Treatment of reflux oesophagitis or duodenal ulcer refractory to<br />
conventional treatment.<br />
PHARMACOLOGY Onset of action is within one hour of administration and the duration of<br />
action is about 72 hours.<br />
DOSE 1-3mg/kg/day daily or in 2 divided doses. Neonates may need 3mg/kg than<br />
1mg/kg in view of variable absorption. Even higher doses may be needed at<br />
the discretion of gastroenterologist and paediatrician.<br />
PRESENTATION 20mg/capsule<br />
2mg/ml suspension<br />
RHW Pharmacy prepares omeprazole suspension by dispersing 100mg<br />
omeprazole (5 capsules) in 50ml of 8.4%sodium bicarbonate solution.<br />
1ml of Omeprazole suspension contains 2mg Omeprazole<br />
1mmol Sodium<br />
1mmol Bicarbonate<br />
STORAGE Stable for 30 days. Refrigerate. Protect from light. Shake the bottle well<br />
before administration.<br />
ADVERSE EFFECTS Limited data. Hypergastrinemia and mild transaminase elevations with<br />
prolonged usage.<br />
MONITORING<br />
1. Consider checking gastric pH (aim >5.0) if there is no symptomatic<br />
improvement.<br />
2. Measure LFTs if duration of therapy is >8 weeks.<br />
DISCHARGE ADVICE RHW Pharmacy supplies a 50 ml bottle of suspension as well as an<br />
instruction sheet to be given to the community pharmacist, if subsequent<br />
bottles should be required.<br />
(A copy of this instruction sheet can be found on the next page.)<br />
REFERENCE<br />
The Australian Journal of Hospital Pharmacy 1998:28:174-6.<br />
Young TE, Mangum B; Neofax: A Manual of drugs used in neonatal care, ed 14. Raleigh, North Carolina: Acorn Publishing,<br />
USA, 2003, p 168.
ROYAL HOSPITAL FOR WOMEN<br />
CLINICAL POLICIES AND PROCEDURES<br />
<strong>OMEPRAZOLE</strong> cont<br />
NEWBORN USE ONLY<br />
GIVEN ON DOCTORS ORDER ONLY<br />
PREPARATION OF <strong>OMEPRAZOLE</strong> SUSPENSION (2mg/ml)<br />
METHOD<br />
Take 5 capsules of Omeprazole (Probitor 20mg)<br />
Instruction Sheet for Community Pharmacist<br />
Approved by Neonatal Clinical Committee<br />
Carefully open the capsules and empty pellets into a 100ml bottle, containing 50 ml of sodium<br />
bicarbonate 8.4% solution. (Use Injection Sodium Bicarbonate 8.4% 100ml<br />
(Pharmacia Upjohn) or any other brand available).<br />
Shake vigorously from time to time to disperse the pellets. This could take over 60 minutes. (As there<br />
is a certain amount of froth, dispense the suspension in the 100ml bottle)<br />
LABEL<br />
1. Omeprazole 2mg/1ml<br />
2. Directions<br />
3. Shake the bottle<br />
4. Refrigerate<br />
5. Discard after 30 days<br />
Department of Pharmacy<br />
Royal Hospital for Women<br />
Barker Street<br />
Randwick NSW 2031
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