Breakthrough Pain - Dolor Irruptivo.com

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Oral Transmucosal Fentanyl Citrate (OTFC) • First rapid onset formulation • Demonstrated viability of using fentanyl • Median onset of relief = 5 minutes; peak plasma concentration +/- 22 minutes • Clinical trials demonstrate safety and efficacy • Limited comparative data Lichtor et al. Anesthesia and Analgesia.1999; 88:732-738. Streisand et al. Anesthesiology. 1991; 75:223-231.Portenoy et al. Pain.1999; 81:129-134. Payne et al. J Pain Symptom Mange. 2001; 22:575-583.
Study OTFC in Breakthrough Cancer Pain Pain Intensity at 15 Minutes Christie 1998 Coluzzi 2001 Farrar 1998 Portenoy 1999 a Total (95% CI) Weighted Mean Difference (Fixed) 95% CI -4.0 -2.0 0 2.0 4.0 Favors OTFC Favors Control
Page 1 and 2: Breakthrough Pain Russell Portenoy,
Page 3 and 4: Breakthrough Pain: Definitional Pro
Page 5 and 6: Breakthrough Pain: Overall Pain Con
Page 7 and 8: Breakthrough Pain: Impact on Mood M
Page 9 and 10: Frequency (%) Breakthrough Pain: Co
Page 11 and 12: Breakthrough Pain: Definitional Pro
Page 13 and 14: Prevalence of Breakthrough Pain •
Page 15 and 16: Cancer-Related Breakthrough Pain: P
Page 17 and 18: Breakthrough Pain: Treatment Issues
Page 25 and 26: Treatment of BTP using Intranasal K
Page 27 and 28: “Rescue Dose” According to Expe
Page 29 and 30: “Rescue Dose” • Most common a
Page 31 and 32: “Rescue Dose” • Studies of fi
Page 33 and 34: “Rescue Dose” • New rapid ons
Page 35: Rapid-Onset “Rescue Dose” • A
Page 39 and 40: Fentanyl (ng/mL ± SEM) Rapid Onset
Page 41 and 42: Episodes, % RCT of Fentany Pectin N
Page 43 and 44: Rapid Onset Opioids: Concerns • M
Page 45 and 46: Opioid Treatment of Breakthrough Pa

Breakthrough Pain - Dolor Irruptivo.com

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