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Two examples of bio-guided isolation, synthesis and ...

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Semi<strong>synthesis</strong>- Perspectives <strong>and</strong> collaborations<br />

Acetogenins <strong>of</strong>’Annonaceae: collaboration with Pasteur Institute, ICSN (Gif-s-Yvette, France)<br />

fluorescent probe (visualisation)<br />

Proteomic<br />

N 3<br />

OR<br />

O<br />

O<br />

OR<br />

O<br />

O<br />

protection, azide formation<br />

OH<br />

OH<br />

O<br />

O<br />

OH<br />

O<br />

O<br />

squamocine<br />

OH<br />

OH<br />

O<br />

KMnO 4<br />

O<br />

OH<br />

OH<br />

R<br />

radical decarboxylation +<br />

O<br />

R<br />

O<br />

R R<br />

OH OH<br />

OH O O<br />

O O<br />

R<br />

BioCIS (UMR CNRS 8076)<br />

R<br />

O<br />

R

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