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Two examples of bio-guided isolation, synthesis and ...

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Synthesis <strong>of</strong> 2- or 3-substituted quinolines (part 3)<br />

N<br />

Cl<br />

RMgX, Fe(acac) 3<br />

THF, -10 °C-0 °C<br />

N<br />

R<br />

N<br />

76%<br />

N<br />

36%<br />

OH<br />

75% N<br />

N<br />

75%<br />

N<br />

70%<br />

(Seck M. et al Tet. Lett. 2004, 45, 1881-1884)<br />

BioCIS (UMR CNRS 8076)

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