Hibiscus rosa sinensis - Ijpcr.com

All developed gels showed good homogeneity with absence
of lumps. No signs of erythema and edema were found after
48 h of application in albino rabbits. During the stability
studies the appearance was clear and no significant variation
in pH was observed. In vitro drug release study as shown in
Table 4 that the formulations containing tulsi oil releases the
drug faster as compared to formulation F- 1 which does not
contain tulsi oil. It may be concluded from the results that as
the concentration of tulsi oil increases in the formulations the
rate of drug release also increases. Percent drug release data
also shows that there is no any significant difference in the
amount of drug released from formulation containing 5 %
and 7 % of tulsi oil. Therefore, formulation containing 5 % of
tulsi oil was selected as best among all the formulations. It is
clear that tulsi oil can significantly enhance the penetration of
naproxen from gel formulation across the skin.
ACKNOWLEDGEMENTS
The authors are thankful to Nicholas Primal, Mumbai, India
for providing gift sample of Naproxen. The authors are
grateful to College of pharmacy, IPS academy, Indore for
providing facilities to carry out the investigation.
Gupta et al. / Formulation and Evaluation of Naproxen Gel....
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