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Appendix 5 - TCC Algorithm: New Non-muscle Invasive Tumour<br />

First TURBT<br />

Non Muscle invasive<br />

Muscle Invasive<br />

See Muscle invasive<br />

algorithm<br />

G1pTa / G2pTa<br />

G2pT1<br />

G3pTa, G3pT1 or CIS<br />

Local MDT<br />

Single dose <strong>of</strong> intravesical<br />

chemo at resection<br />

Flexi cysto at 3/12 (GA or<br />

Flexi)<br />

Assign risk group at first<br />

cystectomy<br />

Solitary tumour initially<br />

Local MDT<br />

6x weekly intravesical chemo<strong>the</strong>rapy<br />

1 st check cysto under GA at 4/12 <strong>the</strong>n<br />

3/12 flexis <strong>for</strong> 2 years, <strong>the</strong>n 6/12 <strong>for</strong> 2<br />

years, <strong>the</strong>n annual <strong>for</strong> life<br />

Multifocal tumour initially<br />

SMDT<br />

Pathology review by experienced uropathologist<br />

Consider 2 nd look TURBT<br />

BCG<br />

Consider cystectomy<br />

Clear Recurrence Clear Recurrence<br />

Low Risk<br />

Flexi at 1 year <strong>the</strong>n<br />

annually <strong>for</strong> 5 years as<br />

per EAU Guidance.<br />

Then annual urine<br />

cytology analysis by GP<br />

Medium Risk<br />

3/12 flexis <strong>for</strong> 1 year <strong>the</strong>n<br />

6/12 flexis <strong>for</strong> 3 years <strong>the</strong>n<br />

annual flexis <strong>for</strong> life<br />

High Risk<br />

6 doses <strong>of</strong> intravesical<br />

chemo <strong>the</strong>n 3/13 flexi <strong>for</strong> 1<br />

year <strong>the</strong>n 6/12 flexi <strong>for</strong> 2<br />

years <strong>the</strong>n annual flexi <strong>for</strong><br />

life<br />

BCG protocol<br />

Induction course<br />

6 weeks with GA cysto and biopsy 8/52<br />

after maintenance schedule as agreed local<br />

protocol.<br />

Monitoring<br />

3/12 flexi <strong>for</strong> 2 years <strong>the</strong>n 6/12 <strong>for</strong> 3 years<br />

<strong>the</strong>n annually <strong>for</strong> life<br />

Page 37 <strong>of</strong> 44

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