Surgical Management of Ulcerative Colitis - Department of Surgery ...

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www.downstatesurgery.org Pathophysiology • Poorly understood • Intestinal mucosa continually exposed to environmental challenge • chronic dysregulation <strong>of</strong> mucosal immunity • uncontrolled inflammatory response • IL-1B, 6, 8, TNF, prostaglandin (E2), leukotriene B4 exacerbate mucosal inflammation • IL-4, 10 suppress intestinal inflammation Maingot 11 th ed
www.downstatesurgery.org Liu et al, Feb 2011 • Sydney Australia; Neurogastroenterology Motility • Tachykinins, like substance P & neurokinin, hemokinin • Role in motility, secretion, and immune functions • Tachykinin receptor gene expression was 10-fold more abundant in colon mucosa <strong>of</strong> pts w/ UC compared to Control (p
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