Gene mutation
Gene mutation
Gene mutation
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Mechanisms of Spontaneous Mutation<br />
The origin of spontaneous hereditary change has always been a topic<br />
of considerable interest. It is known now that spontaneous <strong>mutation</strong>s<br />
arise from a variety of sources, including errors in DNA replication,<br />
spontaneous lesions, and other more complex mechanisms.<br />
Spontaneous <strong>mutation</strong>s are very rare, making it difficult to determine<br />
the underlying mechanisms. How then do we have insight into the<br />
processes governing spontaneous <strong>mutation</strong>? Even though they are<br />
rare, some selective systems allow numerous spontaneous <strong>mutation</strong>s<br />
to be obtained and then characterized at the molecular level for<br />
example, their DNA sequences can be determined. From the nature of<br />
the sequence changes, inferences can be made about the processes that<br />
have led to the spontaneous <strong>mutation</strong>s.<br />
<strong>Gene</strong>tica per Scienze Naturali<br />
a.a. 08-09 prof S. Presciuttini
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