Gene mutation

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Base mismatches Mismatched bases. (a) Mispairs resulting from rare tautomeric forms of the pyrimidines; (b) mispairs resulting from rare tautomeric forms of the purines. Genetica per Scienze Naturali a.a. 08-09 prof S. Presciuttini
From mispairs to mutations (a) A guanine undergoes a tautomeric shift to its rare enol form (G*) at the time of replication. (b) In its enol form, it pairs with thymine. (c and d) In the next replication, the guanine shifts back to its more stable keto form. The thymine incorporated opposite the enol form of guanine, seen in part b, directs the incorporation of adenine in the subsequent replication. The net result is a GC→AT mutation. . If a guanine undergoes a tautomeric shift from the common keto form to the rare enol form at the time of incorporation (as a nucleoside triphosphate, rather than in the template strand diagrammed here), it will be incorporated opposite thymine in the template strand and cause an AT →GC mutation. Genetica per Scienze Naturali a.a. 08-09 prof S. Presciuttini
Page 1 and 2: MUTATIONS Questo documento è pubbl
Page 3 and 4: Basic terminology about gene mutati
Page 5 and 6: Germinal mutations Somatic mutation
Page 7 and 8: Point mutations: base substitutions
Page 9 and 10: Functional consequences of frameshi
Page 11 and 12: Mutations in non-coding regions No
Page 13: Errors in DNA replication Mispairi

Gene mutation

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