Autonomic Nervous System (ANS)
Autonomic Nervous System (ANS)
Autonomic Nervous System (ANS)
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I- Direct acting adrenergic agonists<br />
1- Epinephrine (Adrenaline) A:<br />
- Natural catecholamine, commonly used in<br />
therapy.<br />
- In therapeutic low doses : β R effect<br />
- At high dose : α R effect<br />
Biotransformation:<br />
C.A metabolized by COMT and MAO, and result in<br />
production of metanephrine & vanillyl-mandelic<br />
acid (VMA) in urine.<br />
Note:<br />
A destroyed by acid of stomach & so not effective<br />
orally & usually given SC or IM injection.<br />
-
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