Click here to download the abstract booklet in pdf format - MT19 - Infn

Phase II of our three phase program to develop a 1 GHz
High Resolution LTS/HTS NMR Magnet, entails the design,
construction and testing of a 700 MHz LTS/HTS NMR
magnet. Here we report on the design and construction of
a 100 MHz HTS Insert magnet, its interface to a 600 MHz
LTS magnet, and testing of the LTS/HTS assembly.
Immersed in 4.2 K LHe at atmospheric pressure, the coils
are connected in parallel with the HTS Insert operating at
97.3 A while the background LTS coil carries 240 A. Details
of the cryogenic and magnetic features of the system are
presented.
THA12PO08
A 500 MHz/200 mm RT Solid Neon Cooled Nb3Sn MRI
Magnet - A Status Report
J. Bascuñán, H. Lee, E. Bobrov, S-Y. Hahn, Y. Iwasa, MIT-
Francis Bitter Magnet Laboratory.
We report here on the status of our program aimed to build
and operate a dry MRI magnet. The system incorporates a
new design/operational concept that we believe it will be
eventually adopted by manufacturers of the next
generation of superconducting magnets. System features
include: a) liquid-free; b) if required by the user, cryocooler
microphonics free over a period of time; c) ability to
maintain a constant operating field over a specified period
of time, even in the event of a power outage or during
cryocooler maintenance. The basis of this new
design/operation concept, among other features, is the
presence of solid cryogen, solid neon for this system, in the
cold body that also contains the magnet to enhance
significantly the cold body’s heat capacity. Details of the
system design – magnetic and cryogenics are presented in
this paper.
THA12PO09
Three-Dimensional Motion Control System of
Ferromagnetic Particle for Magnetically Targeted Drug
Delivery System
F. Mishima, T. Hamajima, S-I. Takeda, Y. Izumi, S.
Nishijima, Department of Nuclear Engineering, Graduate
School of Engineering, Osaka University.
Development of 3-dimensional navigation system of the
ferromagnetic particle in a static and/or flow systems were
performed. In order to advance from the practice of using
externally-applied magnetic fields to target in situ magnetic
particles to a circumscribed body region, a 3-dimensional
navigation system by utilizing external magnetic field was
proposed and the feasibility of the present system was
investigated. A 3-D theoretical model was established and
used in order to evaluate the degree of the
navigation/retention of magnetic particles. Furthermore, an
experimental model system was made and the efficiency of
a prototype system was examined. Comparisons of
experimental and corresponding modeling data were made
to verify the theoretical predictions. The obtained results
suggest that the 3-D model of calculation and the
experimental system for magnetically targeted drug
delivery system can be used as a platform for an effective
magnetic drug-targeting tool with a multitude of medical
applications.
THA12PO10
Development of Magnetic Force-Assisted New Gene
Transfer System using Biopolymer-Coated
Ferromagnetic Nanoparticles
S-I. Takeda, F. Mishima, B. Terazono, Y. Izumi, S.
Nishijima, Department of Nuclear Engineering, Graduate
School of Engineering, Osaka University
Development of a simple method for converting the lipid
envelope of an inactivated virus to a gene transfer vector
was achieved in the medical school of Osaka University.
Hemagglutinating virus of Japan (HVJ; Sendai virus)
envelope (HVJ-E) vector introduced plasmid DNA
efficiently and rapidly into various cell lines, including
cancer cells and several types of primary cell culture.
Efficiency of gene transfer was found to be greatly
enhanced by application of a magnetic field. In the present
study, we developed a new type of magnet for magnetically
enhancing and targeting gene transfection system by using
vectors associated with ferromagnetic particles coated with
positively/negatively charged biopolymers, which can help
to enhance and target gene delivery with higher efficiency.
For the transfection experiment in vitro, the HVJ-E vector
was mixed with ferromagnetic particles coated with
biopolymer and this mixture was added to cultured cells
which were set up under the various types of magnetic
fields. The effect of the strength and gradient of the
magnetic field on the efficiency of the transfection was
discussed. The accuracy of the targeted size was also
examined with a comparison of the calculation of the
magnetic fields.
THA12PO11
Development of a Superconducting Joint for High Field
NMR
T. Fukuzaki, H. Maeda, RIKEN Genomic Sciences Center;
T. Kiyoshi, S. Matsumoto, S. Nimori, NIMS
A high sensitivity and high resolution NMR magnet is
constructed with multiple superconducting magnets. Each
magnet is joined in a series by a superconducting joint
between the NbTi conductor and the Nb3Sn conductor (or
the NbTi conductor), and the magnet is usually operated in
the persistent mode. An NMR magnet with sufficient
magnetic field stability (for example, field decay