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ISOPT Program

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Section: EXTERNAL EYE DISEASES<br />

Chairperson: P.A. Asbell, USA<br />

<strong>ISOPT</strong> <strong>Program</strong><br />

Dry Eye Disease / Biomarkers for Ocular Surface Disease<br />

Proteomics for the Diagnosis of Ocular Surface Disease<br />

R. Beuerman, Singapore<br />

Protein Biomarkers and Tear Film and Dry Eye Disease<br />

F. Grus, Germany<br />

Lymphocytes Detection on the Ocular Surface of Dry Eye Patients<br />

S. Barabino, Italy<br />

Impression Cytology and Dry Eye Disease<br />

P. Asbell, USA<br />

Panel Q&A<br />

All Speakers<br />

Anterior Segment Imaging / Devices<br />

Anterior Segment OCT<br />

J.S. Mehta, Singapore<br />

Imaging and In Vivo Confocal Microscopy for Assesing Inflammatory Ocular Surface<br />

Diseases<br />

C.Baudouin, France<br />

Confocal Microscopy: New Development<br />

R. Beuerman, Singapore<br />

DSAEK ‐ Cornea Insertion Devices<br />

P. Asbell, USA<br />

OCT and Tearfilm<br />

L. Fan, China<br />

Panel Q&A<br />

All Speakers


Meibomian Gland Dysfunction<br />

Tear Film & Ocular Surface Society<br />

Session Moderators: K. Nichols, USA, P. Asbell, USA & D. Sullivan, USA<br />

Introduction<br />

K. Nichols, USA<br />

Definition and Classification of Meibomian Gland Dysfunction (MGD)<br />

K. Nichols, USA<br />

Anatomy, Physiology and Pathophysiology of the Meibomian Gland<br />

D. Sullivan, USA<br />

Tear Film Lipids, and Lipid‐Protein Interactions, in Health and Disease<br />

D. Sullivan, USA<br />

Epidemiology of, and Associated Risk Factors for, MGD<br />

K. Nichols, USA<br />

Evaluation, Diagnosis and Grading of Severity of MGD<br />

M. Rolando, Italy<br />

Management and Therapy of MGD<br />

C. Baudouin, France<br />

Design and Conduct of Clinical Trials<br />

P. Asbell, USA<br />

Cases: Discussion<br />

Post Lasik Dry Eye<br />

Presented by:<br />

P. Asbell, USA<br />

R. Beuerman, Singapore<br />

I. Barequet, Israel<br />

M.K. Kim, S. Korea


Section: INFLAMMATION AND INFECTION<br />

Chairperson: R. Neumann, Israel<br />

Ocular Infectious Uveitis<br />

Ocular Tuberculosis<br />

P. Choopong, Thailand<br />

Ocular Toxoplasmosis<br />

TBA<br />

Emerging Ocular Infections and Their Therapy<br />

TBA<br />

Posterior Uveitis<br />

Management of Posterior Uveitis: Adapting Therapy to Specific Diagnosis<br />

VKH, Behcet's, BSCR, Sarcoidosis, Idiopathic<br />

Panel: E. Letko, USA, M. Kramer, Israel, H. Uy, Philippines, C. Deuter, Germany<br />

Managing Uveitis in Children<br />

Immunosuppressive Agents in Children<br />

The Effect of Steroids in Children<br />

Biologic Agents in Children<br />

Panel: D. Chu, USA, E. Letko, USA, C. Deuter, Germany, M. Kramer, Israel<br />

Ocular Infection<br />

Chairperson: I. Barequet, Israel<br />

The Evaluation of Antibiotics in the Prophylaxis or Treatment of Endophthalmitis<br />

Using Animal Model<br />

T, Suzuki, USA<br />

TBA<br />

C.K. Joo, South Korea<br />

Bacteriologic Profile of the Conjunctiva and Susceptibility to Fluoroquinolones<br />

N. Maeda, Japan<br />

Infection of Ocular Surface (Corneal Ulcers) in Vietnam National Institute of<br />

Ophthalmology<br />

P. Thi Khanh Van, Vietnam<br />

Antibacterial Prophylaxis in Anterior Segment Surgery<br />

I. Barequet, Israel


UVA Light and Riboflavin Application for Infectious Keratitis<br />

E. Letko, USA<br />

TRUST: Tracking Resistance of Ocular Infections<br />

P. Asbell, USA<br />

Section: GLAUCOMA<br />

Chairpersons: J. Jonas, Germany & X. Zhang, China<br />

New Drug Classes on the Horizon for Glaucoma Therapy<br />

Different Modalities of Ocular Drug Delivery for Glaucoma<br />

T. Wong, Singapore<br />

Medical Treatment for Angle Closure Glaucoma<br />

S. Sawaguchi, Japan<br />

Drug and Technique: Wound Modulation in Glaucoma Surgery<br />

K. Nagpal, India<br />

Statins and Glaucoma<br />

D. Leung, Hong Kong<br />

New Devices in Glaucoma Therapies<br />

Anterior Segment OCT in Glaucoma<br />

M. He, China<br />

Applications of Ocular Response Analyzer in Normal Tension Glaucoma<br />

D. Leung, Hong Kong<br />

The Use of the ExPress Implant in Asian Eyes<br />

H.C. Ling, Singapore<br />

Selective Laser Trabeculoplasty in the Treatment of POAG<br />

T. Wang, China<br />

Glaucoma Screening With a Self‐Operated, Inexpensive, Comprehensive Instrument:<br />

Can It Be Done?<br />

A. Walsh, USA<br />

Tube vs. Trabeculectomy Study<br />

TBA<br />

Latest Thinking on Mechanisms in Glaucoma<br />

TRP Channel: A Potential Target for Human Glaucoma<br />

X. Zhang, China<br />

The Activation and Modulation of Astrocyte in Glaucoma<br />

W. Jihong, China


Correlation in Genotype and Phenotype in POAG<br />

J. Ge, China<br />

Population Based Studies and Vascular Risk Factors<br />

A. Harris, USA<br />

Glaucoma: Just Another Optic Neuropathy<br />

TBA<br />

R. Ellis‐Behnke, Hong Kong<br />

Axon Injury and Axon Therapy<br />

L. Levin, USA<br />

Physical Therapy and Neuroprotection for Glaucoma<br />

N. Wang, China<br />

Neuroprotection<br />

Neuroprotective Effects of CNP on Glaucomatous Neuropathy<br />

L. Xuyang, China<br />

Neuroprotective Effects of Agmatine on Various Oxidative Stressed Neurons<br />

S. Hong, S. Korea<br />

Protective Effect of Gross Saponin of Tribulus Terrestris (GSTT) on Retinal Ganglion<br />

Cells and Optic Nerve in Rabbits with Chronic Intraocular Hypertension<br />

L. Huang, China<br />

New Pathways in Neuroprotection<br />

C. Zhang, China<br />

TBA<br />

R. Ellis‐Behnke, Hong Kong<br />

Worldwide Glaucoma Economics<br />

Glaucoma Screening ‐to Increase Potential Value<br />

L. Xu, China<br />

Glaucoma Economics and Prevalence in China<br />

Z. Jialiang, China<br />

EVER Symposium<br />

Session Chair: L. Schmetterer, Austria<br />

Pathogenic Hints for Glaucoma from the Optic Nerve Head<br />

J. Jonas, Germany<br />

Autoimmunity and Glaucoma<br />

F. Grus, Germany


Impact of Long Term Use of Preservatives on the Ocular Surface<br />

C. Baudouin, France<br />

What Can We Expect from Functional OCT for Glaucoma<br />

L. Schmetterer, Austria<br />

Section: RETINA<br />

Chairperson: B.D. Kupperman, USA<br />

Dry AMD<br />

Alprostadil<br />

A. Augustin, Germany<br />

Anti‐C3<br />

C. Francois, USA<br />

Retinoids<br />

D. Saperstein, USA<br />

Complement Inhibition for AMD ‐ Overview<br />

F. Behar, France<br />

ACU‐4429‐Visual Cycle Modulator as Potential Therapy for DRY AMD<br />

N. Boman, USA<br />

AREDS 2<br />

P. Bernstein, USA<br />

Wet AMD<br />

Role of Inflammation in AMD and DR<br />

A. Augustin, Germany<br />

Lucentis versus Avastin for CNV/AMD<br />

A. Loewenstein, Israel<br />

Ozurdex Plus Lucentis for CNV<br />

B. Kuppermann, USA<br />

PDGF Plus Lucentis for CNV<br />

D. Boyer, USA<br />

POT RACE Study<br />

D. Boyer, USA<br />

DENALI/Mt BLANC/EVEREST<br />

TBA<br />

Wet AMD Panel<br />

TBA


Wet AMD Combination Therapy<br />

Triple Therapy<br />

A. Augustin, Germany<br />

Iluvien Plus Lucentis<br />

TBA<br />

Diabetic Retinopathy<br />

Role of Vitreous in DR Progression<br />

A. Gandorfer, USA<br />

Vascular Toxicity or Steroids<br />

F. Behar, France<br />

TA/Steroids for inhibition of progression of DR<br />

M. Ip, USA<br />

Macugen<br />

V. Gonzalez, France<br />

Diabetic Macular Edema<br />

Laser Plus Anti‐VEGF for DME<br />

A. Augustin, Germany<br />

Ozurdex for DME<br />

B. Kuppermann, USA<br />

Iluvien FAME for DME<br />

B. Boyer, USA<br />

Lucentis READ 2<br />

D. Do, USA<br />

VEGF Trap Phase 2<br />

D. Do, USA<br />

Laser Plus Steroids for DME<br />

F. Bandello, Italy<br />

Role of The Lallikrein‐Kinin System in Diabetic Retinopathy<br />

P. Belichard, France<br />

Lucentis RISE & RIDE<br />

TBA<br />

Macugen<br />

V. Gonzalez, USA<br />

ICo‐007, a VEGF "+" Agent for the Potential Treatment of Diabetic Macular Edema<br />

and Diabetic Retinopathy<br />

V. Gonzalez, USA


Treatments for Retinal Vein Occlusion<br />

Lucentis/Ranibizumab for Central Retinal Vein Occlusion: CRUISE<br />

A. Loewenstein, Israel<br />

Lucentis/Ranbizumab for Branch Retinal Vein Occlusion: BRAVO<br />

A. Loewenstein, Israel<br />

Ozurdex for RVO<br />

B. Kuppermann, USA<br />

SCORE CRVO Study ‐ Corticosteroid for Retinal Vein Occlusion<br />

M. Ip, USA<br />

SCORE BRVO<br />

M. Ip, USA<br />

Macugen<br />

V. Gonzalez, USA<br />

Anti‐angiogenetic Agents ‐ Other Diseases<br />

Anti‐VEGF for ROP<br />

K. Drenser, USA<br />

TBA<br />

Retinal Degeneration<br />

rh‐RdCV<br />

P. Belichard, France<br />

Cis Beta Carotene for Congenital Stationary Night Blindness<br />

Y. Rotenstreich, Israel<br />

Vitreous<br />

Microplasmin Treatment of Vitreoretinal Disease: Update on the Phase III MIVI‐<br />

TRUST <strong>Program</strong><br />

A. Gandorfer, Germany<br />

Section: BASIC SCIENCE<br />

Therapies of Retinal Neovascularization<br />

Session Moderators: A. Das, USA & J. Penn, USA<br />

TBA<br />

J. Penn, USA<br />

TBA<br />

D. Sinha, USA


TBA<br />

D. Hinton, USA<br />

TBA<br />

R. Caldwell, USA<br />

Inhibition of Diabetic Retinopathy<br />

Session Moderators: A. Das, USA & R. Kowluru, USA<br />

Diabetic Retinopathy and Mitochondrial Damage<br />

R. Kowluru, USA<br />

TBA<br />

T. Chan‐Ling, Australia<br />

TBA<br />

A. Stitt, Ireland<br />

Targeting the GAPDH Nuclear Translocation Pathway as a Potential New Strategy to<br />

Prevent Hyperglycemia‐Induced Retinal Damage<br />

S. Mohr, USA<br />

TBA<br />

R. Caldwell, USA<br />

Antioxidants<br />

Session Chair: P. Bernstein, USA<br />

Long‐Chain and Very Long‐Chain Polyunsaturated Fatty Acids in Ocular Aging and<br />

Age‐Related Macular Degeneration<br />

P. Bernstein, USA<br />

Macular Pigment Changes in Pseudophakic Eyes Quantified With Resonance Raman<br />

Spectroscopy<br />

A. Obana, Japan<br />

TBD<br />

A. Ohira, Japan<br />

Vascular Targets<br />

Session Chairs: L. Schmetterer, Austria & G. Garhoefer, Austria<br />

Role of Endothelins in Ocular Disease<br />

G. Garhoefer, Austria<br />

Retinal Circulations in Diabetes<br />

T. Nagaoka, Japan<br />

Dynamic Autoregulation<br />

L. Wang, USA


Interaction Between Intraocular Pressure and Blood Flow: Relevance for Glaucoma<br />

L. Schmetterer, Austria<br />

Gene Therapy<br />

Session Chair: C. Paterson, USA<br />

AMD Gene Therapy<br />

S. Wadsworth, USA<br />

Gene Therapy in Glaucoma<br />

CP Pang, Hong Kong<br />

Section: TCM<br />

Chairperson: X. Li, China<br />

Basic Pharmacology of TCM<br />

Session Chair: J. Duan, China<br />

Molecular Mechanism on Neuroprotection in Glaucoma Using Lycium Barbarum<br />

(Wolfberry)<br />

KF. So, Hong Kong<br />

Establishment and Evaluation of the High Throughput Screening System for<br />

Antagonistic Agents of Dry Eye Based on TGF‐β1 and Bcl‐2<br />

KH. Peng, China<br />

The Protection of the Compound Chinese Medicine MingMuWuZi on Rat Model of<br />

Light‐induced Retinal Injury<br />

HJ. Ye, China<br />

Research of Chinese Medicine QiDengMingMu Capsule Therapy Effect on STZ<br />

Induced Diabetic Rat's Blood‐Retinal Barrier and Visual Function Damage<br />

FW. Zhang, China<br />

Research of Chinese Medicine QiDenmingmu Capsule Therapy Effect on<br />

Spontaneous Diabetic Rats Retina Protein Kinase C and Vitreous Vascular Endothelial<br />

Growth Factor<br />

N. Gao, China<br />

Clinical Trials of TCM<br />

Session Chair: J. Duan, China<br />

Effects of TCM Qiming Granule on Diabetic Retinopathy: A Report of Randomized<br />

Control Multicenter Clinical Trials<br />

J. Duan, China<br />

Effect of Runmuling on Tears of the Patients With Dry Eye: A Clinical Study and<br />

Explanation of its Mechanism<br />

YL. Wang, China


Randomized Double‐Blind Placebo‐Controlled Multicenter Clinical Study of the<br />

Protective Effect of Gingko Leaf Extract on Glaucoma with IOP Controlled<br />

XJ. Lu, China<br />

Characteristics of the Corresponding Relationship of Metabolomics Profiling<br />

Between Yang Deficiency Syndrome and Diabetic Retinopathy Stage<br />

XX. Luo, China<br />

Astragalus Membranaceus and its Prescriptions in Treating Diabetic Retinopathy: a<br />

Systematic Review<br />

L. Cheng, China<br />

Section: Drug DEVELOPMENT<br />

IP and the Path to Commercialization<br />

Session Chair: R. Beuerman, Singapore<br />

TBA<br />

M. Tabiin, Singapore<br />

TBA<br />

M. Entzeroth, Singapore<br />

Reading Centers<br />

Session Chair: R. Danis, USA<br />

Non‐Standardization of Technology in Ophthalmology<br />

Y. Huang, USA<br />

Data Quality Issues in Clinical Trials<br />

M. Ip, USA<br />

Requirements and Validation of Biometry in Ophthalmic Devices<br />

M. Eydelman, USA<br />

When Do You Need a Reading Center?<br />

R. Danis, USA<br />

Drug Delivery<br />

Session Chairs: D. Tang‐Liu, USA & R. Gurny, Switzerland<br />

Encapsulated Cell Technology for Retinal Degenerative Diseases<br />

W. Tau, USA<br />

The Role of Ocular Pigmentation in the Intraocular Pressure Response to Brimonidine<br />

in Rabbits<br />

J. Burke, USA<br />

Pharmacokinetics and Pharmacodynamics Considerations in Posterior Segment Drug<br />

Delivery<br />

J.E. Lin, USA


Controlled Transscleral Drug Delivery Formulations to the Eye: Establishing New<br />

Concepts and Paradigms in Ocular Anti‐Inflammatory Therapeutics and Antibacterial<br />

Prophylaxis<br />

J. Cardillo, Brazil<br />

Toxicology<br />

Macular Pigment Changes in Pseudophakic Eyes Quantified with Resonance Raman<br />

Spectroscopy<br />

A. Obana, Japan<br />

TBA

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