SEQUEL Fact Sheet - Ancare

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fact sheet
Ancare Australia Pty Ltd
Building D, 12-24 Talavera Rd
Macquarie Park NSW 2113
Ph (02) 9893 0071
Fax (02) 9893 0099
genesis@ancare.com.au
www.ancare.com.au
A dual combination oral drench for sheep containing 1g/L ABAMECTIN, a
member of the macrocyclic lactone family of chemicals (mectin drenches) and
40g/L LEVAMISOLE (as levamisole hydrochloride), a member of the
imidazothiazoles family of chemicals (clear drenches). It also contains 0.5g/L
SELENIUM (as sodium selenate) and 2.2g/L COBALT (as cobalt disodium
EDTA).
• Broad spectrum
• Short acting combination drench
• Controls BZ, levamisole and ML resistant worms^
• Standard 1mL per 5kg dose rate
COMBINATION POWER
SEQUEL Abamectin/Levamisole Combi Drench contains two short acting
ingredients. Abamectin is more potent than ivermectin and has a short chemical tail.
Levamisole has good efficacy against Haemonchus and Cooperia, the species mectins
find hard to kill. At the recommended dose rate, SEQUEL treats and controls the
following sheep roundworms, sensitive to at least one of the two deworming agents
contained in the product:
Adult and immature gastro-intestinal roundworms
Barbers Pole Worm (Haemonchus contortus)*
Small Brown Stomach Worm (Teladorsagia [Ostertagia] circumcincta)*
Stomach Hair Worm (Trichostrongylus axei)*
Black Scour Worm (Trichostrongylus spp)*
Small Intestinal Worm (Cooperia spp)*
Thin Necked Intestinal Worm (Nematodirus spp)
Hookworm (Bunostomum trigonocephalum)
Intestinal Threadworm (Strongyloides papillosus)
Large Bowel Worm (Oesophagostomum venulosum)
Large Mouthed Bowel Worm (Chabertia ovina)
Nodule Worm (Oesophagostomum columbianum)
Whipworm (Trichuris ovis)
* including inhibited fourth stage larvae
SEQUEL also provides a selenium and cobalt supplement for sheep raised in selenium
and/or cobalt deficient areas
ASSISTS IN THE MANAGEMENT OF CHEMICAL RESISTANCE
Resistance may develop to any drench. However, studies have shown that using
combination drenches, such as SEQUEL, can significantly delay the development of
resistance. SEQUEL is active against sheep roundworms that have single resistance
to the benzimidazole, imidazothiazole (levamisole) or macrocyclic lactone^ families of
chemicals. It is advisable that a drench-resistance test be conducted before any drench
is used.

STANDARD DOSE RATE
The dose rate of 1mL/5kg bodyweight is the same low dose of traditional drenches and application is by
the oral route using any standard drenching equipment. At the given dose rate, SEQUEL delivers 0.2mg
abamectin, 6.8mg levamisole (8mg levamisole hydrochloride), 0.1mg selenium and 0.44mg cobalt per kg
bodyweight.
Bodyweight Dose 5 Litre Treats 15 Litre Treats
DO NOT treat lambs under 15kg.
16 to 20kg 4mL 1250 3750
21 to 25kg 5mL 1000 3000
26 to 30kg 6mL 833 2500
31 to 35kg 7mL 714 2142
36 to 40kg 8mL 625 1875
41 to 45kg 9mL 555 1666
46 to 50kg 10mL 500 1500
51 to 55kg 11mL 454 1363
56 to 60kg 12mL 416 1250
61 to 65kg 13mL 384 1153
66 to 70kg 14mL 357 1071
71 to 75kg 15mL 333 1000
Dose animals heavier than 75 kg at 1 mL per 5 kg
Re-treatment interval: DO NOT re-treat animals for 6 weeks after last treatment.
ANIMAL SAFETY
SEQUEL should not be used when selenium intake from pasture is high or selenium is provided by other
means (such as pasture top dressing, vaccine, pellets or selenium drenches) if blood selenium levels at
treatment are high. Users can determine the sheep’s selenium status by consulting their veterinarian.
Selenium can have toxic effects, particularly in sheep with liver damage that graze in areas where plants
containing pyrrolizidine alkaloids (e.g. heliotrope and Paterson’s curse) are present. Do not add additional
selenium to the drench and do not use at the same time as other selenium treatments (e.g. selenised
vaccines, drenches or pellets, pasture top dressing) without consulting a veterinarian. Do not administer
selenium supplements at intervals less than three weeks or within one year of long-term selenium bullet or
capsule treatment.
Because SEQUEL contains levamisole, exercise care in handling weak, pregnant and young animals to
avoid unnecessary stress. Avoid yarding animals off-feed overnight, and ensure animals have access to
water when yarded prior to drenching. Stress and lack of feed or water may enhance the chance of
levamisole toxicity, even with the recommended dose. Recommended dose should not be exceeded,
except under veterinary supervision.
Do not administer SEQUEL to sheep that are dehydrated or unwell and do not use in lambs under six
weeks of age or less than 15kg bodyweight.
WITHHOLDING PERIODS
MEAT: 14 days
EXPORT SLAUGHTER INTERVAL (ESI): 42 days
MILK: DO NOT USE in sheep which are producing or
may in the future produce milk where the milk or milk
products may be used for human consumption.
PACK SIZES AVAILABLE
5L Backpack
15L Drum
^Claim for control of ML-resistant worms subject to APVMA
approval at time of printing.