Chapter 9 - Lipids and Biological Membranes

SphingolipidsThese phospholipids are based on sphingosine, rather than glycerolHCH 3 (CH 2 ) 12 C C CH CHCH 2 OHHOHNH 2- Ceramide = N - fatty acid derivative- Sphingomyelin = (typically) ceramide + Phosphate + choline or ethanolamine- Cerebroside = ceramide + single sugar- Ganglioside = ceramide + oligosaccharideA sphingomyelin is shown below. Sphingomyelins are important membrane components.HOCH 3 (CH 2 ) 12 C C CH CHCH 2 O P OH OH NH OCH 2 CH 2 N(CH 3 ) 3+COCerebrosides and gangliosides are glycosphingolipids. Both cerebrosides and gangliosides lackphosphate groups; rather, they are both contain mono- (cerebrosides) or complex saccharides(gangliosides) bonded to a ceramide moiety via an O-glycosidic linkage. A ganglioside is shownin Figure 9-9.