2011 - NIH Clinical Center - National Institutes of Health

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2010 BENCH-TO-BEDSIDE AWARDSAIDS CATEGORY: PROJECTS FUNDED BY OFFICE OF AIDS RESEARCHThe Bench-to-Bedside (B2B) Program was launched in 1999, and 176 projects totaling about$40 million have been funded to date. The program expanded in 2006 to include extramuralcollaborators with 68 grants supplemented so far. Over the past five cycles, extramural interestin the program has greatly increased; in the current 2011 application cycle, investigators from114 extramural institutions were listed as collaborators or principal investigators on the143 Letters of Intent.PROJECTNew Bioinformatic Approach toDetermine HIV IncidenceRole of Gut-Associated LymphoidTissue in HIV-1 PersistenceMultiplex Microarray Chip-basedDiagnosis of Respiratory Infectionsin HIVINVESTIGATORS INSTITUTE(S)/INSTITUTIONNCI: F. Maldarelli; M. Kearney; W. Shao; NIAID: R. Dewar; Johns Hopkins University,Bloomberg School of Public Health: J. Margolick; Los Angeles Biomedical Research Instituteat Harbor-UCLA Medical Center; (LA BioMed): E. DaarNCI: F. Maldarelli; M. Kearney; University of Pittsburgh: D. McMahon; National Naval MedicalCenter: A. GanesanCC: J. Kovacs; A. Suffredini; P. Murray; NIAID: S. Holland; J. Cuellar-Rodriguez;NCI: J. Gea-Banacloche; R. Lempicki; Washington Hospital Center: M. SmithBEHAVIORAL & SOCIAL SCIENCES CATEGORY: PROJECT FUNDED BY OFFICE OF BEHAVIORAL & SOCIAL SCIENCES RESEARCHAntibody Identification and IVIGTreatment of PANDASNIMH: S. Swedo; Yale University: J. Leckman; Oklahoma University Health Sciences Center:M. CunninghamWOMEN’S HEALTH: PROJECTS FUNDED BY OFFICE OF RESEARCH ON WOMEN’S HEALTHAdrenal Hyperplasia AmongAdolescent Patients WithPolycystic Ovarian SyndromeNICHD: C. Stratakis; SUNY: S. TenMINORITY HEALTH CATEGORY: PROJECTS CO-FUNDED BY NATIONAL CENTER FOR MINORITY HEALTH & HEALTH DISPARITIES AND INSTITUTES/CENTERSControl of XMRV Replication inPBMCs and Prostate CarcinomasIn vitro Fucosylation to AugmentCord Blood Stem Cell EngraftmentBiochemical Mechanisms of theEtiology of Sickle Cell PainNCI: V. Pathak; A. Rein; W. S. Hu; F. Maldarelli; University of California, Davis: R. deVere White;H.J. KungNHLBI: R. Childs; J. Pantin; CC (Transfusion Medicine): D. StroncekNIDDK: A. Schechter; NINR: R. Dionne; CC (Transfusion Medicine): D. Stroncek; W. SmithBeth Israel Medical Center: R. Portenoy; R. CrucianiGENERAL CATEGORY: PROJECTS CO-FUNDED BY NATIONAL CENTER FOR RESEARCH RESOURCES AND INSTITUTES/CENTERSOptical Guidance for ImprovedProstate Cancer SurgeryImaging CXCR4-ExpressingCancer Using 64CuAMDCC (Radiology and Imaging Sciences): B. Wood; M. Dreher; A. Kapoor; NCI: P. Pinto;W. Linehan; Massachusetts General Hospital: U. MahmoodNIAID: J. Farber; I. Weiss; NIBIB: X. Chen; O. Jacobson; NCI: P. Choyke;Georgetown University: C. IsaacsPHARMACOGENOMICS CATEGORY: PROJECT FUNDED BY FOOD & DRUG ADMINISTRATION (FDA)Mechanism of Response toAnti-TNF Therapy in InflammatoryBowel DiseaseNIAID: M. Yao; W. Strober; I. Fuss; University of MD: R. Cross; M. Flasar24 • ANNUAL REPORT 2011
RARE DISEASES CATEGORY: PROJECTS CO-FUNDED BY OFFICE OF RARE DISEASES RESEARCH AND INSTITUTES/CENTERSPROJECTTargeting Antigen-Antibody Responsesin Systemic Capillary Leak SyndromeSympathetic Innervation & MyocardialInjury in Acute Stress CardiomyopathyPreclinical Testing of Targeted Agentsfor Clinical Development in NF1The DICER1-related PleuropulmonaryBlastoma Cancer PredispositionSyndromeBrain Development in Children withWilliams Syndrome and theLIMK1 GeneThe Role of EGFR inEndolymphatic Sac TumorsINVESTIGATORS INSTITUTE(S)/INSTITUTIONNIAID: K. Druey; T. Myers; S. Porcella; NCI: O. Landgren; NIBIB: A. Gorbach;University of Minnesota: A. Dudek; Mayo College of Medicine: P. GreippCC (Radiology and Imaging Sciences): C. Sibley; D. Bluemke; NINDS: D. Goldstein;NHLBI: D. Rosing; Johns Hopkins: I. Wittstein; F. Bengel; J. Mudd; J. LimaNCI: A. Kim; B. Widemann; E. Dombi; Children’s Hospital Medical Center: N. Ratner; J. WuNCI: C. Kratz; B. Alter; P. Rosenberg; National Children’s Medical Center: A. Hill;Children’s Hospital & Clinics of MN: Y. Messinger; K. SchulzNIMH: K. Berman; J. Kleinman; University of Louisville: C. MervisNCI: P. Dennis; Yale University: A. VortmeyerRARE DISEASES DRUG DEVELOPMENT: PROJECTS CO-FUNDED BY THERAPEUTICS FOR RARE AND NEGLECTED DISEASES PROGRAMAND INSTITUTES/CENTERSA Novel Therapy to Treat Acid Lipase-Deficiency by LCAT InhibitionDevelopment of Combination Therapyfor Niemann-Pick Disease, Type CGene Therapy Clinical Trial for LAD-1Using a Foamy Viral VectorBH3 Mimetics for the Treatment ofAutoimmune LymphoproliferativeSyndromePreventing Aortic Dilation in Womenwith Turner SyndromeImmunogenicity and LeishmaniaVaccine Potential of Sandfly Saliva inHumansNHLBI: A. Remaley; K. Vickers; R. Shamburek; Cincinnati Children’s Hospital MedicalCenter - Research Foundation: G. Grabowski; H. DuNICHD: F. Porter; A. Yergey; S. Bianconi; NHGRI: W. Pavan;Washington University: D. OryNCI: D. Hickstein; University of Washington Medical Center: D. Russell; CincinnatiChildren’s Hospital Medical Center: P. MalikCC (Laboratory Medicine): J. Oliveira Filho; T. Fleisher; NIAID: V. Rao; K. Dowdell;NIDDK: D. AppellaNICHD: C. Bondy; V. Bakalov; J. Zhou; NHLBI: A. Arai; D. Rosing; M. Boehm; V. Sachdev;Johns Hopkins University: J. Van Eyk; Q. FuNIAID: J. Valenzuela; S. Kamhawi; Uniformed Services University of the Health Sciences/Walter Reed Army Medical Center: N. Aronson; George Washington University:M. BottazziPROJECT FUNDED BY THE NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENTThe Role of BDNF in Autism SpectrumDisorder and Cognitive FunctionNICHD: J. Han; C. Pierpaoli; NIMH: K. Martinowich; D. Weinberger; C. Golden Williams;S. Swedo; A. Thurm; NCI: L. Tessarollo; Uniformed Services University of the HealthSciences/Walter Reed Army Medical Center: S. Sharp; GlaxoSmithKlinePharamceuticals: B. LuANNUAL REPORT 2011• 25
Page 1 and 2: PROFILE 2011There’s NoOther Hospi
Page 3: PROFILE 2011There’s NoOther Hospi
Page 6 and 7: OUR VISION As America’s research
Page 8 and 9: Patient Activity and SupportHOME ST
Page 10 and 11: PATIENT ART ON DISPLAYthe “Hope F
Page 12 and 13: EDMOND J. SAFRA FAMILY LODGE MARKS
Page 14 and 15: SURGERY SPACES RENOVATED TO IMPROVE
Page 16 and 17: HOSPITAL RECOGNIZES COMMUNITY OF CA
Page 18 and 19: Advancing Clinical Research PROTOCO
Page 20 and 21: A panel of representativesof differ
Page 22 and 23: Recovery Act funds go to Clinical C
Page 24 and 25: SYMPOSIUM PRESENTS CHALLENGES AND T
Page 28 and 29: NEW UNIT PROVIDES UNIQUE SUPPORT FO
Page 30 and 31: LEARNING ABOUT RESEARCHAND HEALTHY
Page 32 and 33: NURSES PRESENT ON TRIBAL COMMUNITY
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Page 40 and 41: In addition to the symptoms of long
Page 42 and 43: GRADUATE MEDICAL EDUCATION BROADENS
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Page 46 and 47: Clinical Center for assistance in i
Page 48 and 49: TRAINEE FORUM INTRODUCES FUTURE COL
Page 50 and 51: Organizational Improvement/Teamwork
Page 52 and 53: EMERGENCY PREPAREDNESS PARTNERSHIP
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Page 56 and 57: NoteworthyMaryland governor visitsG
Page 58 and 59: In her opening remarks at the kicko
Page 60 and 61: Organization and GovernanceADVISORY
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