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Profile Critical Care Xpress offers a comprehensive 20-test<br />

critical care profile including blood gases, electrolytes,<br />

chemistry, hematology, and co-oximetry. Nova is among the few<br />

critical care companies to offer serum creatinine as part of its<br />

analyzer test profile and is the only critical care company to<br />

provide the eGFR calculation. Version 5 software enables Stat<br />

Profile Critical Care Xpress analyzers to be configured for all of<br />

the currently accepted eGFR equations, including Cockcroft-<br />

Gault, MDRD, and IDMS-Traceable calculations for adults, and<br />

Schwartz and Counahan-Barrett calculations for children.<br />

Contact novabio.com.<br />

ADAPTIVE<br />

Respironics, Inc announced that it has formed an agreement<br />

with The State University of New York (SUNY) and New York<br />

University School of Medicine (NYU) to utilize the I-neb<br />

Adaptive Aerosol Delivery (AAD) System for clinical evaluation<br />

of aerosolized Interferon Gamma for the treatment of Idiopathic<br />

Pulmonary Fibrosis (IPF). The clinical trial will take place over<br />

a two-year time period. The I-neb device uses Respironics’ AAD<br />

technology which is an intelligent inhalation technology that<br />

continually monitors and automatically adapts to an individual<br />

patient’s breathing pattern to deliver a precise medication dose<br />

during the patient’s inhalation phase. The result is precise,<br />

reproducible dosing of medication to each patient, regardless of<br />

his/her breathing pattern. Precise dosing is important in<br />

ensuring that patients receive a safe and therapeutic dose of<br />

medication. The I-neb AAD System is Respironics’ third<br />

generation AAD System and is smaller, quieter and more<br />

portable than earlier product generations. The device weighs<br />

less than eight ounces and can be carried discreetly in a purse,<br />

pocket or briefcase. The I-neb device also provides audible and<br />

visual feedback to the patient informing the patient when the<br />

treatment is complete.<br />

NEWS FEATURES<br />

AARC SYMPOSIUM:<br />

LAS VEGAS, 2007 - HELONTIX<br />

Helium/Oxygen Mixtures<br />

in Children: Bronchiolitis<br />

and Other <strong>Respiratory</strong><br />

Obstruction<br />

Federico Martinón-Torres, MD, PhD<br />

The author is with Hospital Clínico Universitario de Santiago, Spain. The<br />

following was presented at AARC 2007, at the Helontix Symposium.<br />

Despite the apparently conflicting clinical evidence regarding<br />

it’s utility, heliox has gained widespread support and use in<br />

many pediatric emergency departments and intensive care units.<br />

Several potential indications have been suggested for heliox<br />

therapy, with particularly outstanding beneficial effects for<br />

patients with asthma, bronchiolitis, and upper respiratory<br />

obstructions with various etiologies.<br />

Helium is a biologically inert gas of low molecular weight,<br />

which, when blended with oxygen, results in a gas mixture<br />

(heliox) with a markedly lower density than air (specifically,<br />

heliox with 21% oxygen has one third the density of air). Its<br />

application in the setting of obstructive airway disease will<br />

decrease airway resistance to flow, and thus reduce the work of<br />

breathing. Heliox has also been shown to enhance alveolar<br />

ventilation due to its high diffusion coefficient, which may<br />

improve carbon dioxide removal. Heliox has no inherent<br />

therapeutic effect, and thus can be used only as a temporising<br />

agent - it provides time until definitive therapies act or the<br />

subjacent pathologic circumstance spontaneously resolves. The<br />

inert nature of heliox explains the extreme rarity of secondary<br />

effects and the negligible risk of its clinical use. Interestingly,<br />

any beneficial effect of heliox should become evident in a<br />

relatively short period of time, one hour usually being sufficient.<br />

We have extensively evaluated the therapeutic safety and<br />

efficacy of non-invasive administration of heliox, to infants with<br />

acute moderate to severe bronchiolitis: first as an initial elective<br />

treatment administered via a non-rebreathing mask with<br />

reservoir in patient spontaneously breathing; or secondly as a<br />

rescue treatment for patients refractory to the standard<br />

treatment, administered noninvasively in combination with<br />

positive pressure, via a system adapted for the use of nasal<br />

continuous positive pressure with heliox. In our experience, the<br />

elective treatment with heliox administered non-invasively to<br />

infants with acute moderate to severe bronchiolitis, via a nonrebreathing<br />

reservoir mask, improves respiratory conditions in a<br />

simple, innocuous, safe and non-invasive way. This was<br />

demonstrated by the noticeable improvement of the clinical<br />

scores, the decrease of the concomitant tachycardia and<br />

tachypnoea and the reduction in the length of stay (

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