Hot Topics in Pediatric Infectious Diseases - Duke Pediatrics Intranet

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Expanding clone• Article in “Infectious Diseases in Children”Dec 2006 discusses a S. pneumoniaeclone 19A that is highly resistant to mostcommonly used antibiotics• Quote rates of 20% resistance• Only susceptible to Fluoroquinolones andTelithromycin
Serotype 19A clone has increased since theintroduction of vaccineOverall, researchers found that frequency ofserotype 19A among multiple antibioticresistantstrains had risen from around one in100 in 2000, to more than one in five by 2005…Farrell and colleagues speculate this may bedue to the overuse of antibiotics and theintroduction of the PCV7 vaccine….An analysis of resistance showed 100%resistance rates to penicillin, cefuroxime(Zinacef, GlaxoSmithKline), the macrolides(erythromycin, azithromycin, clarithromycin)cotrimoxazole and tetracycline.Farrell said amoxicillin-clavulanate (Augmentin,GlaxoSmithKline) would commonly be given tochildren suspected of having antibiotic resistantpneumococcal infection. However, for this clonein 2000, it was effective just less than half thetime. By 2005, 83.1% of the 19A clone wereresistant to amoxicillin-clavulanate.No strains were resistant to levofloxacin(Levaquin, Ortho-McNeil) and only 0.7% ofstrains were resistant to telithromycin (Ketek,Sanofi-Aventis). However, the FDA indicatesneither of these drugs for pediatric use.Here’s what they don’ttell you…
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Hot Topics in Pediatric Infectious Diseases - Duke Pediatrics Intranet

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