Hot Topics in Pediatric Infectious Diseases - Duke Pediatrics Intranet

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The real truth…• They never give you a denominator to theirpercentages– They sampled macrolide resistant clones (20% of total)and 20% of those were MDR• 20% of 20% is 4% of the total! Worrisome yes, but does notmean we should panic!• The study was funded by Sanofi-Aventis, makersof Ketek (telithromycin)– At the time, the company wanted to continue with pediatric developmenteven though their drug was investigated because of severe liver toxicity(deaths and FHF requiring transplant in 5 patients!)– The FDA, after much embarrassment, withdrew approval inFeb07
The real truth…• Serotype 19A is showing up as a frequentcause of invasive S. pneumo disease• However, overall rates of invasive diseaseare stable nationally and significantlybetter than pre-PCV7• SO, even though the “pie” of invasivepneumococcal disease is “changingflavor”, it is still much smaller than before• 19A may cause a future increase, but itmay not….• Best for you to keep vaccinating and keepusing antibiotics prudently
Page 3: Time for“change you can believe i
Page 6 and 7: New data on FluMist• Study compar
Page 8 and 9: More data on FluMist• Study compa
Page 10 and 11: More data on FluMist• No signific
Page 12 and 13: What to do for now?• Issue right
Page 14 and 15: Current Influenza Activityhttp://ww
Page 16 and 17: An Epidemic that progresses…• 1
Page 18 and 19: CA-MRSA• Community Acquired (or A
Page 20 and 21: CA-MRSA: better science• A recent
Page 22 and 23: CA-MRSA: better scienceKennedy et a
Page 24 and 25: CA-MRSA: better science• What are
Page 26 and 27: Expanding clone• Article in “In
Page 30 and 31: Take 2 aspirin and call me in themo
Page 32 and 33: Febrile Child• ALL of this data i
Page 34 and 35: • From 1997-9What we found…- Th
Page 36 and 37: What we found…• Occult bacterem
Page 38 and 39: Time for a change…• The data sh
Page 40 and 41: Boldly go where no man(one) hasgone
Page 42 and 43: The future in viral diagnosis.• Y
Page 44 and 45: In related news…Renwick et al,JID
Page 46 and 47: Exhaled aerosols• Huynh et al use
Page 48 and 49: Microbiology Folklore:The dangers o
Page 50 and 51: The “Double Dip”• For those o
Page 52 and 53: The “Double Dip”• The study f
Page 54 and 55: 5 second rule• They found that Sa

Hot Topics in Pediatric Infectious Diseases - Duke Pediatrics Intranet

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