PATHways - American College of Veterinary Pathologists

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Volume 3, Issue 1 Page 10 Case Report The case of the mass-Laden Macaque And the answer is……………. Microscopic diagnosis: Chronic endometriosis with adhesions Comments: Endometriosis is the ectopic growth of endometrial tissue, outside the uterus (Fanton et al., 1986). Endometriosis is a common disorder of sexually mature female macaques with a reported incidence of up to 30% in some colonies (Zondervan et al., 2004). Reported clinical signs in macaques with endometriosis are non-specific and include body weight loss, anorexia, constipation, decreased fertility and anemia. The masses in the abdominal and pelvic cavity can occasionally be palpated externally or by digital rectal examination. Grossly, endometriosis is often observed as mottled, tan, cystic masses in the pelvic and abdominal cavity over the surface of uterus, urinary bladder, distal colon and ovaries. Histologically, these masses are composed of ectopic endometrial glands and stroma with hemorrhage. This ectopic endometrial tissue undergoes cyclical changes in response to estrogen and progesterone, however the endometriotic lesions have been reported to have defective hormonal regulation (Sternfeld et al., 1988) Though an exact mechanism for the development of endometriosis is not known, it has been proposed that retrograde menstruation through the fallopian tubes causes the spread of endometrial tissue to the pelvic and peritoneal cavity (metastatic theory). Another hypothesis is that ectopic endometrium arises directly from the mesothelium of pelvis or abdomen (metaplastic theory). Risk factors for endometriosis reportedly include genetic predisposition, hysterectomy, whole body irradiation and exposure to toxins (Cline et al., 2008, Zondervan et al., 2004). Endometriosis is an important clinical condition of women and can cause infertility, pelvic pain and dysmenorrhea among other complications. Non human primates have been used as a model to investigate human endometriosis. References available on page 13.
Volume 3, Issue 1 References for Case Report Cline, J.M., Wood, C.E., Vidal, J.D., Tarara, R.P., Buse, E., Weinbauer, G.F., de Rijk, E. & van Esch, E. (2008). Selected Background Findings and Interpretation of Common Lesions in the Female Reproductive System in Macaques. Toxicol Pathol, 36, 142- 164. Fanton, J.W., Hubbard, G.B. & Wood, D.H. (1986). Endometriosis: clinical and pathologic findings in 70 rhesus monkeys. American journal of veterinary research, 47, 1537-1541. Sternfeld, M.D., West, N.B. & Brenner, R.M. (1988). Immunocytochemistry of the estrogen receptor in spontaneous endometriosis in rhesus macaques. Fertility and sterility, 49, 342-348. Zondervan, K.T., Weeks, D.E., Colman, R., Cardon, L.R., Hadfield, R., Schleffler, J., Trainor, A.G., Coe, C.L., Kemnitz, J.W. & Kennedy, S.H. (2004). Familial aggregation of endometriosis in a large pedigree of rhesus macaques. Human reproduction (Oxford, England), 19, 448-455. American College of Veterinary Pathologists 2810 Crossroads Drive Suite 3800 Madison, Wisconsin 53718 Phone: 608-443-2466 Fax: 608-442-2474 Email: membership@acvp.org * Contributed to this newsletter Society of Toxicologic Pathology 1821 Michael Faraday Drive Suite 300 Reston, VA 20190 Phone: 703-438-7508 Fax: 703-438-3113 Email: stp@toxpath.org Newsletter Committee Members Feel free to contact committee members with questions or for advice ACVP Recruiting Committee Student Chapter Subcommittee Chair: Brett Saladino (brett.saladino@covance.com) Newsletter Group: Krista La Perle (la-perle.1@osu.edu) Stephanie Corn* (stephanie-corn@idexx.com) Amanda Fales-Williams (afales@iastate.edu) Check out the ACVP Student Chapters group on Facebook! http://www.facebook.com/#!/group.php?gid=1238795976443 10 This is a great site for student chapters to: �� Exchange ideas about meeting topics �� Get ideas for fundraising �� Look for housing for externships �� Find roommates for meetings STP Career Outreach Committee Student Interactions Subcommittee Chair: Sarah Tannehill-Gregg (sarah.tannehill-gregg@bms.com) Newsletter Group: Sarah Tannehill-Gregg* (sarah.tannehill-gregg@bms.com) Lyn Wancket (wancket.1@osu.edu) Chris Palgrave (chris_palgrave@ncsu.edu) Alok Sharma (alok.sharma@covance.com) Susan Van Tongeren (susan.vantongeren@boehringeringelheim.com) Page 11
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PATHways - American College of Veterinary Pathologists

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