The Genetic Mysteries of the Corneal Dystrophies The Genetic ...

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Fleck Dystrophy• Subtle grey opacities consist of small, wreath-likeopacities in the stroma• Represent engorged keratocytes• Usually asymptomatic• Cases with photophobia , ocular surface irritation andblepharospasm have been recently reported• Opacities extend to the periphery• Visual acuity good throughout life since stroma betweenflecks remains clear• Maps to chromosome 2 (2q35)14
Pre-Descemets Dystrophy• Fine, deep white posterior stromal opacities• Lie anterior to Descemets membrane• Autosomal dominant• No effect on visual acuityCentral Cloudy Dystrophy of Francois• Central opacity in stroma looks like cracked-iceor crocodile skin; glycosaminoglycan deposition• Visual acuity is usually normal• Appearance similar to crocodile shagreen, anage-related corneal change resulting in posteriorstromal deposition• Difficult to differentiate from crocodile shagreenin the late course of disease, especially ifbilateral15
Page 1 and 2: The GeneticMysteries of theCorneal
Page 3 and 4: Epithelial Basement Membrane Dystro
Page 6 and 7: Autosomal Dominant Recurrent Cornea
Page 8 and 9: Granular Dystrophy• Opacities con
Page 11 and 12: Lattice Dystrophy Type II• Associ
Page 13: Central “Crystalline” Dystrophy
Page 17 and 18: Treatment of Fuch’s Dystrophy•
Page 19 and 20: Posterior Polymorphous Dystrophy•

The Genetic Mysteries of the Corneal Dystrophies The Genetic ...

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